An analysis of 10,395 research publications about COVID-19 that mention at least one human gene reveals that many genes implicated in SARS-CoV-2 infection by genome-wide studies remain unstudied.
Interactions between viral RNA and the integrase enzyme are required for HIV-1 particles to become infectious, a process that can be disrupted through multiple mechanisms.
Doxycycline used at a slightly higher concentration kills Plasmodium falciparum malaria parasites with faster, first-cycle activity through a novel organelle-specific mechanism.
A novel bacterial deubiquitinase with multiple chain types specificity regulates the association of ubiquitinated proteins on the phagosome of Legionella pneumophila.
Tracking fluorescent fusion proteins in competent pneumococcal cells reveals a polar hub for competence regulation, with the alternative sigma factor σX relocalizing DprA to this hub to mediate competence shut-off.
A novel, overlapping, putatively functional gene in SARS-CoV-2, ORF3d, is absent from close relatives of SARS-CoV-2 and may have contributed to the biology, emergence, or spread of the virus.
Tick-derived sequence variation in the fusion glycoprotein of Crimean-Congo hemorrhagic fever virus (CCHFV) drastically impairs infection of mammalian cells, suggesting that certain CCHFV strains undergo purifying selection in mammalian hosts.
Timothy J de Wet, Kristy R Winkler ... Digby F Warner
A high-throughput functional genomics approach combining inducible CRISPR-interference and quantitative imaging yields an atlas of 'phenoprints' to guide gene function assignments, identify metabolic pathway-specific morphotypes, and inform antibiotic mechanism-of-action studies.
