Browse our latest research

Page 3 of 1,234
    1. Neuroscience

    Phox2b mutation mediated by Atoh1 expression impaired respiratory rhythm and ventilatory responses to hypoxia and hypercapnia

    Caroline B Ferreira, Talita M Silva ... Thiago S Moreira
    New evidence for the impaired breathing activity is related to non-polyalanine repeat expansion mutations form of congenital central hypoventilation syndrome neuropathology.
    1. Genetics and Genomics

    Brown adipocytes local response to thyroid hormone is required for adaptive thermogenesis in adult male mice

    Yanis Zekri, Romain Guyot ... Karine Gauthier
    T3 regulates BAT thermogenesis by controlling the expression of genes involved in the management of metabolic fuels as well as tissue plasticity.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Landscape of epithelial–mesenchymal plasticity as an emergent property of coordinated teams in regulatory networks

    Kishore Hari, Varun Ullanat ... Mohit Kumar Jolly
    Investigation of regulatory network topology reveals latent design principles of multistable phenotypic landscape.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Polygenic adaptation after a sudden change in environment

    Laura Katharine Hayward, Guy Sella
    A shift in fitness optimum of a polygenic trait rapidly introduces small frequency differences between alleles with effects aligned with and opposing the shift, which gradually translate into small differences in fixation probability.
    1. Neuroscience

    Centrally expressed Cav3.2 T-type calcium channel is critical for the initiation and maintenance of neuropathic pain

    Sophie L Fayad, Guillaume Ourties ... Nathalie Leresche
    1. Physics of Living Systems

    Phenotyping single-cell motility in microfluidic confinement

    Samuel A Bentley, Hannah Laeverenz-Schlogelhofer ... Kirsty Y Wan
    A droplet microfluidics approach to stably trap and phenotype individual micron-sized algae reveals their distinct but stereotyped movement patterns and how they respond in real time to local environmental cues, including novel boundary circling behaviour under strong confinement.
    1. Ecology
    2. Microbiology and Infectious Disease

    Variation in the ACE2 receptor has limited utility for SARS-CoV-2 host prediction

    Nardus Mollentze, Deborah Keen ... Daniel G Streicker
    The success of angiotensin-converting enzyme 2 (ACE2)-based predictions of severe acute respiratory syndrome-associated virus 2 (SARS-CoV-2) host range stems from phylogenetic correlation, allowing development of scalable models which predict susceptibility to SARS-CoV-2 and other sarbecoviruses without requiring additional ACE2 sequencing.
    1. Cell Biology

    A general approach for stabilizing nanobodies for intracellular expression

    John G Dingus, Jonathan CY Tang ... Constance L Cepko
    A large proportion of nanobodies are unstable when expressed intracellularly, but can be reliably stabilized for intracellular expression by applying a generalizable mutagenesis strategy based on positional sequence conservation.