Browse our latest research

Page 2 of 1,864
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Arrayed single-gene perturbations identify drivers of human anterior neural tube closure

    Roya E Huang, Giridhar M Anand ... Sharad Ramanathan
    A method for arrayed CRISPRi screening in organoids enables the investigation of morphogenesis in human stem cell-derived tissues, revealing the roles of ZIC2, SOX11, and ZNF521 in neural tube closure.
    1. Neuroscience

    Multiple event segmentation mechanisms in the human brain

    Tan T Nguyen, Joset A Etzel ... Jeffrey M Zacks
    The brain uses separate prediction error and prediction uncertainty signals to trigger event boundaries.
    1. Chromosomes and Gene Expression

    Ligand-dependent enhancer activation indirectly modulates non-target promoters in a chromatin domain

    Darshika Bohra, Zubairul Islam ... Dimple Notani
    Ligand-driven enhancer activation selectively boosts target gene expression while indirectly repressing neighboring non-target genes, revealing dynamic and competitive regulation during early transcriptional responses.
    1. Neuroscience

    Development of auditory and spontaneous movement responses to music over the first postnatal year

    Trinh Nguyen, Félix Bigand ... Giacomo Novembre
    Although auditory encoding of music is robust early in infancy, the transformation of this input into movement patterns develops substantially over the first postnatal year, without reaching full maturity.
    1. Chromosomes and Gene Expression

    Impacts of DNA methylation on H2A.Z deposition and nucleosome stability

    Rochelle M Shih, Yasuhiro Arimura ... Hironori Funabiki
    DNA methylation suppresses H2A.Z deposition by inhibiting recruitment of the chaperone SRCAP, while the structural study suggests that methylated DNA can make the H2A.Z nucleosome slightly more accessible.
    1. Ecology

    Coordinated beak–tongue mechanics enable dexterous seed manipulation in songbirds

    Maja Mielke, Falk Mielke ... Sam Van Wassenbergh
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    Rehabilitation drives functional reorganization of intact corticospinal-supraspinal projections following partial spinal cord injury

    James Bonanno, Sheel Trivedi ... William BJ Cafferty
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Cell Biology
    2. Genetics and Genomics

    Cytosolic Carboxypeptidase 5 maintains mammalian ependymal multicilia to ensure proper homeostasis and functions of the brain

    Rubina Dad, Yujuan Wang ... Hui-Yuan Wu
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Rescuing the Function of Missense-Mutated Tumor Suppressor VHL using Stabilizing Small Molecules

    Mariam Ahmed Fouad, Christopher S Parry ... John Karanicolas
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Incomplete
    1. Neuroscience

    Heritability of movie-evoked brain activity and connectivity

    David C Gruskin, Daniel J Vieira ... Gaurav H Patel
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing