Maximilian Lenz, Amelie Eichler ... Andreas Vlachos
All-trans retinoic acid increases the number of excitatory synapses in the dorsal hippocampus of mice and improves the ability of neurons to express synaptopodin-dependent synaptic plasticity.
In economic choices under variable action costs, in contrast to the orbitofrontal cortex, dorsal anterior cingulate cortex represents not pre-decision but post-decision variables, thus might inform subsequent actions based on reward and effort associated with the choice outcomes.
Melanie Holmgren, Michael E Ravicz ... Lavinia Sheets
Mechanically induced injury of zebrafish lateral-line organs shares key features of damage observed in noise-exposed mammalian ears, such as inflammation and synapse loss, yet, unlike mammals, rapidly repairs following damage.
Mechanically activated Piezo1 ion channels, at physiologically relevant densities, behave as independent mechanotransducers, which we propose is essential for homogenous transduction of forces across the entire cell membrane.
People use vmPFC-dependent forward thinking to guide social choices and exploit the controllability of social environments, expanding the role of this neurocomputational mechanism beyond spatial and cognitive mapping.
Fast network oscillations in the mammalian main olfactory bulb emerge from the dense synchronization of gamma-frequency firing among resonant tufted cells.
Jakob Jordan, Maximilian Schmidt ... Mihai A Petrovici
Artificial evolution discovers biophysically plausible plasticity rules for spiking networks that perform competitively with and even outperform labor-intensive human-designed models in various learning scenarios, while providing new views on experimental data.
Striatal cholinergic interneurons and astrocytes lose cilia and show dysregulation of Hedgehog signaling in mice with a Parkinson's disease-associated, G2019S LRRK2 mutation or upon loss of PPM1H phosphatase specific for LRRK2-phosphorylated Rab GTPases.
