Browse our latest research

Page 2 of 1,062
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Defining the interactome of the human mitochondrial ribosome identifies SMIM4 and TMEM223 as respiratory chain assembly factors

    Sven Dennerlein et al.
    Definition of the mitoribosome interactome revealed inner membrane proteins and elucidated new assembly factors of the cytochrome c reductase and cytochrome c oxidase.
    1. Microbiology and Infectious Disease

    Reverting the mode of action of the mitochondrial FOF1-ATPase by Legionella pneumophila preserves its replication niche

    Pedro Escoll et al.
    During infection, L. pneumophila reverses the ATP-synthase activity of the mitochondrial FOF1-ATPase to ATP-hydrolase activity in a type 4 secretion-dependent manner to prevent early cell death, thereby preserving its replication niche.
    1. Cell Biology

    V-ATPase V0a1 promotes Weibel–Palade body biogenesis through the regulation of membrane fission

    Yasuo Yamazaki et al.
    A V-ATPase component and protein kinase D are required for the segregation of Weibel–Palade bodies from the trans-Golgi network.
    1. Neuroscience

    Functional independence of endogenous μ- and δ-opioid receptors co-expressed in cholinergic interneurons

    Seksiri Arttamangkul et al.
    Endogenous µ- and δ-opioid receptors do not form stable heterodimers in cholinergic interneurons.
    1. Medicine

    Bisphosphonate drugs have actions in the lung and inhibit the mevalonate pathway in alveolar macrophages

    Marcia A Munoz et al.
    As well as preventing bone loss, bisphosphonate drugs may boost early immune responses in the lung by acting directly on alveolar macrophages that form one of the first lines of defence against infection.
    1. Neuroscience

    Ripples reflect a spectrum of synchronous spiking activity in human anterior temporal lobe

    Ai Phuong S Tong et al.
    A continuum of ripple oscillations in human anterior temporal lobe reflects the dynamic synchrony of populations of neurons during memory retrieval.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Neural control of growth and size in the axolotl limb regenerate

    Kaylee M Wells et al.
    Signaling from the limb nerves regulates the rate of growth and the overall size of the regenerating limb.
    1. Neuroscience

    Presynaptic stochasticity improves energy efficiency and helps alleviate the stability-plasticity dilemma

    Simon Schug et al.
    Presynaptic plasticity in simulated neural networks with a simple biologically plausible learning rule improves metabolic efficiency and lifelong learning capabilities.
    1. Neuroscience

    Convergent, functionally independent signaling by mu and delta opioid receptors in hippocampal parvalbumin interneurons

    Xinyi Jenny He et al.
    Mu and delta opioid receptors signal independently in hippocampal parvalbumin interneurons to regulate somato-dendritic excitability and synaptic transmission, with the delta opioid receptor dominating the response to enkephalin.