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Page 3 of 687
Genetics and Genomics
Stem Cells and Regenerative Medicine
Multiplex CRISPR/Cas screen in regenerating haploid limbs of chimeric Axolotls
Lucas D Sanor et al.
A novel CRISPR-based genetic screen of candidate regeneration genes in haploid axolotl limbs reveals two genes required for proper regeneration.
Human Biology and Medicine
Immunology and Inflammation
TLR5 participates in the TLR4 receptor complex and promotes MyD88-dependent signaling in environmental lung injury
Salik Hussain et al.
Structural Biology and Molecular Biophysics
Modulation of the
ligand-gated ion channel (ELIC) and the 5-HT
receptor via a common vestibule site
Marijke Brams et al.
A phenotypic screening platform utilising human spermatozoa identifies compounds with contraceptive activity
Franz S Gruber et al.
Learning improves decoding of odor identity with phase-referenced oscillations in the olfactory bulb
Justin Losacco et al.
Tetrode recordings show that the amplitude of gamma oscillations encodes for information on contextual odorant identity when observed at the peak phase of the theta oscillation in the olfactory bulb.
Epidemiology and Global Health
Microbiology and Infectious Disease
Zika seroprevalence declines and neutralizing antibodies wane in adults following outbreaks in French Polynesia and Fiji
Alasdair D Henderson et al.
A combination of eight serological surveys shows a decline in seroprevalence over a two-year period following the first reports of Zika transmission in Fiji and French Polynesia.
Integration of locomotion and auditory signals in the mouse inferior colliculus
Yoonsun Yang et al.
Genetics and Genomics
GLI transcriptional repression regulates tissue-specific enhancer activity in response to Hedgehog signaling
Rachel K Lex et al.
GLI3 represses Hedgehog target gene expression by regulating histone modifications at a subset of tissue-specific GLI-bound enhancers.
STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformation of human cells
Jong Wook Kim et al.
ST recruitment of STRIPAK facilitates PP2A-mediated dephosphorylation of MAP4K4 and induces cell transformation highlighting that STRIPAK complex plays a key role in defining PP2A specificity and activity.
Gab1 mediates PDGF signaling and is essential to oligodendrocyte differentiation and CNS myelination
Liang Zhou et al.
Gab1 is a key downstream effector of PDGF signaling and essential to oligodendrocyte differentiation by linking PDGF signaling with GSK3β/β-catenin module.
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