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    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Distinguishing different modes of growth using single-cell data

    Prathitha Kar et al.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Molecular architecture of the human tRNA ligase complex

    Alena Kroupova et al.
    1. Biochemistry and Chemical Biology

    A distributed residue network permits conformational binding specificity in a conserved family of actin remodelers

    Theresa Hwang et al.
    A peptide from PCARE achieves >100-fold binding specificity for the EVH1 domain of ENAH, a protein important for metastasis, using a conformational shift mechanism unavailable to ENAH's closely related paralogs VASP and EVL.
    1. Neuroscience

    Silencing long ascending propriospinal neurons after spinal cord injury improves hindlimb stepping in the adult rat

    Courtney T Shepard et al.
    Silencing L2 neurons that project to C6 after a T9 contusion, effectively removing spared axons, results in improved paw placement timing and order, and normalizes speed-dependent changes in swing and stance representing a significant neuroanatomical-functional paradox for spinal cord injury.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Low affinity integrin states have faster ligand binding kinetics than the high affinity state

    Jing Li et al.
    1. Neuroscience

    REST/NRSF drives homeostatic plasticity of inhibitory synapses in a target-dependent fashion

    Cosimo Prestigio et al.
    A combination of electrophysiological, immunocytochemical, and biochemical approaches elucidate the mechanisms by which the transcriptional regulator REST/NRSF rescues neuronal homeostasis by upregulating GABAergic transmission selectively onto excitatory neurons in response to hyperactivity.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    The IRE1/XBP1 signaling axis promotes skeletal muscle regeneration through a cell non-autonomous mechanism

    Anirban Roy et al.
    The IRE1/XBP1 signaling in myofibers is essential for robust skeletal muscle regeneration in response to injury.
    1. Microbiology and Infectious Disease

    A nanocompartment system contributes to defense against oxidative stress in Mycobacterium tuberculosis

    Katie A Lien et al.
    A peroxidase-containing nanocompartment in the bacterial pathogen Mycobacterium tuberculosis protects against oxidative stress and antibiotic treatment in the host.
    1. Neuroscience

    Motor memories of object dynamics are categorically organized

    Evan Cesanek et al.
    The motor-relevant properties of the myriad objects with which we interact on a daily basis are encoded in memory using categorical representations, or 'object families'.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Branched ubiquitin chain binding and deubiquitination by UCH37 facilitate proteasome clearance of stress-induced inclusions

    Aixin Song et al.
    Through interactions with both ubiquitin units that emanate from a branch point in polyubiquitin, UCH37 recognizes and hydrolyzes branched chains to promote proteasome-mediated degradation upon proteolytic stresses.
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