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The C-terminal tail acts as a secondary gate to regulate substrate access into the primary binding site for transport across the membrane.

Dual regulation of TORC1 by Gtr1/2 and Pib2 drives cells into three distinct signaling states, establishing a new paradigm for graded TORC1 signaling.

CHMP5 is crucial in preventing skeletal progenitor cell senescence and abnormal bone formation, and senolytic drugs represent potential therapeutic medicine for musculoskeletal abnormalities associated with a dysfunctional endolysosomal pathway.

Magnetically steered mesenchymal stem cells significantly lowered intraocular pressure for 9 months in mice, motivating the translation of this technology for the treatment of glaucoma.

An analytical approach increases spatiotemporal resolution, optimizes real-time, in vivo detection of Met- and Leu-enkephalin, and provides novel insight into the relationship between Met- and Leu-enkephalin following stress.

Bacterial persistence against phages enables survival under infection, and heat treatment enhances this tolerance, facilitating resistance evolution and influencing the effectiveness of phage therapy.