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    1. Evolutionary Biology

    Experimental evolution to thermal stress indicates climate resilience in a cosmopolitan arthropod

    Gaoke Lei, Huiling Zhou ... Shijun You
    Long-term thermal selection in Plutella xylostella drives coordinated genetic, epigenetic, and metabolic adaptations that enhance climate resilience, revealing mechanisms potentially shared across arthropod pests.
    1. Medicine
    2. Immunology and Inflammation

    A surviving beta cell subpopulation enriched in patients with T1D

    Maxwell Spurrell, John S Tsang, Kevan C Herold
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Ecology

    Stage-Specific Threats Reveal the Inadequacy of Adult-Centered Conservation

    Yanfang Song, Yongle Wang ... Weiwei Zhou
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Neuroscience

    LiFE, a multimodal circadian intervention, improves sleep, glycemic control, and recognition memory

    Yu Shi, Stephen D Rozen ... Ali D Güler
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Structural Biology and Molecular Biophysics

    In-cell cryo-electron tomography reveals differential effects of type I and type II kinase inhibitors on LRRK2 filament formation and microtubule association

    Tamar Basiashvili, Joshua Hutchings ... Elizabeth Villa
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience

    Meaning-based guidance of attention in rhesus monkeys during naturalistic scene viewing

    Orhan Soyuhos, Taylor R Hayes ... Xiaomo Chen
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience

    Tonic feedback motor commands predict visuomotor learning

    Yuto Makino, Toshiki Kobayashi, Daichi Nozaki
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Immunology and Inflammation

    Direct contact between iPSC-derived macrophages and hepatocytes drives reciprocal acquisition of Kupffer cell identity and hepatocyte maturation

    Christopher Zhe Wei Lee, Farah Tasnim ... Florent Ginhoux
    Co-culturing pluripotent stem cell-derived hepatocytes and macrophages establishes a physiologically relevant liver model that captures macrophage–hepatocyte interactions, significantly improves hepatocyte maturation, and enables more accurate prediction of immune-mediated drug toxicity.
    1. Cell Biology
    2. Developmental Biology

    Desert Hedgehog mediates stem Leydig cell differentiation through Ptch2/Gli1/Sf1 signaling axis

    Changle Zhao, Yongxun Chen ... Jing Wei
    Desert Hedgehog signaling promotes stem Leydig cell differentiation through a Ptch2-Gli1-Sf1 regulatory axis in Nile tilapia.
    1. Neuroscience

    Retrosplenial cortex enables context-dependent goal-directed sensorimotor transformation

    Pol Bech, Robin F Dard ... Carl CH Petersen
    Optical imaging and optogenetic inactivation of dorsal mouse neocortex reveal an unexpected role for retrosplenial cortex in the context-dependent transformation of whisker sensory information into licking for a water reward.
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