Browse our latest research

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    1. Cell Biology
    2. Medicine

    Lymphangiogenic therapy prevents cardiac dysfunction by ameliorating inflammation and hypertension

    LouJin Song et al.
    Lymphangiogenic therapy VEGFCc156s improved angiotensin-II-induced impairments in heart function via novel mechanisms, which include transcriptional responses to alleviate inflammation and cardiac fibrosis, and systemic responses to ameliorate hypertension.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Opposing JAK-STAT and Wnt signaling gradients define a stem cell domain by regulating differentiation at two borders

    David Melamed, Daniel Kalderon
    Graded Wnt and JAK-STAT signals regulate the division rate, AP location and differentiation of Drosophila ovarian follicle stem cells to define a domain of stem cells maintained by population asymmetry.
    1. Neuroscience

    Frontal eye field and caudate neurons make different contributions to reward-biased perceptual decisions

    Yunshu Fan et al.
    In monkeys making decisions that balance noisy evidence and reward expectation, frontal cortical and caudate activity reflect different computational components that are related to the monkeys' strategy.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Increasing heart vascularisation after myocardial infarction using brain natriuretic peptide stimulation of endothelial and WT1+ epicardial cells

    Na Li et al.
    Brain natriuretic peptide supplementation can increase cardiac neovascularization in infarcted hearts by stimulating endogenous endothelial cell proliferation and proliferation of precursor cells, which will differentiate into endothelial cells.
    1. Biochemistry and Chemical Biology

    Bacterial OTU deubiquitinases regulate substrate ubiquitination upon Legionella infection

    Donghyuk Shin et al.
    A novel class of bacterial OTU deubiquitinases provides insights on the distinct roles of bacterial deubiquitinases in host–pathogen interactions.
    1. Ecology
    2. Microbiology and Infectious Disease

    Metapopulation ecology links antibiotic resistance, consumption, and patient transfers in a network of hospital wards

    Julie Teresa Shapiro et al.
    Patterns of antibiotic use and the connectivity between wards are independently associated with the incidence of antimicrobial-resistant infections in hospital networks.
    1. Immunology and Inflammation

    CD14 release induced by P2X7 receptor restricts inflammation and increases survival during sepsis

    Cristina Alarcón-Vila et al.
    A murine model of sepsis shows that the purinergic P2X7 receptor controls the release of CD14 in extracellular vesicles playing a key role in cytokine production, bacterial clearance, and survival.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Control of Slc7a5 sensitivity by the voltage-sensing domain of Kv1 channels

    Shawn M Lamothe et al.
    The voltage-sensing mechanism of a subfamily of potassium channels is modulated in unconventional ways by an amino acid transporter.