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    1. Developmental Biology
    2. Genetics and Genomics

    PIK3CA-related overgrowth spectrum (PROS) zebrafish models reveal pan-lineage developmental dysregulation

    Hannah Brunsdon, Nuoya Wang ... E Elizabeth Patton
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    • Convincing
    1. Epidemiology and Global Health

    Understanding Pain in Polycystic Ovary Syndrome: Health Risks and Treatment Effectiveness

    Tess Cherlin, Stephanie Mohammed ... Shefali S Verma
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Compelling
    1. Neuroscience

    Experience shapes the transformation of olfactory representations along the cortico-hippocampal pathway

    Eleonore Schiltz, Martijn Broux ... Haesler Sebastian
    The representation of stimulus identity and experience is transformed from primary olfactory cortex to memory-related multisensory areas in the hippocampus.
    Version of Record
    Short Report
    • Important
    • Solid
    1. Cell Biology

    Capsaicin acts as a novel NRF2 agonist to suppress ethanol induced gastric mucosa oxidative damage by directly disrupting the KEAP1-NRF2 interaction

    Xiaoning Gao, Wuyan Guo ... Jun Kang
    Non-covalent targeting of KEAP1 by capsaicin provides a reversible and safe NRF2 agonist for treating oxidative damage.
    1. Developmental Biology
    2. Neuroscience

    Complementary vertebrate Wac models exhibit phenotypes relevant to DeSanto-Shinawi Syndrome

    Kang-Han Lee, April M Stafford ... Daniel Vogt
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Evolutionary Biology

    Experimental evolution to thermal stress indicates climate resilience in a cosmopolitan arthropod

    Gaoke Lei, Huiling Zhou ... Shijun You
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience

    Developmental Synchrony of Retinal Waves, Apoptosis, and Angiogenesis in Postnatal Retina

    Michael A Savage, Cori Bertram ... Evelyne Sernagor
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Structural Biology and Molecular Biophysics

    Characterization and modulation of human insulin degrading enzyme conformational dynamics to control enzyme activity

    Jordan M Mancl, Wenguang G Liang ... Wei-Jen Tang
    Integrative structural analysis identifies the structural basis and key residues responsible for IDE conformational dynamics that control the unfolding and selective degradation of amyloid peptides.
    1. Chromosomes and Gene Expression

    Uncoupling the TFIIH Core and Kinase Modules leads to misregulated RNA polymerase II CTD Serine 5 phosphorylation

    Gabriela Giordano, Robin Buratowski ... Stephen Buratowski
    The TFIIH subunit Tfb3/MAT1 can be split into two parts to uncouple the TFIIH kinase and DNA translocase modules, resulting in unfocused C-terminal domain phosphorylation.
    1. Neuroscience

    A comprehensive mechanosensory connectome reveals a somatotopically organized neural circuit architecture controlling stimulus-aimed grooming of the Drosophila head

    Steven A Calle-Schuler, Alexis Santana-Cruz ... Andrew M Seeds
    A synaptic-resolution map reveals how spatially organized touch pathways in the fly brain shape aimed head grooming through parallel excitatory circuits and inhibitory control.
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