Browse our latest research

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    1. Cell Biology

    Actin-regulated Siglec-1 nanoclustering influences HIV-1 capture and virus-containing compartment formation in dendritic cells

    Enric Gutiérrez-Martínez, Susana Benet Garrab ... Maria F Garcia-Parajo
    1. Structural Biology and Molecular Biophysics

    Peptides that Mimic RS repeats modulate phase separation of SRSF1, revealing a reliance on combined stacking and electrostatic interactions

    Talia Fargason, Naiduwadura Ivon Upekala De Silva ... Jun Zhang
    Short peptides that mimic the regions responsible for phase separation can be used to solubilize phase-separating proteins in their native states and to determine the mechanism of phase separation.
    1. Neuroscience

    CaV1 and CaV2 calcium channels mediate the release of distinct pools of synaptic vesicles

    Brian D Mueller, Sean A Merrill ... Erik M Jorgensen
    The Caenorbhaditis elegans presynapse contains two pools of synaptic vesicles at the active zone, coupled to either neuronal-type or muscle-type calcium channels, and to different docking machinery.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    The long noncoding RNA Charme supervises cardiomyocyte maturation by controlling cell differentiation programs in the developing heart

    Valeria Taliani, Giulia Buonaiuto ... Monica Ballarino
    The lncRNA pCharme controls the expression of cardiomyocyte maturation genes and heart development by orchestrating the formation of MATR3-enriched nuclear condensates.
    1. Cancer Biology

    Kindlin-1 regulates IL-6 secretion and modulates the immune environment in breast cancer models

    Emily R Webb, Georgia L Dodd ... Valerie G Brunton
    New roles in anti-tumour immunity for the adhesion protein Kindlin-1 via regulation of cytokine secretion and T cell regulation.
    1. Cell Biology
    2. Neuroscience

    Large vesicle extrusions from C. elegans neurons are consumed and stimulated by glial-like phagocytosis activity of the neighboring cell

    Yu Wang, Meghan Lee Arnold ... Barth D Grant
    Giant neuron derived vesicles called exophers are processed by phagocytosis in neighboring skin cells, and the phagocytic interaction promotes exopher production.
    1. Cell Biology
    2. Genetics and Genomics

    Identification of a weight loss-associated causal eQTL in MTIF3 and the effects of MTIF3 deficiency on human adipocyte function

    Mi Huang, Daniel Coral ... Sebastian Kalamajski
    MTIF3 safeguards mitochondrial electron transport chain assembly in adipocytes, and affects thus adipocyte fatty acid oxidation ability, which can explain why MTIF3 genetic variation can influence dietary intervention aimed at weight loss.
    1. Epidemiology and Global Health

    Reducing societal impacts of SARS-CoV-2 interventions through subnational implementation

    Mark M Dekker, Luc E Coffeng ... Sake J de Vlas
    An agent-based, population-scale, geographically explicit model, and integration of comprehensive data sources on demography, mobility, interactions and SARS-CoV-2 parameters, show that subnational implementations of intervention measures may provide better strategic choices for controlling future epidemics.
    1. Neuroscience

    Netrin-1 regulates the balance of synaptic glutamate signaling in the adult ventral tegmental area

    Marcella M Cline, Barbara Juarez ... Larry S Zweifel
    Genetic analysis of Ntn1 in adult mouse midbrain neurons reveals its function in maintaining excitatory synapses, loss of Ntn1 function in inhibitory neurons is significantly detrimental to mesolimbic system function.