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    1. Structural Biology and Molecular Biophysics

    Single-Molecule Nanopore Profiling of p53-TAD’s Conformational Dynamics, Interactions, and Inhibition

    David DeCoeur, Samantha Schultz ... Min Chen
    Not revised
    Reviewed Preprint v1
    • Useful
    • Compelling
    • Incomplete
    1. Cell Biology
    2. Developmental Biology

    Dynamin 2–dependent endocytosis differentially regulates ligand and receptor contributions to Notch signaling during neural precursor cell fate determination

    Joshua J Breunig, Jon I Arellano ... Pasko Rakic
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Chromosomes and Gene Expression

    KMT2A modulates the epigenetic landscape of rDNA by facilitating the recruitment of histone lysine acetyltransferase PCAF to the rDNA locus

    Kaisar Ahmad Lone, Anita Choudhary ... Shweta Tyagi
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Cell Biology

    Integrin-dependent trafficking of CD98hc reduces endocytic noise to maintain metabolic homeostasis

    F Sila Rizalar, Hans Peter Grimm ... Roberto Villaseñor
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    • Incomplete
    1. Microbiology and Infectious Disease
    2. Computational and Systems Biology

    High-dimensional Characterization of Genome–Environment Fitness Landscapes in Klebsiella pneumoniae

    Ge Zhou, Georgia Williams ... Danesh Moradigaravand
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Genetics and Genomics
    2. Plant Biology

    Multi-omic integration using interpretable machine learning reveals genetic mechanisms of trait variation and phenotypic plasticity in switchgrass

    Paulo Izquierdo, Xiaoyu Weng ... Shin-Han Shiu
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Neuroscience

    Simple methods to acutely measure multiple timing metrics among the sexual repertoire of male Drosophila

    Yutong Song, Hongyu Miao ... Woo Jae Kim
    DrosoMating is a streamlined software and open-hardware platform that automates high-throughput temporal profiling of male Drosophila courtship and mating behaviors with high accuracy.
    1. Neuroscience

    Expectation-driven gain modulation of preparatory spatial attention

    Dirk van Moorselaar, Stefan van der Stigchel
    Expectations about visual search difficulty enhance processing at attended locations by strengthening attentional signals rather than narrowing the spatial focus of attention.
    1. Genetics and Genomics
    2. Neuroscience

    The hypoxic response extends lifespan through a bioaminergic and peptidergic neural circuit

    Elizabeth S Kitto, Shijiao Huang ... Scott F Leiser
    Genetic induction of the hypoxic response promotes longevity through a cell-nonautonomous neuronal to intestinal circuit governed by serotonin, tyramine/adrenaline, GABA, and neuropeptide signaling.
    1. Neuroscience

    The resource elasticity of control

    Levi Solomyak, Aviv Emanuel, Eran Eldar
    People effectively estimate how much their control is dependent on the resources they are willing or able to invest, whereas misjudging this relationship is linked to maladaptive behavior and psychopathology.
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