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    1. Neuroscience

    Spatially targeted inhibitory rhythms differentially affect neuronal integration

    Drew B Headley, Benjamin Latimer ... Satish S Nair
    Beta and gamma inhibitory rhythms are preferentially tuned to govern synaptic integration in layer 5 pyramidal neurons by differentially modulating responses to inputs targeting distal dendritic and perisomatic compartments.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Human-specific lncRNAs contributed critically to human evolution by distinctly regulating gene expression

    Jie Lin, Yujian Wen ... Hao Zhu
    Compared with human-specific transcriptional factors, human-specific lncRNAs identified upon human lncRNAs’ orthologs in mammals have greatly evolved DNA-binding sites in archaic and modern humans in genes determining human traits.
    1. Structural Biology and Molecular Biophysics

    Insights into substrate binding and utilization by hyaluronan synthase

    Zachery Stephens, Julia Karasinska, Jochen Zimmer
    Complementary biochemical and structural findings reveal molecular principles underlying substrate selectivity by a model hyaluronan synthase.
    1. Developmental Biology
    2. Immunology and Inflammation

    HEB collaborates with TCR signaling to upregulate Id3 and enable γδT17 cell maturation in the fetal thymus

    Johanna S Selvaratnam, Juliana Dutra Barbosa da Rocha ... Michele K Anderson
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Reprogramming of host energy metabolism mediated by the TNF-iNOS-HIF-1α axis plays a key role in host resistance to Plasmodium infection

    Kely C Matteucci, Nathalia PS Leite ... Ricardo T Gazzinelli
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Incomplete
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Human adherent cortical organoids in a multiwell format

    Mark van der Kroeg, Sakshi Bansal ... Femke MS de Vrij
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Developmental Biology

    Dual Inhibition of MYRF Cleavage by Its JM Region and PAN-1 CCT Gates Developmental Timing in C. elegans

    Zhimin Xu, Xiaoting Feng ... Yingchuan B Qi
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience

    Principles of Gamma Synchrony Predict Figure–Ground Perception in Texture Stimuli

    Maryam Karimian, Mark J Roberts ... Mario Senden
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Neuroscience

    Audiovisual cues must be predictable and win-paired to drive risky choice

    Brett A Hathaway, Dexter R Kim ... Catharine A Winstanley
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    • Solid
    1. Developmental Biology
    2. Genetics and Genomics

    Ripply1 and Gsc collectively suppress anterior endoderm differentiation from prechordal plate progenitors

    Tao Cheng, Xiang Liu ... Peng-Fei Xu
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Incomplete
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