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    1. Neuroscience

    Orco regulates the circadian activity of pheromone-sensitive olfactory receptor neurons in hawkmoths

    Aditi Vijayan, Mauro Forlino ... Monika Stengl
    Revised
    Reviewed Preprint v4
    Updated
    • Valuable
    • Solid
    1. Ecology
    2. Evolutionary Biology

    Life-history trade-offs explain local adaptation in Arabidopsis thaliana

    Benjamin Brachi, Danièle L Filiault ... Magnus Nordborg
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Genetics and Genomics
    2. Neuroscience

    Learning is a fundamental source of individuality

    Riddha Manna, Johanni Brea ... Ana Marija Jakšić
    Beyond genotype × environment interactions, which can be shared and identical across individuals, learning from uniquely individual experiences further defines and diversifies individual behaviour.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Gβγ engages PLCβ3 at multiple sites to reorient and facilitate its activation

    Isaac J Fisher, Kanishka Senarath ... Angeline M Lyon
    Phospholipase Cβ3 is translocated and activated by the heterotrimeric G protein subunit Gαq at the plasma membrane, but the Gβγ heterodimer is required for maximum activation.
    1. Cell Biology
    2. Developmental Biology

    Zinc is a key regulator of the sperm-specific K+ channel (Slo3) function

    Rizki Tsari Andriani, Tanadet Pipatpolkai ... Takafumi Kawai
    Intracellular zinc dynamically changes during sperm capacitation and regulates Slo3-mediated hyperpolarization, while directly inhibiting Slo3 currents through residues contributing to its slow dissociation.
    1. Neuroscience

    Biophysically inspired mean-field model of neuronal populations driven by ion-exchange mechanisms

    Giovanni Rabuffo, Abhirup Bandyopadhyay ... Viktor Jirsa
    Bridging biophysical neuron models with tractable population dynamics opens a route to whole-brain investigation of ion-driven pathological states such as epilepsy and their potential therapeutic targets.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Distal conformational steering by N-terminal pyroglutamylation enables subtype-selective GPCR activation across Aplysia PRXamide and human Neuromedin U signaling

    Jian-Hui Chang, Wei-Jia Liu ... Jian Jing
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    • Incomplete
    1. Neuroscience

    Longitudinal Central Adiposity Accumulation is Associated with Cortical Alteration and Impaired Cognitive Function in Adolescents

    Lingxuan Zhang, Bowen Qiu ... Dan Wu
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Computational and Systems Biology

    A real-time, multi-animal model for automatic face detection and identification of freely moving common marmosets based on YOLOv8 algorithms

    Jiayue Yang, James Wang, Justine Cléry
    A generalizable computational approach automatically identifies individual common marmosets to serve as support for presenting and analyzing behavioral tasks without relying on extensive manual work.
    1. Neuroscience

    Dissociable roles of reward prediction error in the contrasting mood dynamics of depression and anxiety

    Zhihao Wang, Ting Wang ... Pengfei Xu
    Depression-specific symptoms blunt mood responses to unexpected outcomes, whereas anxiety-specific symptoms amplify them in non-clinical participants, with depression-related blunting also replicated in patients with affective disorders.
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