Browse our latest Stem Cells and Regenerative Medicine articles

Ablation of canonical TGFβ signaling in muscle stem cells at any age is detrimental, and not beneficial, to effective skeletal muscle regeneration due to the promotion of premature fate commitment at the expense of progenitor amplification.

Identification of Hematopoietic stem cells (HSCs) in the genetically amenable organism Drosophila melanogaster paves the path to address HSC biology, both in normal and pathophysiological conditions.

Two methyl-binding domain proteins have interdependent functions in embryonic stem cells, and this interdependency extends to the DNA methylation/hydroxymethylation machinery.

The conserved mechanism of Notch down-regulation by endo-lysosomal trafficking plays important roles in the proliferation and differentiation of stem and progenitor cells during embryogenesis or organogenesis in vertebrates.

Analyzing the readout of Notch signaling with single RNA precision reveals that active transcription sites are the most accurate measure of Notch-dependent transcriptional activation.

Building on previous work (Dye et al., 2015) showing that pluripotent stem cell derived lung organoids were immature/fetal, the current study shows that in vivo transplantation leads to mature tissue, reminiscent of adult airways.

Long-term live imaging reveals the dynamic cell behaviors and progenitor cells that underpin the regeneration of adult limbs in the crustacean Parhyale hawaiensis.

For skeletal muscle in mice, the size of the stem cell pool can be uncoupled from overall tissue size allowing for a dramatic increase in stem cell number.