Intermittent fasting affects intestinal immunity through new interactions between macrophages and ILC3s, increasing ILC3 secretion of IL-22 and thus promoting white adipose tissue beigeing, and improving metabolism.
Mouse models reveal fundamental roles of SMAD1/5 in mediating both bone morphogenetic protein signaling pathways and the transcriptional response to progesterone during decidualization.
Mendelian randomization and transcriptome-wide association studies delineate the causal relationships and genetic markers between circulating immune cells and periodontitis, pinpointing neutrophils as the predominant contributors.
New ATP-competitive inhibitors show properties of conformation selection when complexed with the MAP kinase, ERK2, altering movements around the activation loop.
A microfluidic device induces doxorubicin-resistant polyaneuploid cancer cells from triple negative breast cancer cells, revealing NUPR1/HDAC11 axis dysfunction drives chemoresistance, increasing tumor heterogeneity and impacting clinical outcomes.
The transmembrane protein Kit Ligand and the Kit receptor tyrosine kinase are required for synapse function between specific cell types in the mouse cerebellum.
Measurement of the effect of all single-codon variants of the AAV2 rep gene on recombinant adeno-associated virus production identifies novel beneficial variants, which may facilitate improvement of gene therapy production.
Karolina Honzejkova, Dalibor Kosek ... Tomas Obsil
Thioredoxin functions as a negative allosteric effector of ASK1 by altering the interaction between the thioredoxin-binding and tetratricopeptide repeats domains, thereby reducing access to the kinase domain's activation segment.
