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    1. Neuroscience

    Mapping brain-wide excitatory projectome of primate prefrontal cortex at submicron resolution and comparison with diffusion tractography

    Mingchao Yan et al.
    A comprehensive excitatory projectome of the ventro-lateral prefrontal cortex in macaques was generated by using viral tracing integrated with serial two-photon tomography and diffusion tractography, thus providing new evidence of rejecting the monosynaptic connection of inferior fronto-occipital fasciculus in monkeys.
    1. Neuroscience

    Role of anterior insula cortex in context-induced relapse of nicotine-seeking

    Hussein Ghareh et al.
    The anterior insula cortex is a critical neural substrate of context-induced relapse of nicotine-seeking.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Heterogeneity of the GFP fitness landscape and data-driven protein design

    Louisa Gonzalez Somermeyer et al.
    Orthologous proteins display different mutational robustness that can be leveraged to improve prediction of functional sequences.
    1. Neuroscience

    A discrete parasubthalamic nucleus subpopulation plays a critical role in appetite suppression

    Jessica H Kim et al.
    The hypothalamic parasubthalamic nucleus can be subdivided into two distinct populations, one of which decreases food consumption and is necessary for the full appetite-suppressing effects of anorexigenic hormones.
    1. Cancer Biology
    2. Developmental Biology

    Inflammatory response in hematopoietic stem and progenitor cells triggered by activating SHP2 mutations evokes blood defects

    Maja Solman et al.
    The transcriptomes of hematopoietic stem and progenitor cells of human juvenile myelomonocytic leukemia patients and a zebrafish model for Noonan syndrome reveal a common inflammatory response, which may have a causal role in associated myeloproliferative neoplasm.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Functional and structural segregation of overlapping helices in HIV-1

    Maliheh Safari et al.
    The HIV proteins Env and Rev encode helices that overlap in the viral genome but alternate in functional importance so that the non-functional surface of one helix encodes the functional surface of the other.
    1. Microbiology and Infectious Disease

    Brucella activates the host RIDD pathway to subvert BLOS1-directed immune defense

    Kelsey Michelle Wells et al.
    Brucella facilitates its intracellular parasitism by hijacking the host-regulated IRE1α-dependent decay (RIDD)-BLOS1 innate immune defense system through the disassembly of the BLOC-1-related complex that results in the perinuclear trafficking of Brucella-containing vacuoles and enhanced susceptibility to infection.