Microbiology and Infectious Disease

Latest articles

1. 1. Microbiology and Infectious Disease

   Pathogen-phage geomapping to overcome resistance

   Camilla Do, Keiko Christine Salazar ... Anthony W Maresso

   Targeted ecological sampling combined with a portable enrichment device rapidly yields a diverse array of bacteriophages against drug-resistant pathogens.
2. 1. Microbiology and Infectious Disease

   Nanoscopy reveals heparan sulfate clusters as docking sites for SARS-CoV-2 attachment and entry

   Sue Han, Xin Wang ... Ling-Gang Wu

   Cell-surface heparan sulfate clusters, not the generally assumed ACE2, mediate SARS-CoV-2 attachment and endocytic entry, fundamentally revising the viral entry paradigm and establishing heparan sulfate as a primary therapeutic target.
3. 1. Microbiology and Infectious Disease

   High-throughput quantification of population dynamics using luminescence

   Malte Muetter, Daniel C Angst ... Sebastian Bonhoeffer

   Tracking luminescent reporter light intensity is a fast, easy way to quantify population decline at high concentrations and tends to be a better proxy for biomass than for cell number.
4. 1. Microbiology and Infectious Disease

   Apparent cooperativity between human CMV virions introduces errors in conventional methods of calculating multiplicity of infection

   Christopher Peterson, Joshua Miller ... Vitaly V Ganusov

   Cooperation between individual virions of human cytomegalovirus at infecting cells leads to nonlinear scaling of cell infection probability with virion concentration.
5. 1. Microbiology and Infectious Disease

   Niche exclusion of a lung pathogen in mice with designed probiotic communities

   Kelsey E Hern, Ashlee M Phillips ... Adam P Arkin

   Probiotic communities designed to inhibit a lung pathogen through niche exclusion show promise as a novel method of preventing respiratory infection.
6. 1. Microbiology and Infectious Disease

   Multidimensional in vitro assay for antimalarial combination testing and pharmacodynamic modeling – the MULT-i² assay

   Angela Hellingman, Christin Gumpp ... Matthias Rottmann
7. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   Reprogramming of host energy metabolism mediated by the TNF-iNOS-HIF-1α axis plays a key role in host resistance to Plasmodium infection

   Kely Catarine Matteucci, Nathalia PS Leite ... Ricardo T Gazzinelli

   TNF-driven metabolic reprogramming enhances glucose utilization in monocytes through inducible nitric oxide synthase (iNOS) and hypoxia-inducible factor 1α (HIF-1α), promoting parasite control and host resistance during Plasmodium infection.
8. 1. Microbiology and Infectious Disease

   An abundant merozoite surface protein of Plasmodium falciparum modulates susceptibility to inhibitory antibodies

   Isabelle G Henshall, Jill Chmielewski ... Danny W Wilson

   Pathogens can use surface proteins to limit immune responses, and the finding that merozoite surface protein 2 has this property could help in Plasmodium falciparum malaria vaccine development.
9. 1. Microbiology and Infectious Disease

   Three metabolic pathways replenishing the one-carbon pool collectively support growth and virulence of Listeria monocytogenes

   Sandra Freier, Sarah Frentzel ... Sven Halbedel
10. 1. Cell Biology
    2. Microbiology and Infectious Disease

    Enteropathogenic Escherichia coli-mediated fast and coordinated Ca^²+ responses regulate NF-κB activation

    Fangrui Guo, Roberto Ornelas Guevara ... Guy Tran Van Nhieu

    Through low levels of extracellular ATP, EPEC induces small, rapid and coordinated Ca²⁺ responses in epithelial cells, a yet unreported pattern, that down-regulate inflammation at the onset of infection.