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    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Interrogating the structure and function of the human voltage-gated proton channel (hHv1) with a fluorescent noncanonical amino acid

    Emerson M Carmona, William N Zagotta, Sharona E Gordon
    A fluorescent noncanonical amino acid enables structural measurements across full-length human voltage-gated proton channel (Hv1) and reveals zinc-dependent conformational changes.
    1. Evolutionary Biology

    Inference of germinal center evolutionary dynamics via simulation-based deep learning

    Duncan K Ralph, Athanasios G Bakis ... Frederick A Matsen
    Deep learning applied to B cell phylogenies reveals a simple, measurable curve relating receptor affinity to evolutionary fitness in germinal centers.
    1. Developmental Biology

    Arrayed single-gene perturbations identify drivers of human anterior neural tube closure

    Roya E Huang, Giridhar M Anand ... Sharad Ramanathan
    Revised
    Reviewed Preprint v2
    Updated
    • Landmark
    • Exceptional
    1. Neuroscience

    Neural categorization of visual words of alphabetic and non-alphabetic languages

    Guo Zheng, Shihui Han
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Biochemistry and Chemical Biology

    The Role of ATP Synthase Subunit e (ATP5I) in Mediating the Metabolic and Antiproliferative Effects of Metformin

    Guillaume Lefrançois, Emilie Lavallée ... Gerardo Ferbeyre
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Physics of Living Systems

    Quantifying Intracellular Mechanosensitive Response upon Spatially Defined Mechano-Chemical Triggering

    Elaheh Zare-Eelanjegh, Renard TM Lewis ... Tomaso Zambelli
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Medicine
    2. Neuroscience

    A non-human primate model of Amyotrophic Lateral Sclerosis

    Rachael HA Jones, Luciano Saieva ... Stuart N Baker
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Neuroscience

    Behavioral Signatures of Post-Decisional Attention in Preferential Choice

    Ariel Zylberberg, Ian Krajbich, Michael N Shadlen
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Neuroscience

    Circadian control of a sex-specific behaviour in Drosophila

    Sabrina Riva, M Fernanda Ceriani ... D Lorena Franco
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Convincing
    1. Genetics and Genomics
    2. Immunology and Inflammation

    GM-CSF regulates ILC states and myeloid cell signaling during ulceration in Crohn’s disease

    Joshua K Morrison, Ksenija Sabic ... Ling-shiang Chuang
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
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