Browse our latest research

Page 2 of 1,882
    1. Neuroscience

    Synaptic connectome of a neurosecretory network in the Drosophila brain

    Theresa H McKim, Jayati Gera ... Meet Zandawala
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Ecology

    Soil extracellular DNA fragments show variable degradation rates among sequences and environmental conditions

    Ting Li, Song Zhang ... Rongxiao Che
    Extracellular DNA degrades at markedly different rates across soils and sequences, substantially biasing estimates of prokaryotic abundance, diversity, and community composition.
    1. Neuroscience

    Differential locus coeruleus–hippocampus interactions during offline states

    Mingyu Yang, Oxana Eschenko
    Noradrenergic tone varies with arousal state, is inversely correlated with hippocampal ripple and sleep spindle oscillations, and differs according to ripple–spindle coupling, with potential implications for synaptic and systems consolidation.
    1. Neuroscience

    Realistic coupling enables flexible macroscopic traveling waves in the mouse cortex

    Guanhua Sun, James Hazelden ... Daniel B Forger
    Multimodal data-driven computational modeling reveals that realistic cortical connectivity can generate more macroscopic traveling waves than local or uniform connectivity in the mouse cortex.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Squidly harnesses enzyme functional hierarchy and contrastive learning to efficiently predict catalytic residues from sequence

    William JF Rieger, Mikael Bodén ... Ariane Mora
    Squidly enables efficient identification of enzyme catalytic residues by integrating functional hierarchies into a contrastive learning framework, requiring only protein sequences to produce scalable predictions across the known enzyme landscape.
    1. Cell Biology

    The insulin/IGF axis is critically important for controlling gene transcription in the podocyte

    Jenny A Hurcombe, Lusyan Dayalan ... Richard JM Coward
    Simultaneously knocking down both the insulin and IGF1 receptor in the kidney podocyte is highly detrimental, affecting spliceosome function and gene transcription.
    1. Neuroscience

    Low-frequency tibial neuromodulation excites bladder activity in humans

    Aidan McConnell-Trevillion, Milad Jabbari ... Kianoush Nazarpour
    Computational modeling and human pilot study present a mechanistic framework explaining the capacity for transcutaneous tibial nerve stimulation to induce excitatory or inhibitory effects based on electrical stimulation frequency alone.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    Ribosomal RNA methylation by GidB modulates discrimination of mischarged tRNA

    Zhuo Bi, Yu-Xiang Chen ... Babak Javid
    The ribosomal rRNA methyltransferase GidB is involved in the discrimination of mischarged tRNAs in mycobacteria.
    1. Immunology and Inflammation

    Bcl11b dose-dependently regulates positive selection of CD8 T cells to the virtual memory fate

    Tom Sidwell, Ellen V Rothenberg
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling