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    1. Biochemistry and Chemical Biology

    Stall force measurement of the kinesin-3 motor KIF1A using a programmable DNA origami nanospring

    Nobumichi Takamatsu, Hiroko Furumoto ... Kumiko Hayashi
    A DNA origami nanospring introduces a force-sensing technology that enables measurement of motor protein stall forces without optical trapping, detecting force changes in kinesin KIF1A and its disease-related mutants.
    1. Cancer Biology
    2. Cell Biology

    Uev1A counteracts oncogenic Ras stimuli in both polyploid and diploid cells

    Qi Zhang, Yunfeng Wang ... Shaowei Zhao
    Uev1A and APC/C degrade CycA to counteract oncogenic Ras, thereby protecting against cell death in polyploid Drosophila nurse cells and suppressing overgrowth in diploid germline and human colorectal tumor cells.
    1. Developmental Biology

    Genetic and physical interactions reveal overlapping and distinct contributions to meiotic double-strand break formation in C. elegans

    Marilina Raices, Fabiola Balmir ... Judith L Yanowitz
    HIM-5 emerges as a central scaffold that coordinates SPO-11 accessory complexes to control different aspects of meiotic DNA double-strand breaks, ensuring robust crossover formation on autosomes and the X chromosome.
    1. Cell Biology

    Orderly mitosis shapes interphase genome architecture

    Krishnendu Guin, Adib Keikhosravi ... Tom Misteli
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Chromosomes and Gene Expression

    Single Domain Antibody Inhibitors Target the Coiled Coil Arms of the Bacillus subtilis SMC complex

    Ophélie Gosselin, Michael Taschner ... Stephan Gruber
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Structural Biology and Molecular Biophysics

    Dynamic Architecture of Mycobacterial Outer Membranes Revealed by All-Atom Simulations

    Turner P Brown, Matthieu Chavent, Wonpil Im
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    The spike tip protein of bacteriophage T4

    Yves Mattenberger, Ekaterina S Knyazhanskaya ... Dominique Belin
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Medicine

    Large-scale synthetic data enable digital twins of human excitable cells

    Pei-Chi Yang, Mao-Tsuen Jeng ... Colleen E Clancy
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Cell Biology

    Engineering ATP Import in Yeast Uncovers a Synthetic Route to Extend Cellular Lifespan

    Naci Oz, Hetian Su ... Alaattin Kaya
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Developmental Biology

    Chromatin priming and Hunchback recruitment integrate spatial and temporal cues in Drosophila neuroblasts

    Ayanthi Bhattacharya, Hemalatha Rao, Sonia Q Sen
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    • Solid
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