Browse our latest research

Page 2 of 1,867
    1. Structural Biology and Molecular Biophysics

    In silico design and validation of high-affinity RNA aptamers for SARS-CoV-2 comparable to neutralizing antibodies

    Yanqing Yang, Lulu Qiao ... Ruhong Zhou
    Computer-Aided Aptamer Modeling and Optimization (CAAMO) enables structure-guided RNA aptamer affinity maturation, producing a SARS-CoV-2 RBD (receptor binding domain) binder that rivals neutralizing antibodies and retains predicted activity across variants.
    1. Chromosomes and Gene Expression

    Linking germline telomere removal to global programmed DNA elimination in Tetrahymena genome differentiation

    Kohei Nagao, Alix Lemoine ... Kazufumi Mochizuki
    Tetrahymena germline chromosome ends contain germline-limited sequences that are removed by chromosome breakage, a critical step for programmed DNA elimination of other germline-limited sequences and successful sexual reproduction.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    ATP-driven conformational dynamics reveal hidden intermediates in a heterodimeric ABC transporter

    Matija Pečak, Christoph Nocker, Robert Tampé
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Convincing
    1. Neuroscience

    Sensory adaptation and pupil-linked arousal support flexible evidence accumulation during perceptual decision making

    Kara D McGaughey, Joshua I Gold
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Neuroscience

    Behavioral Signatures of Post-Decisional Attention in Preferential Choice

    Ariel Zylberberg, Ian Krajbich, Michael N Shadlen
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Computational and Systems Biology

    Benchmarking biochemical networks generated by large language models

    Jeevan Tewari, Benjamin W Dahl ... Jeffrey J Saucerman
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience

    Concurrent category-selective neural activity across the ventral occipito-temporal cortex supports a non-hierarchical view of human visual recognition

    Corentin Jacques, Jacques Jonas ... Bruno Rossion
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Biochemistry and Chemical Biology

    A Membrane-Disruptive Action of VBIT-4 Challenges Its Role as a Widely Used VDAC1 Oligomerization Inhibitor

    Varun Ravishankar, Luís Borges-Araújo ... Lucie Bergdoll
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Genetics and Genomics

    Fourfold lifespan extension in C. elegans daf-2 mutant males

    Mike Russell, Michelle Lin ... Liou Y Sun
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Neuroscience

    Relating layer fMRI signals to acoustics and intracranial neuronal activity in the human auditory cortex in a naturalistic design

    Hsin-Ju Lee, Jyrki Ahveninen ... Fa-Hsuan Lin
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
Newer articles Older articles