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    1. Neuroscience

    Generative network modeling reveals quantitative definitions of bilateral symmetry exhibited by a whole insect brain connectome

    Benjamin D Pedigo, Mike Powell ... Joshua T Vogelstein
    1. Neuroscience

    Oligodendrocyte-mediated myelin plasticity and its role in neural synchronization

    Sinisa Pajevic, Dietmar Plenz ... R Douglas Fields
    1. Immunology and Inflammation

    A lncRNA identifies Irf8 enhancer element in negative feedback control of dendritic cell differentiation

    Huaming Xu, Zhijian Li ... Martin Zenke
    A novel lncRNA marks the Irf8 downstream enhancer that is crucial for differentiation of plasmacytoid dendritic cells (pDC) and classical dendritic cells type 1 (cDC1) and confers feedback inhibition of Irf8 transcription.
    1. Cell Biology

    Defects in lipid homeostasis reflect the function of TANGO2 in phospholipid and neutral lipid metabolism

    Agustin Leonardo Lujan, Ombretta Foresti ... Vivek Malhotra
    TANGO2 emerges as a key regulator of fatty acid metabolism by likely affecting acyl-CoA production and utilization.
    1. Cell Biology
    2. Cancer Biology

    Transferred mitochondria accumulate reactive oxygen species, promoting proliferation

    Chelsea U Kidwell, Joseph R Casalini ... Minna Roh-Johnson
    Transferred mitochondria do not always regulate cell behavior by simply restoring mitochondrial function, but rather, transferred mitochondria are dysfunctional, initiating downstream signaling and proliferation in response to reactive oxygen species.
    1. Immunology and Inflammation

    Cell circuits between leukemic cells and mesenchymal stem cells block lymphopoiesis by activating lymphotoxin beta receptor signaling

    Xing Feng, Ruifeng Sun ... Joao Pedro Pereira
    Acute lymphoblastic and myeloblastic leukemias activate lymphotoxin beta receptor in mesenchymal stem cells in the bone marrow to turn off interleukin-7 production and lymphopoiesis and gain competitive advantage.
    1. Epidemiology and Global Health

    Associations of ABO and Rhesus D blood groups with phenome-wide disease incidence: A 41-year retrospective cohort study of 482,914 patients

    Peter Bruun-Rasmussen, Morten Hanefeld Dziegiel ... Søren Brunak
    The ABO and RhD blood groups are associated with disease-wide susceptibility differences.
    1. Immunology and Inflammation

    Characterisation of the immune repertoire of a humanised transgenic mouse through immunophenotyping and high-throughput sequencing

    Eve Richardson, Špela Binter ... Simon J Watson
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Polygenic risk scores for the prediction of common cancers in East Asians: A population-based prospective cohort study

    Peh Joo Ho, Iain BeeHuat Tan ... Jingmei Li
    1. Cell Biology
    2. Developmental Biology

    Transcriptional drifts associated with environmental changes in endothelial cells

    Yalda Afshar, Feyiang Ma ... Luisa Iruela-Arispe
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