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    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Redirection of SARS-CoV-2 to Phagocytes by Intranasal sACE2-Fc as a Universal Decoy Confers Complete Prophylactic Protection

    Jingyi Wang, Jiangchuan Li ... Bo Feng
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Neuroscience

    Reassessing prediction in the brain: Pre-onset neural encoding during natural listening does not reflect pre-activation

    Sahel Azizpour, Britta U Westner ... Linda Geerligs
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Computational and Systems Biology

    Fully computational design of PAM-relaxed Staphylococcus aureus Cas9 with expanded targeting capability using UniDesign

    Youcai Xiong, Li-Kuang Tsai ... Xiaoqiang Huang
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Genetics and Genomics
    2. Neuroscience

    Morphine regulates astrocyte transcriptional dynamics in the ventral tegmental area by stimulation of glucocorticoid signaling

    Jennifer J Tuscher, Angela Cleere ... Jeremy J Day
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Structural Biology and Molecular Biophysics

    Bifunctional Architecture Enables Substrate Catalysis and Channeling in Paracoccus TMAO Demethylase

    Trung Thach, KanagaVijayan Dhanabalan ... Ramaswamy Subramanian
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Incomplete
    1. Ecology

    Full factorial construction of synthetic microbial communities

    Juan Diaz-Colunga, Pablo Catalan ... Alvaro Sanchez
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Compelling
    1. Developmental Biology

    A quantitative in vivo CRISPR-imaging platform identifies regulators of hyperplastic and hypertrophic adipose morphology in zebrafish

    Rebecca Wafer, Panna Tandon, James Minchin
    A scalable zebrafish imaging platform reveals that Foxp1 paralogues have non-redundant roles in developmental patterning of adipose morphology and adaptive remodelling capacity in response to a high-fat diet.
    1. Neuroscience

    Multiple functions of cerebello-thalamic neurons in learning and offline consolidation of a motor skill in mice

    Andrés Pablo Varani, Caroline Mailhes-Hamon ... Daniela Popa
    Distinct cerebellar projections to the forebrain differentially support acquisition and offline consolidation of a motor skill engaging cerebello-striato-cortical circuits, revealing the temporal and functional diversity of cerebellar contributions to learning.
    1. Structural Biology and Molecular Biophysics

    SMC complex unidirectionally translocates DNA by coupling segment capture with an asymmetric kleisin path

    Masataka Yamauchi, Giovanni Bruno Brandani ... Shoji Takada
    An asymmetric kleisin path breaks the symmetry of the SMC homodimer, ensuring unidirectional DNA translocation via a segment capture mechanism.
    1. Cell Biology
    2. Immunology and Inflammation

    Clathrin-independent endocytosis and retrograde transport in cancer cells tune immune synapse organization and CD8 T cell response

    Shiqiang Xu, Alix Buridant ... Henri-François Renard
    Endophilin-A3-mediated clathrin-independent endocytosis and retrograde trafficking in cancer cells regulate ICAM1 organization at the immune synapse and influence cytotoxic CD8 T cell response.
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