Browse our latest research

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    1. Immunology and Inflammation

    Macrophages drive inguinal fat pad and lymph node remodelling in response to peripheral inflammation

    Robin Bartolini, Deepika Sharma ... Gerard J Graham
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Neuroscience
    2. Physiology

    Fitness Level, but not Sex, affects Exercise-Induced Pain Modulation

    Janne I Nold, Tahmine Fadai ... Christian Büchel
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Incomplete
    1. Neuroscience

    Striatal dopamine and serotonin release operate largely in parallel with limited, asymmetric crosstalk

    Fabrice Chaudun, Yu Liu ... Christian Lüscher
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    • Convincing
    1. Neuroscience

    Reduced dorsal CA1 activity limits retention of the temporal component of declarative memory in the Cntnap2 knockout mouse model of autism

    Elise Caitlin Rawlinson, Michael Hugh McCullough ... Nathalie Dehorter
    Restoring hippocampal CA1 activation during temporal gaps is sufficient to rescue long-term memory in a mouse model of autism.
    1. Biochemistry and Chemical Biology

    Gluconeogenic compensation renders glycogen phosphorylase non-essential as an insecticidal target in Plutella xylostella

    Yifei Zhou, Yanqi Kang ... Jiyuan Liu
    Gluconeogenesis rescues insects from glycogen phosphorylase suppression, establishing metabolic redundancy as a key consideration for insecticide target selection.
    1. Cell Biology
    2. Immunology and Inflammation

    Allosteric disulfide control of ligand binding and endocytosis of KIR2DL4, the natural killer cell receptor for HLA-G

    Sumati Rajagopalan, Joyce Chiu ... Eric O Long
    Allosteric transition between two disulfide configurations of NK cell receptor KIR2DL4 is a functional switch that controls receptor residence at the cell surface for binding and internalization of soluble HLA-G.
    1. Cancer Biology

    JAK-STAT pathway heterogeneity governs immunotherapy response in breast cancer

    Jianbo Zhou, Heng Zhang ... Fu Peng
    Multi-omics investigation identifies cell-type JAK-STAT heterogeneity as a predictive biomarker for PD-1 blockade in breast cancer.
    1. Physics of Living Systems

    Anatomy and mechanics of tsetse fly blood feeding

    Stephan Löwe, Laura Hauf ... Markus Engstler
    A saw-like proboscis, forceful pulling movements, and precise targeting of softer skin sites allow tsetse flies to draw blood from remarkably diverse vertebrate hosts.
    1. Neuroscience

    Designing optimal perturbation inputs for system identification in neuroscience

    Mikito Ogino, Daiki Sekizawa ... Masafumi Oizumi
    Passive recordings miss patterns of brain activity that fade before they can be observed, but perturbations designed to re-excite those patterns make estimates of neural connections far more accurate.