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    1. Biochemistry and Chemical Biology

    Isolation of small extracellular vesicles from small volumes of blood plasma using size exclusion chromatography and density gradient ultracentrifugation

    Fang Kong, Megha Upadya ... Ming Dao
    The optimized protocol for isolating small extracellular vesicles from small blood volumes, confirmed by independent methods including cryo-electron microscopy, ensures superior purity and high yield for reliable biomarker detection.
    1. Developmental Biology
    2. Genetics and Genomics

    In situ mutational screening and CRISPR interference define apterous cis-regulatory inputs during compartment boundary formation

    Gustavo Aguilar, Michèle E Sickmann ... Martin Müller
    Early enhancer logic precisely aligns developmental boundaries by integrating HOX, GATA, and signaling inputs, ensuring correct tissue patterning and preventing mirror-image duplications in the developing wing.
    1. Ecology

    Developmental constraints mediate the reversal of temperature effects on the autumn phenology of European beech after the summer solstice

    Dominic Rebindaine, Thomas W Crowther ... Constantin M Zohner
    Faster early-season development, especially under nighttime warming, advances the point at which the autumn phenology of European beech becomes responsive to late-summer cooling.
    1. Neuroscience

    Involuntary feedback responses reflect a representation of partner actions

    Seth R Sullivan, John H Buggeln ... Joshua GA Cashaback
    High-level partner representations tune low-level visuomotor reflexes.
    1. Computational and Systems Biology
    2. Developmental Biology

    A quantitative pipeline for whole-mount deep imaging and analysis of multi-layered organoids across scales

    Alice Gros, Jules Vanaret ... Sham Tlili
    The Tapenade pipeline enables single-cell, whole-mount 3D quantification in dense multilayer organoids, linking spatial gene co-expression and nuclear deformation to emerging tissue-scale organization.
    1. Genetics and Genomics
    2. Neuroscience

    Transcriptional responses to chronic oxidative stress require cholinergic activation of G-protein-coupled receptor signaling

    Kasturi Biswas, Caroline Moore ... Michael M Francis
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Solid
    1. Developmental Biology
    2. Immunology and Inflammation

    Mitochondrial metabolic remodeling drives innate immune activation in Drosophila hemocytes

    Daewon Lee, Ferdinand Koranteng ... Jiwon Shim
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology

    Single-step in vitro ribosome reconstitution mediated by two GTPase factors, EngA and ObgE

    Aya Sato, Weng Yu Lai ... Yoshihiro Shimizu
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Convincing
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Genome reorganization and its functional impact during breast cancer progression

    Kathleen S Metz Reed, Andrew Fritz ... Tom Misteli
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Medicine
    2. Epidemiology and Global Health

    Determining fragility and robustness to missing data in binary outcome meta-analyses, illustrated with conflicting associations between vitamin D and cancer mortality

    David Robert Grimes
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Convincing
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