Arpiar Saunders, Adam J Granger, Bernardo L Sabatini
Neurons of the cholinergic system, which release the excitatory neurotransmitter acetycholine throughout the cortex, also release the inhibitory transmitter GABA, with potential implications for cognitive function.
Stephanie J Papp, Anne-Laure Huber ... Katja A Lamia
The circadian clock proteins, cryptochrome 1 (Cry1) and 2 (Cry2), evolved from bacterial light-activated DNA repair enzymes to detect DNA damage and coordinate the gene expression response.
Variations in the frequency of theta brain waves enable a single network of brain regions to generate appropriate responses to stimuli with different kinds of emotional value.
After shaking hands with a stranger, human volunteers often subliminally bring their hand to their nose and sniff it, possibly to collect important olfactory information.
Hermann C Altmeppen, Johannes Prox ... Markus Glatzel
A lack of ADAM10-mediated shedding increases prion protein levels at the plasma membrane and promotes the generation of pathological prion proteins, which accelerates prion disease in mice.
Carmela Sidrauski, Anna M McGeachy ... Peter Walter
Building on previous work which showed that the small molecule ISRIB potently blocks the integrated stress response (Sidrauski et al., 2013), we report on ISRIB's remarkable specificity and fast action in vivo, underscoring its proposed direct effect on translation.
Stephan Heermann, Lucas Schütz ... Joachim Wittbrodt
The lens-averted domains of the optic vesicle are reservoirs of neuroretinal cells that flow into the developing optic cup in a process that is critically influenced by BMP signaling.
