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    1. Cell Biology
    2. Neuroscience

    Tau hyperphosphorylation impairs cooperative binding to microtubules and perturbs organelle trafficking in neurons

    Daniel Beaudet, Christopher L Berger, Adam G Hendricks
    Single-molecule motility assays and live-cell imaging in neurons reveal that tau hyperphosphorylation disrupts the formation of cooperative tau envelopes along microtubules and lysosomal transport.
    1. Structural Biology and Molecular Biophysics

    Bifunctional architecture enables substrate catalysis and channeling in Paracoccus TMAO demethylase

    Trung Thach, KanagaVijayan Dhanabalan ... Ramaswamy Subramanian
    Trimethylamine N-oxide demethylase uses substrate channeling to couple trimethylamine N-oxide demethylation with one-carbon metabolism, safely detoxifying formaldehyde while enhancing metabolic efficiency.
    1. Neuroscience

    Selective lifelong suppression of an odor processing channel in response to critical period experience

    Hans C Leier, Julius Jonaitis ... Andrew M Dacks
    Utilizing the olfactory system of Drosophila, a critical period paradigm has provided new insight into the selectivity and longevity of the impact of early life experiences on sensory system circuitry.
    1. Medicine
    2. Neuroscience

    Reverse engineering of motor unit discharge in multiple sclerosis reveals heterogeneity of voluntary motor commands

    Laura M McPherson, Keith R Lohse ... Anne H Cross
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    • Incomplete
    1. Cancer Biology

    IL1β/IL1R1/IRAK4 Drives Inflammatory Ovarian Cancer Seeding at the inflamed sites and Is Reversed by an IRAK4 inhibitor UR241-2

    John P Miller, Kyu Kwang Kim ... Rakesh K Singh
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Cell Biology
    2. Immunology and Inflammation

    Digest before Ingest: Early Recruitment of Membrane-bound DNaseX to Phagocytic Cups in Macrophages

    Arghajit Pyne, Vivek Pandey ... Xuefeng Wang
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Evolutionary Biology

    Evolutionary dynamics of insect odorant receptors reveal ecological tuning shaping olfactory perception

    Tianmin Zhang, Xuanxiao Yang ... Huimeng Lu
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Incomplete
    1. Medicine
    2. Neuroscience

    Synthetic torpor in the rat protects the heart from ischaemia-reperfusion injury

    Megan Elley, Ludovico Taddei ... Michael Ambler
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Cell Biology
    2. Physiology

    Ion channels and GPCR requirements for pressure-induced lymphatic chronotropy: Evidence for a Gαq/11-IP3R1-ANO1 pacemaking axis

    Michael J Davis, Hae Jin Kim ... Scott D Zawieja
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Genetics and Genomics
    2. Ecology

    Decomposition potential and population structure among active microbial communities in deep salt marsh sediments

    Joseph H Vineis, Ashley N Bulseco ... Jennifer L Bowen
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
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