A shift in fitness optimum of a polygenic trait rapidly introduces small frequency differences between alleles with effects aligned with and opposing the shift, which gradually translate into small differences in fixation probability.
Samuel A Bentley, Hannah Laeverenz-Schlogelhofer ... Kirsty Y Wan
A droplet microfluidics approach to stably trap and phenotype individual micron-sized algae reveals their distinct but stereotyped movement patterns and how they respond in real time to local environmental cues, including novel boundary circling behaviour under strong confinement.
Nardus Mollentze, Deborah Keen ... Daniel G Streicker
The success of angiotensin-converting enzyme 2 (ACE2)-based predictions of severe acute respiratory syndrome-associated virus 2 (SARS-CoV-2) host range stems from phylogenetic correlation, allowing development of scalable models which predict susceptibility to SARS-CoV-2 and other sarbecoviruses without requiring additional ACE2 sequencing.
John G Dingus, Jonathan CY Tang ... Constance L Cepko
A large proportion of nanobodies are unstable when expressed intracellularly, but can be reliably stabilized for intracellular expression by applying a generalizable mutagenesis strategy based on positional sequence conservation.