Browse our latest Neuroscience articles

Page 173 of 608
    1. Neuroscience

    On the normative advantages of dopamine and striatal opponency for learning and choice

    Alana Jaskir, Michael J Frank
    A computational model of the opponent neural architecture the basal ganglia, in tandem with adaptive dopamine modulation, exhibits robust advantages over traditional learning algorithms and ties together seemingly aberrant behavioral patterns resulting from dopamine and environmental manipulations across species.
    1. Neuroscience

    Early myelination involves the dynamic and repetitive ensheathment of axons which resolves through a low and consistent stabilization rate

    Adam R Almeida, Wendy B Macklin
    Oligodendrocytes iteratively wrap and unwrap the same domain of an axon multiple times during development, which likely impacts myelin sheath stabilization.
    1. Developmental Biology
    2. Neuroscience

    Origin of wiring specificity in an olfactory map revealed by neuron type–specific, time-lapse imaging of dendrite targeting

    Kenneth Kin Lam Wong, Tongchao Li ... Liqun Luo
    Advanced genetics and imaging reveal wiring logic underlying the olfactory map organization in the developing fruit fly brain, and strategies employed by projection neurons to target dendrites to specific locations in a timely manner.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Cannabidiol sensitizes TRPV2 channels to activation by 2-APB

    Aaron Gochman, Xiao-Feng Tan ... Andres Jara-Oseguera
    Cannabidiol is an ultra potent sensitizer for 2-APB responses in rTRPV2 and mTRPV3 channels but not in rTRPV1 through a mechanism that engages channel regions further from the cannabidiol binding site and the pore.
    1. Neuroscience

    Cerebellar Activation Bidirectionally Regulates Nucleus Accumbens Core and Medial Shell

    Alexa F. D’Ambra, Ksenia Vlasov ... Diasynou Fioravante
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    Antisense, but not sense, repeat expanded RNAs activate PKR/eIF2α-dependent ISR in C9ORF72 FTD/ALS

    Janani Parameswaran, Nancy Zhang ... Jie Jiang
    C9ORF72 antisense repeat expanded RNAs activate PKR/eIF2α dependent integrated stress response and cause neuronal toxicity independent of DPR proteins.
    1. Developmental Biology
    2. Neuroscience

    linc-mipep and linc-wrb encode micropeptides that regulate chromatin accessibility in vertebrate-specific neural cells

    Valerie A Tornini, Liyun Miao ... Antonio J Giraldez
    Two putative long noncoding RNAs in zebrafish encode micropeptides with homology to the vertebrate-specific chromatin architectural protein, Hmgn1, which are required for development of vertebrate-specific brain cell types.
    1. Neuroscience

    Innate Behavior: A groom with a view

    Jeffrey E Markowitz
    Mapping mouse grooming episodes to neural activity shows that striatal cells deep in the brain collectively represent key aspects of self-grooming.
    Version of Record
    Insight
    1. Immunology and Inflammation
    2. Neuroscience

    MHC class I and MHC class II reporter mice enable analysis of immune oligodendroglia in mouse models of multiple sclerosis

    Em P Harrington, Riley B Catenacci ... Peter A Calabresi
    Oligodendroglia express major histocompatibility complex (MHC) pathways in response to inflammation and MHC reporter mice allow for the investigation of MHC molecule expressing cells in vivo.
    1. Medicine
    2. Neuroscience

    Biological brain age prediction using machine learning on structural neuroimaging data: Multi-cohort validation against biomarkers of Alzheimer’s disease and neurodegeneration stratified by sex

    Irene Cumplido-Mayoral, Marina García-Prat ... OASIS study
    Brain-Age delta is a non-invasive marker of biological brain aging that is sensitive to the presence of risk factors and altered biomarkers of Alzheimer's disease in non-demented individuals.