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    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Targeting tankyrase scaffolding in the β-catenin destruction complex by PROTAC overcomes the limitation of catalytic inhibitors in cancer

    Qian Wang, Liping Li ... Chuo Chen
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Cell Biology

    Opto-MDMi: a dual-lock optogenetic system for robust activation of endogenous p53

    Tatsuki Tsuruoka, Takashi Sumikama ... Kazuhiro Aoki
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    • Incomplete
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Distinct prokaryotic gut microbiome and proviral-immune axes of pathophysiology in Sickle Cell Disease

    Zachary N Flamholz, Jennifer De Los Santos ... Libusha Kelly
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Microbiology and Infectious Disease

    Unexpected plasticity in the life cycle of Trypanosoma brucei

    Carina Praisler, Jaime N Lisack ... Markus Engstler
    Revised
    Reviewed Preprint v3
    Updated
    • Fundamental
    • Solid
    1. Genetics and Genomics

    The cistrome response to hypoxia in human umbilical vein endothelial cells

    Ayush Singh, Viktor Pastukh ... Hank W Bass
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Developmental Biology

    Comparative single-cell transcriptomic roadmap of mammalian fetal ovarian development

    Yifei Fang, Shiyao Han ... Jingyue Ellie Duan
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Cell Biology
    2. Microbiology and Infectious Disease

    A mitochondrial quality control mechanism reverses the phagosome maturation arrest caused by Mycobacterium tuberculosis

    Surbhi Verma, Shweta Thakur ... Dhiraj Kumar
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    The openretina Project: Collaborative Retina Modelling Across Datasets and Species

    Federico D’Agostino, Thomas Zenkel ... Matthias Bethge
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    The adaptive landscapes of three global Escherichia coli transcriptional regulators

    Cauã Antunes Westmann, Leander Goldbach, Andreas Wagner
    Across three global Escherichia coli regulators, identical starting sequences can evolve toward many distinct strong-binding peaks, with chance, historical contingency, and evolutionary bias shaping which outcomes prevail.
    1. Developmental Biology

    Single-cell characterization of anterior segment development in the mouse reveals the cell types, pathways, and signals driving formation of the trabecular meshwork and Schlemm’s canal

    Revathi Balasubramanian, Nicholas Tolman ... Simon WM John
    High-resolution single-cell transcriptomics reveals the molecular programs and signaling networks driving Schlemm's canal and trabecular meshwork development, establishing a foundation for understanding glaucoma pathogenesis.
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