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Page 3 of 1,069
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Neurotoxin-mediated potent activation of the axon degeneration regulator SARM1

    Andrea Loreto et al.
    The identification of the mechanism of action of vacor, an environmental neurotoxin which causes neurodegeneration by activating the pro-degenerative enzyme SARM1, raises important questions on SARM1 as a mediator of environmental neurotoxicity and has implications for drug discovery.
    1. Cell Biology
    2. Immunology and Inflammation

    Robust T cell activation requires an eIF3-driven burst in T cell receptor translation

    Dasmanthie De Silva et al.
    Binding of the translation initiation factor eIF3 to the messenger RNAs encoding the T cell receptor subunits alpha and beta is required to drive a short burst in their translation and promote a strong T cell response.
    1. Cell Biology
    2. Medicine

    Hepatic MIR20B promotes nonalcoholic fatty liver disease by suppressing PPARA

    Yo Han Lee et al.
    MIR20B has a deteriorating effect in NAFLD by suppressing PPARA, and may serve as a therapeutic target for combination therapy with fenofibrate for NAFLD.
    1. Genetics and Genomics

    Disruption of PIKFYVE causes congenital cataract in human and zebrafish

    Shaoyi Mei et al.
    Deleterious genetic variants in the PIP kinase domain of PIKFYVE are directly associated with the occurrence of congenital cataract in human and zebrafish.