Browse our latest Microbiology and Infectious Disease articles

Page 74 of 167
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Within-host evolutionary dynamics of seasonal and pandemic human influenza A viruses in young children

    Alvin X Han, Zandra C Felix Garza ... Colin A Russell
    The longer duration of seasonal influenza virus infection in young children may provide opportunities for within-host evolution as a result of maintenance of genetic diversity through mutation-selection balance.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Integrated single-cell analysis unveils diverging immune features of COVID-19, influenza, and other community-acquired pneumonia

    Alex R Schuurman, Tom DY Reijnders ... Tom van der Poll
    Different etiologies of community-acquired pneumonia evoke both shared and diverging immunological responses.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Tonic interferon restricts pathogenic IL-17-driven inflammatory disease via balancing the microbiome

    Isabelle J Marié, Lara Brambilla ... David E Levy
    Overlapping action of type I, II, and III interferons maintains microbiome homeostasis, prevents IL-17-driven myeloproliferative disease, and protects against inflammatory bowel disease.
    1. Microbiology and Infectious Disease

    Functional development of a V3/glycan-specific broadly neutralizing antibody isolated from a case of HIV superinfection

    Mackenzie M Shipley, Vidya Mangala Prasad ... Julie M Overbaugh
    A bnAb derived from a case of HIV superinfection has distinct qualities from other HIV-specific bnAbs, including framework residues that contribute to neutralization breadth and a unique viral escape profile.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Malaria: A genetic intervention

    Colin Sutherland, Didier Menard
    A tool that analyzes the genome of parasites found in the blood of malaria patients can help inform policy decisions on how best to tackle the rise in drug-resistant infections.
    Version of Record
    Insight
    1. Cell Biology
    2. Microbiology and Infectious Disease

    CTP and parS coordinate ParB partition complex dynamics and ParA-ATPase activation for ParABS-mediated DNA partitioning

    James A Taylor, Yeonee Seol ... Kiyoshi Mizuuchi
    CTP and centromere-like parS-DNA act synergistically and catalytically to activate ParB, which remains activated after leaving parS to tune ParA–ParB and ParB–ParB interaction dynamics for robust ParABS-mediated F-plasmid DNA segregation.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    A low Smc flux avoids collisions and facilitates chromosome organization in Bacillus subtilis

    Anna Anchimiuk, Virginia S Lioy ... Stephan Gruber
    Bacterial chromosome folding by DNA loop extrusion is here shown to rely on avoidance of SMC collisions by low SMC abundance, clustering of loading sites, efficient translocation, and rare unloading.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Dynamic persistence of UPEC intracellular bacterial communities in a human bladder-chip model of urinary tract infection

    Kunal Sharma, Neeraj Dhar ... John D McKinney
    Live-cell imaging captures the heterogenity of bacterial growth within intracellular bacterial communities and demonstrates that the constituent bacteria are protected from clearance by antibiotics delivered with a physiologically relevant pharmacodynamic profile.
    1. Microbiology and Infectious Disease

    The development of Nanosota-1 as anti-SARS-CoV-2 nanobody drug candidates

    Gang Ye, Joseph Gallant ... Fang Li
    Potent and low-cost Nanosota-1 drug candidates block SARS-CoV-2 infections in vitro and in animal models and act preventively and therapeutically.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Genetic surveillance in the Greater Mekong subregion and South Asia to support malaria control and elimination

    Christopher G Jacob, Nguyen Thuy-Nhien ... Olivo Miotto
    Large-scale genetic surveillance of malaria implemented by National Malaria Control Programmes informs public health decision makers about the spread of strains resistant to antimalarials.