The pathogenicity of MECP2 C-terminal deletions is determined by translational reading frame, enabling prediction of clinical outcome and a shared therapeutic genome editing strategy.
Carolyne Jie Huang, Samuel Pawel ... Rachel Heyard
A simulation study shows that metrics suggested to assess replication studies are useful in the translation context, but researchers need to clarify their translation goals a priori.
Separate prefrontal output channels preferentially track anxiety, exploration, and social preference, revealing how emotional context is organized into adaptive behavior.
