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    1. Physics of Living Systems

    Cell strain-stiffening drives cell breakout from embedded spheroids

    Shabeeb Ameen, Kyungeun Kim ... Tao Zhang
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Layer-specific spatiotemporal dynamics of feedforward and feedback in human visual object perception

    Tony Carricarte, Siying Xie ... Radoslaw M Cichy
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    • Solid
    1. Neuroscience

    Cognitive control networks in human and macaque

    Valentina Mione, Freja Holm Prins ... John Duncan
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Structural Biology and Molecular Biophysics

    In-cell cryo-electron tomography reveals differential effects of type I and type II kinase inhibitors on LRRK2 filament formation and microtubule association

    Tamar Basiashvili, Joshua Hutchings ... Elizabeth Villa
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Epidemiology and Global Health
    2. Evolutionary Biology

    How local antibiotic use, carriage duration, resistance costs and international travel shape resistance frequency in E. coli in France

    Olivier Cotto, André Birgy ... François Blanquart
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Biochemistry and Chemical Biology

    De novo design of protein binders that target DELE1 to inhibit the mitochondrial stress response

    Rui Yang, Kaiyuan Zheng ... Jie Yang
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience

    Hierarchical priors enable neural prediction of perceived biological motion

    Ingmar EJ de Vries, Floris P de Lange, Moritz F Wurm
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Training neural networks from scratch in a videogame leads to brittle brain encoding

    François Paugam, Basile Pinsard ... Lune Bellec
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    • Incomplete
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Patient-specific midbrain organoids with CRISPR correction recapitulate neuronopathic Gaucher disease phenotypes and enable evaluation of novel therapies

    Yi Lin, Benjamin Liou ... Ying Sun
    Human midbrain organoids provide a foundation for the development of patient-specific preclinical models to support personalized therapeutic approaches and enable evaluation of disease mechanisms and therapeutic strategies in human context.
    1. Structural Biology and Molecular Biophysics

    Intraflagellar transport protein IFT172 contains a C-terminal ubiquitin-binding U-box-like domain involved in ciliary signaling

    Nevin K Zacharia, Stefanie Kuhns ... Esben Lorentzen
    The IFT172 C-terminus bridges IFT-A and IFT-B complexes through mutually exclusive interactions with IFT140 and IFT144, and harbors a U-box-like domain linking intraflagellar transport to ubiquitin-dependent ciliary signaling.
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