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The identification of 20 causal plasma proteins for prostate cancer represents a critical step toward addressing the need for improved diagnostic specificity and reveals promising new targets for therapeutic intervention.

Epigenetic and metabolic programming of innate immune cells shapes host defense and disease susceptibility.

Cavefish exhibit resilience to chronic sleep loss and tolerate elevated DNA damage and reduced DNA repair responses without compromising healthspan or longevity.

The hold-and-release regulation of zinc by GIF/MT-3 is mediated by sulfane sulfur through a redox-dependent switching mechanism.

Multimodal neuroimaging explained 66% of the cognitive–mental health link in children, outperforming polygenic scores (21%), and accounted for 58% of the environmental contribution to this relationship.

Membrane depolarization promotes extracellular signal-regulated kinase activation and cell proliferation via phosphatidylserine dynamics.

Integration of migrasome-inspired biology with hypotonic shock-mediated vesicle generation establishes a durable and versatile platform for vaccine development.

Classical antibody boosting effects during vaccination are accompanied by natural broadening mechanisms that help enable human antibodies to engage conserved sites of vulnerability on influenza virus.

Distinct asymmetric states in membrane-bound pyrophosphatases reveal how inhibitors block their activity and inform drug development.