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    1. Genetics and Genomics

    Identifying in vivo genetic dependencies of melanocyte and melanoma development

    Sarah Perlee, Yilun Ma ... Richard M White
    A zebrafish Cas9 knock-in model enables lineage-specific gene disruption to uncover genetic dependencies in development and disease.
    1. Cancer Biology
    2. Microbiology and Infectious Disease

    The long noncoding RNA lnc-FANCI-2 intrinsically restricts RAS signaling in human papillomavirus type 16-infected cervical cancer cells

    Haibin Liu, Lulu Yu ... Zhi-Ming Zheng
    A newly discovered long noncoding RNA lnc-FANCI-2 suppresses RAS signaling to modulate Akt and Erk1/2 phosphorylation in high-risk HPV cervical cancer, consequently regulating HPV carcinogenesis.
    1. Microbiology and Infectious Disease

    Multi-omics investigation of spontaneous T2DM macaque emphasizes gut microbiota could up-regulate the absorption of excess palmitic acid in the T2DM progression

    Xu Liu, Yuchen Xie ... Jing Li
    Gut dysbiosis and specific microbiota composition promoted the absorption of excess palmitic acid in the ileum, driving its accumulation in the serum.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Thrifty wide-context models of B cell receptor somatic hypermutation

    Kevin Sung, Mackenzie M Johnson ... Frederick A Matsen
    Convolutional embedding models efficiently capture wide sequence context in antibody somatic hypermutation, avoiding exponential k-mer parameter scaling and eliminating the need for per-site modeling.
    1. Neuroscience

    Mesolimbic dopamine ramps reflect environmental timescales

    Joseph R Floeder, Huijeong Jeong ... Vijay Mohan K Namboodiri
    Mesolimbic dopamine ramps emerge only when overall event rates are high, thereby providing a key constraint on theories of dopamine signaling.
    1. Neuroscience

    Blood pressure variability compromises vascular function in middle-aged mice

    Perenkita J Mendiola, Philip O’Herron ... Jessica A Filosa
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Neuroscience

    Virtual Brain Inference (VBI): A flexible and integrative toolkit for efficient probabilistic inference on virtual brain models

    Abolfazl Ziaeemehr, Marmaduke Woodman ... Meysam Hashemi
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Microbiology and Infectious Disease

    The increase in cell volume and nuclear number of the koji-fungus Aspergillus oryzae contributes to its high enzyme productivity

    Ayaka Itani, Haruto Motomura ... Norio Takeshita
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Ecology

    Assessing plant phenological changes based on drivers of spring phenology

    Yong Jiang, Stephen J Mayor ... Qing-Lai Dang
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Neuroscience

    Adult Neurogenesis Reconciles Flexibility and Stability of Olfactory Perceptual Memory

    Bennet Sakelaris, Hermann Riecke
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
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