Browse our latest research

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    1. Microbiology and Infectious Disease

    Tools and methods for high-throughput single-cell imaging with the mother machine

    Ryan Thiermann, Michael Sandler ... Suckjoon Jun
    1. Medicine

    Hammerhead-type FXR agonists induce an eRNA FincoR that ameliorates nonalcoholic steatohepatitis in mice

    Jinjing Chen, Ruoyu Wang ... Jongsook Kim Kemper
    1. Developmental Biology
    2. Neuroscience

    Pleiotropic effects of trisomy and pharmacologic modulation on structural, functional, molecular, and genetic systems in a Down syndrome mouse model

    Sergi Llambrich, Birger Tielemans ... Greetje Vande Velde
    Ts65dn mice exhibit structural, functional, molecular, and genetic alterations that are modulated but unrecovered by prenatal chronic GTE-EGCG, highlighting the importance of holistic studies to understand complex disorders and treatments.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Dynamic 1D search and processive nucleosome translocations by RSC and ISW2 chromatin remodelers

    Jee Min Kim, Claudia C Carcamo ... Carl Wu
    Single-particle imaging of RSC and ISW2 chromatin remodelers on DNA stretched between dual optical tweezers reveals distinctive 1D diffusion and opposing push–pull nucleosome translocation on engagement with sparse nucleosome arrays.
    1. Immunology and Inflammation

    Single-cell RNA sequencing unveils the hidden powers of zebrafish kidney for generating both hematopoiesis and adaptive antiviral immunity

    Chongbin Hu, Nan Zhang ... Jian-zhong Shao
    scRNA-seq revealed the fish kidney is a dual-functional entity with functionalities of both primary and secondary lymphoid organs and highlighted the multifaced biology of kidney in ancient vertebrates.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Transformer-based spatial–temporal detection of apoptotic cell death in live-cell imaging

    Alain Pulfer, Diego Ulisse Pizzagalli ... Santiago Fernandez Gonzalez
    ADeS, a novel deep learning approach for apoptosis detection, achieves 98% accuracy in vitro and in vivo while providing unprecedented insights into the spatial–temporal foundation of cell death.
    1. Ecology

    Habitat loss weakens the positive relationship between grassland plant richness and above-ground biomass

    Yongzhi Yan, Scott Jarvie, Qing Zhang
    Habitat loss rather than fragmentation per se can weaken the positive BEF relationship by reducing the percentage of grassland specialists in the community.
    1. Evolutionary Biology
    2. Immunology and Inflammation

    Caspase-1 activates gasdermin A in non-mammals

    Zachary Paul Billman, Stephen Bela Kovacs ... Edward A Miao
    Amphibians, reptiles, and birds engage pyroptosis using caspase-1 and GSDMA, filling an evolutionary gap in which caspase-1 cleaves GSDME in fish and GSDMD in mammals.
    1. Structural Biology and Molecular Biophysics

    Structural dynamics of the active HER4 and HER2/HER4 complexes is finely tuned by different growth factors and glycosylation

    Raphael Trenker, Devan Diwanji ... Natalia Jura
    Cryo-EM structures uncover glycosylation in the ectodomains of full-length HER4 homodimer and HER2/HER4 heterodimer complexes, revealing how the binding of various growth factors alters dynamics at the dimerization interface.
    1. Computational and Systems Biology

    Metabolic model-based ecological modeling for probiotic design

    James D Brunner, Nicholas Chia
    Genome-scale metabolic models can be used to predict the engraftment of probiotics.