Browse our latest research

Page 2 of 1,840
    1. Genetics and Genomics

    Adapting Clinical Chemistry Plasma as a Source for Liquid Biopsies

    Spencer C Ding, Jingru Yu ... Wei Gu
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Immunology and Inflammation

    Contrasting roles for IKK-regulated inflammatory signalling pathways for development and maintenance of type 1 and adaptive γδ T cells

    Farjana Islam, Cayman Williams ... Benedict Seddon
    Inhibitor of κB kinase signalling differentially controls development and survival of γδ T cell subsets through nuclear factor-κB activation and repression of receptor-interacting protein kinase 1-driven necroptosis, revealing distinct inflammatory signalling requirements from αβ T cells.
    1. Neuroscience

    Stimulus dependencies—rather than next-word prediction—can explain pre-onset brain encoding in naturalistic listening designs

    Inés Schönmann, Jakub Szewczyk ... Micha Heilbron
    The ability to predict brain activity from words before they occur can be explained by information shared between neighbouring words, without requiring next-word prediction by the brain.
    1. Neuroscience

    Principles of gamma synchrony predict figure–ground perception in texture stimuli

    Maryam Karimian, Mark Jonathan Roberts ... Mario Senden
    Principles of weakly coupled oscillators capture human figure-ground segregation and its training-induced enhancement, indicating gamma synchrony remains a plausible grouping mechanism.
    1. Neuroscience

    Translational control in the spinal cord regulates gene expression and pain hypersensitivity in the chronic phase of neuropathic pain

    Kevin C Lister, Calvin Wong ... Arkady Khoutorsky
    Spinal translational control mechanisms regulate gene expression and nociceptive circuit sensitization during the chronic phase of neuropathic pain.
    1. Cell Biology

    GTPase-activating protein DLC1 spatio-temporally regulates Rho signaling

    Lucien Hinderling, Max Heydasch ... Olivier Pertz
    Mechanosensitive recruitment of DLC1 to focal adhesions creates a positive feedback loop that locally amplifies Rho activation in response to tension.
    1. Cancer Biology

    Loss of ZNRF3/RNF43 unleashes EGFR in cancer

    Fei Yue, Amy T Ku ... Yi Li
    Genetic and biochemical analyses show that loss of the E3 ubiquitin ligases ZNRF3 and RNF43 enhances EGFR signaling by impairing EGFR ubiquitination and degradation, revealing a new cancer-promoting mechanism.
    1. Developmental Biology

    Genetically engineered ESC-derived embryos reveal Vinculin-dependent force responses required for mammalian neural tube closure

    Ian S Prudhomme, Eric R Brooks ... Jennifer A Zallen
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Evolutionary Biology

    Design and experimental characterization of specificity-switching mutational paths of WW domains

    Ahmed Rehan, Eugenio Mauri ... Simona Cocco
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience

    Separation slang – Laboratory mice use low-frequency call repertoire during physical separation

    Daniel Breslav, Michal Wojcik ... Thorsten Becker
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete