Browse our latest research

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    1. Cell Biology

    Modular UBE2H-CTLH E2-E3 complexes regulate erythroid maturation

    Dawafuti Sherpa, Judith Mueller ... Arno F Alpi
    Erythroid maturation-dependent remodelling of CTLH E3 complex, along with its cognate E2, controls the orderly progression of human erythropoiesis, thus establishing a paradigm for other E2-E3 ubiquitylation modules involved in developmental processes.
    1. Developmental Biology

    m6A epitranscriptomic modification regulates neural progenitor-to-glial cell transition in the retina

    Yanling Xin, Qinghai He ... Shuyi Chen
    m6A fine-tunes transcriptomic transition from neural progenitors to glial cells in the retina.
    1. Neuroscience

    Uncertainty alters the balance between incremental learning and episodic memory

    Jonathan Nicholas, Nathaniel D Daw, Daphna Shohamy
    1. Cell Biology

    Differential axonal trafficking of Neuropeptide Y-, LAMP1-, and RAB7-tagged organelles in vivo

    Joris P Nassal, Fiona H Murphy ... Matthijs Verhage
    In vivo live imaging reveals the trafficking dynamics of three cellular organelles in neocortical axons with single vesicle resolution and demonstrates activity-dependent changes.
    1. Developmental Biology
    2. Genetics and Genomics

    Lhx2 is a progenitor-intrinsic modulator of Sonic Hedgehog signaling during early retinal neurogenesis

    Xiaodong Li, Patrick J Gordon ... Edward M Levine
    The LIM-homedomain transcription factor Lhx2 confers competence to retinal progenitor cells to activate and maintain Sonic Hedgeghog signaling at physiological levels during a key phase of tissue growth and cell type generation.
    1. Cell Biology
    2. Neuroscience

    Kiaa1024L/Minar2 is essential for hearing by regulating cholesterol distribution in hair bundles

    Ge Gao, Shuyu Guo ... Gang Peng
    Cholesterol plays an essential role in hair bundles, and Kiaa1024L/Minar2 regulates cholesterol distribution and homeostasis to ensure normal hearing.
    1. Neuroscience

    Centrally expressed Cav3.2 T-type calcium channel is critical for the initiation and maintenance of neuropathic pain

    Sophie L Fayad, Guillaume Ourties ... Nathalie Leresche
    Specific deletion of Cav3.2 channels in anterior pretectal neurons reduced mechanical and cold allodynia, pointing to Cav3.2 channels as prime targets to develop innovative analgesic pharmacology that will not only act at the peripheral level but also in central structures.
    1. Structural Biology and Molecular Biophysics

    A cryogenic, coincident fluorescence, electron, and ion beam microscope

    Daan B Boltje, Jacob P Hoogenboom ... Sander den Hoedt
    Integrating a cryogenic light microscope with a focused ion beam/scanning electron microscope, allows directly targeting of fluorescent structure when preparing a frozen-hydrated lamella, without the need for repositioning or fiducial markers.
    1. Developmental Biology

    Amino acid transporter SLC38A5 regulates developmental and pathological retinal angiogenesis

    Zhongxiao Wang, Felix Yemanyi ... Jing Chen
    Experimental analysis of SLC38A5 (solute carrier family 38 member 5) in mouse models and cell culture reveals its novel role as a metabolic regulator of retinal angiogenesis by controlling nutrient uptake and homeostasis in blood vessel endothelium.