Browse our latest research

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    1. Structural Biology and Molecular Biophysics

    Binding to nucleosome poises SIRT6 for histone H3 de-acetylation

    Ekaterina Smirnova, Emmanuelle Bignon ... Adam Ben-Shem
    1. Cell Biology

    Metabolic regulation of misfolded protein import into mitochondria

    Yuhao Wang, Linhao Ruan ... Rong Li
    1. Stem Cells and Regenerative Medicine

    Myoglobin-derived iron causes wound enlargement and impaired regeneration in pressure injuries of muscle

    Nurul Jannah Mohamed Nasir, Hans Heemskerk ... Lisa Tucker-Kellogg
    Myoglobin iron contributes to the formation and poor healing of muscle pressure injuries, that is, bedsores, and iron-chelation therapy can be administered after prolonged pressure to increase survival of the damaged tissue.
    1. Microbiology and Infectious Disease

    Phage tRNAs evade tRNA-targeting host defenses through anticodon loop mutations

    Daan F van den Berg, Baltus A van der Steen ... Stan JJ Brouns
    1. Cancer Biology
    2. Computational and Systems Biology

    Comprehensive characterization of tumor microenvironment in colorectal cancer via molecular analysis

    Xiangkun Wu, Hong Yan ... Li Liang
    Integrated molecular analysis demonstrated that colorectal cancer can be classified into four molecular subtypes (proliferative, immunomodulatory, immunosuppressed, and immune-excluded subtypes), providing valuable insight into the intricate relationship between tumor microenvironment heterogeneity and various clinical phenotypes.
    1. Biochemistry and Chemical Biology

    Optical tools for visualizing and controlling human GLP-1 receptor activation with high spatiotemporal resolution

    Loïc Duffet, Elyse T Williams ... Tommaso Patriarchi
    A genetically encoded sensor and a photocaged peptide together enable precise investigation of human glucagon-like peptide-1 receptor activation with high spatiotemporal resolution.
    1. Stem Cells and Regenerative Medicine

    Polycomb repressive complex 1.1 coordinates homeostatic and emergency myelopoiesis

    Yaeko Nakajima-Takagi, Motohiko Oshima ... Atsushi Iwama