Browse our latest Microbiology and Infectious Disease articles

Page 91 of 169
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Autophagy compensates for Lkb1 loss to maintain adult mice homeostasis and survival

    Khoosheh Khayati, Vrushank Bhatt ... Jessie Yanxiang Guo
    Autophagy and Lkb1 work synergistically to maintain adult mouse homeostasis and survival.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Rationally derived inhibitors of hepatitis C virus (HCV) p7 channel activity reveal prospect for bimodal antiviral therapy

    Joseph Shaw, Rajendra Gosain ... Stephen Griffin
    Exploiting virus-encoded ion channels as drug targets drove a multi-faceted approach to deriving potent small molecules targeting HCV p7, simultaneously providing new insights into its fundamental biology.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Genetic Engineering: Increasing the uptake of carbon dioxide

    Eric Franklin, Martin Jonikas
    A mechanism for concentrating carbon dioxide has for the first time been successfully transferred into a species that lacks such a process.
    Version of Record
    Insight
    1. Microbiology and Infectious Disease

    Glutamine metabolism modulates azole susceptibility in Trypanosoma cruzi amastigotes

    Peter C Dumoulin, Joshua Vollrath ... Barbara Burleigh
    Trypanosoma cruzi intracellular amastigotes exhibit rapid resistance to azoles, independent of genetic selection, which is dependent on metabolic state and mechanistically distinct from latency.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Structural ordering of the Plasmodium berghei circumsporozoite protein repeats by inhibitory antibody 3D11

    Iga Kucharska, Elaine Thai ... Jean-Philippe Julien
    A comprehensive structural analysis of inhibitory murine antibody 3D11 binding to Plasmodium berghei circumsporozoite protein reveals common mechanisms of antibody evolution in mammals against Plasmodium parasites.
    1. Ecology
    2. Microbiology and Infectious Disease

    Metapopulation ecology links antibiotic resistance, consumption, and patient transfers in a network of hospital wards

    Julie Teresa Shapiro, Gilles Leboucher ... Jean-Philippe Rasigade
    Patterns of antibiotic use and the connectivity between wards are independently associated with the incidence of antimicrobial-resistant infections in hospital networks.
    1. Ecology
    2. Microbiology and Infectious Disease

    Antibiotics: Modelling how antimicrobial resistance spreads between wards

    Tjibbe Donker
    Moving patients between wards and prescribing high levels of antibiotics increases the spread of bacterial infections that are resistant to treatment in hospitals.
    Version of Record
    Insight
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Structures of diverse poxin cGAMP nucleases reveal a widespread role for cGAS-STING evasion in host–pathogen conflict

    James B Eaglesham, Kacie L McCarty, Philip J Kranzusch
    Poxin enzymes are a diverse family of insect and viral 2′3′-cGAMP nucleases, which evolved from self-cleaving RNA virus accessory proteases.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Inhibition of SARS-CoV-2 viral entry upon blocking N- and O-glycan elaboration

    Qi Yang, Thomas A Hughes ... Sriram Neelamegham
    A critical role for glycosylation on viral entry and methods to use this knowledge to reduce SARS-CoV-2 infectivity has been demonstrated.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    A motogenic GABAergic system of mononuclear phagocytes facilitates dissemination of coccidian parasites

    Amol K Bhandage, Gabriela C Olivera ... Antonio Barragan
    Intracellular parasites hijack a conserved GABAergic system of immune cells to promote dissemination.