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    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Distinct allosteric remodeling of HIV-1 Env dynamics on virions by gp41-directed antibodies reveals two modes of neutralization

    Wang Xu, Narendra Kumar Gonepudi ... Maolin Lu
    Antibodies can target multiple conformational states of the HIV envelope to block viral entry, broadening the mechanisms underlying neutralization.
    1. Microbiology and Infectious Disease

    The type VI secretion system governs strain maintenance in a wild mammalian gut microbiome

    Beth A Shen, Kyle L Asfahl ... Joseph D Mougous
    A type VI secretion system transferred between gut bacteria via a mobile genetic element stabilizes its native host strain, but yields only transient benefits in a new species.
    1. Neuroscience

    Mapping human visual contrast sensitivity and vision loss across the visual field with model-based fMRI

    Hugo T Chow-Wing-Bom, Matteo Lisi ... Tessa M Dekker
    Model‑based fMRI contrast‑sensitivity mapping provides a fixation‑tolerant, large‑field measure of cortical visual function that sensitively detects, localizes, and tracks visual field loss and recovery.
    1. Biochemistry and Chemical Biology

    A Sequential Assembly Mechanism for Stable Cdc13 Dimerization on Telomeric DNA

    Po-Wei Chiu, Yu-Ting Lin ... Jing-Jer Lin
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Structural Biology and Molecular Biophysics
    2. Physics of Living Systems

    Thermodynamic principles of enzymatic regulation in biomolecular condensates from reaction-coupled molecular modeling

    Enrico Lavagna, Francesco Delfino ... Alessandro Barducci
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    From static structures to dynamic landscapes: cryo-EM redefines RNA biology

    Shekhar Jadhav, Spandan Saha ... Marco Marcia
    Not revised
    Reviewed Preprint v1
    1. Neuroscience

    Electroconvulsive stimulation drives cortical spreading depression dependent immediate early gene expression in mice

    Hugo J Ladret, Leonardo Lupori ... Georg B Keller
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Incomplete
    1. Neuroscience

    Zapit: Open Source Laser-Scanning Photostimulation For Neuroscience

    Michael Lohse, Oliver M Gauld ... Robert AA Campbell
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Ecology

    Wetness modulates the effects of grazing on net ecosystem productivity in global grasslands

    Yueqiang Wu, Le Qi ... Biao Zhu
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Genetics and Genomics
    2. Neuroscience

    Transposons contribute to splice-isoform diversity in the Drosophila brain

    Malak Choucri, Tina Rainey, Christoph D Treiber
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
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