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    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Acyl carrier protein is essential for apicoplast biogenesis in malaria parasites independent of fatty acid synthesis

    Sage WR Geher, Seyi Falekun ... Paul A Sigala
    Malaria parasites have evolved a noncanonical function for the apicoplast acyl carrier protein in stabilizing pyruvate kinase II, a metabolic hub essential for isoprenoid synthesis and parasite survival.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Intracellular growth of Chlamydia trachomatis leads to global histone hypermethylation by impairing demethylation

    Chloé I Charendorff, Félix V Louchez ... Agathe Subtil
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    +Clonal stochasticity in early NK cell response to mouse cytomegalovirus is generated by mature subsets of varying proliferative ability

    Darren Wethington, Saeed Ahmad ... Jayajit Das
    Stochastic fluctuations play an important role in the MCMV-induced NK cell clonal expansion that ultimately gives rise to memory NK cells.
    1. Neuroscience

    Auditory cortical feedback signals are modulated during songbird courtship

    Caleb Jones, Jesse H Goldberg
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Zebrafish Rif1 impacts zygotic genome activation, replication timing, and sex determination

    Emily A Masser, Tyler D Noble ... Christopher L Sansam
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Distinct allosteric remodeling of HIV-1 Env dynamics on virions by gp41-directed antibodies reveals two modes of neutralization

    Wang Xu, Narendra Kumar Gonepudi ... Maolin Lu
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience

    Dissociable Roles of Reward Prediction Error in the Contrasting Mood Dynamics of Depression and Anxiety

    Zhihao Wang, Ting Wang ... Pengfei Xu
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Plant Biology
    2. Evolutionary Biology

    Adaptation of an herbivorous arthropod to green tea plants by overcoming catechin defenses

    Naoki Takeda, Brendan Abiskaroon ... Takeshi Suzuki
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology

    Distinct Mechanisms for Inhibition of SARS-CoV-2 Main Protease: Dimerization Promoted by Peptidomimetic Inhibitors and Disrupted by Ebselen

    Chengxi Liu, Qinyu Jia ... Zhong-Ping Yao
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience

    PKD2L1 channels segregated to the apical compartment are the dual-mode pH sensor in cerebrospinal fluid-contacting neurons

    Magdalena Vitar, Daniel Prieto ... Federico F Trigo
    Revised
    Reviewed Preprint v3
    Updated
    • Fundamental
    • Compelling
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