Browse our latest Structural Biology and Molecular Biophysics articles

Cryo-EM, Molecular Dynamics, and in vitro binding assays are combined to elucidate a new occluded conformation associated with zinc binding and energy coupling with the proton motive force.

The enterococcal adhesin PrgB consists of four immunoglobulin-like domains that support the proper function of its polymer adhesin domain.

Biochemical, structural, imaging, and functional studies reveal how the ESCRT-III protein IST1 recruits the CAPN7 cysteine protease to midbodies, where its proteolytic activity is required for efficient abscission and NoCut checkpoint arrest.

Functional studies on CFTR anion channels harboring combinations of catalytic site mutations in the active ATPase site reveal the true stability of the prehydrolytic open-pore state as well as nucleotide-binding domain interface features that are unique to human CFTR.

Many channelrhodopsins acidify cells, but two new ones do not.

A designer peptide inhibits the T cell receptor through allosteric binding to the transmembrane region.

Revisiting limitations in time-resolved X-ray free-electron laser structures of the bacterial photosynthetic reaction center uncovers their irrelevance to proposed structural changes in electron transfer dynamics.

A single conserved residue – histidine 12 – confers pH-sensitive DNA binding to the Salmonella Typhimurium SPI-2 transcriptional regulator SsrB, thereby regulating Salmonella virulence.

Investigations of the reaction center (RC)-light harvesting (LH) complex from an ancient chlorosome-less anoxygenic phototroph Roseiflexus castenholzii reveal the structural basis by which carotenoids assembly regulates the architecture and quinone exchange of bacterial RC-LH complex.

CaMKII and the actin-crosslinking protein α-actinin-2 associate within minutes of the induction of long-term potentiation and disrupting this interaction prevents formation of enlarged dendritic spines.