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    1. Cell Biology

    SETD6-mediated methylation of PPARγ establishes a transcriptional feedback circuit promoting lipid accumulation in liver-derived cells

    Noa Nashnaz, Dana Goldberg ... Dan Levy
    SETD6-mediated methylation of PPARγ establishes a positive feedback mechanism that enhances transcriptional activation and promotes hepatic lipid accumulation.
    1. Neuroscience

    Noradrenergic infraslow rhythm during sleep is the critical link between heart-rate dynamics and memory consolidation

    Sofie S Jacobsen, Allison B Morehouse ... Celia Kjaerby
    Very-low-frequency heart rate variability reflects locus coeruleus activity during sleep and predicts spindle-dependent memory consolidation across mice and humans.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Pre-Cambrian origin of envelope-carrying retrotransposons in metazoans

    Shashank Chary, Rippei Hayashi
    Envelope-carrying Ty3/gypsy LTR retrotransposons are ancient and widespread across animals, revealing deep evolutionary links between retroelements, viral fusogens, and retroviruses.
    1. Neuroscience

    Dynamic fMRI networks of human emotion

    Niels Janssen, Uriel KA Elvira ... Theo GM van Erp
    Time-resolved mapping of whole-brain functional MRI networks during human emotional experience reveals a dynamic systems-level organization that links temporal processing with large-scale functional brain architecture.
    1. Epidemiology and Global Health

    Understanding pain in women with polyendocrine metabolic ovarian syndrome: health risks and treatment effectiveness

    Tess Cherlin, Stephanie Mohammed ... Shefali Setia Verma
    Pain affects one in five women with PMOS, with pronounced racial disparities and meaningful reduction following targeted medical treatment.
    1. Genetics and Genomics

    Systematic cross-study assessment of RNA-Seq experimental workflows for plasma cell-free transcriptome profiling

    Cristina Tuñí-Domínguez, Giovanni Asole ... Julien Lagarde
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Genetics and Genomics

    Genomic variation and ancestry of Helicobacter pylori in the admixed population of Cabo Verde reveal host adaptation, limited host–pathogen ancestry concordance, and signatures of trans-Atlantic slave trade migrations

    Timothy Archampong, Yi Ling Tam ... Sandra Beleza
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Multi-timescale dynamics organize descending pain modulation

    Carl Ashworth, Melissa Martenson ... Flavia Mancini
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Ecology

    Monkey hear, monkey do what? An application of Automated Behavioural Response systems for hypothesis testing in the world’s smallest monkey

    Larissa Barker, Sarah Papworth
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience

    Prenatal Alcohol Exposure Disrupts γ-Secretase Activity and Impairs Learning and Memory in Wild-Type and 3xTg-AD Mice

    Paola Montenegro, Rachel Kim ... Hermes Yeh
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
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