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Page 316 of 1,785
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Signatures of transposon-mediated genome inflation, host specialization, and photoentrainment in Entomophthora muscae and allied entomophthoralean fungi

    Jason E Stajich, Brian Lovett ... Carolyn Elya
    Entomophthora muscae has one of the largest fungal genomes (1.03 Gb) owing to extensive proliferation of transposable elements.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Epistasis facilitates functional evolution in an ancient transcription factor

    Brian PH Metzger, Yeonwoo Park ... Joseph W Thornton
    A complete mutational scan of a protein-DNA interface shows that pairwise epistatic interactions among amino acids determine a transcription factor's specificity for DNA and facilitate the evolution of new functions.
    1. Neuroscience

    Single-cell RNA sequencing of iPSC-derived brain organoids reveals Treponema pallidum infection inhibiting neurodevelopment

    Qiu-Yan Xu, Yong-Jing Wang ... Tian-Ci Yang
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Dietary bacteria control C. elegans fat content through pathways converging at phosphatidylcholine

    Hsiao-Fen Han, Shao-Fu Nien ... Yi-Chun Wu
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Neuroscience

    FMRP regulates postnatal neuronal migration via MAP1B

    Salima Messaoudi, Ada Allam ... Isabelle Caille
    A novel neurodevelopmental role for FMRP in collaboration with MAP1B, jointly orchestrating neuronal migration by influencing the microtubular cytoskeleton.
    1. Cell Biology

    PI3K/HSCB axis facilitates FOG1 nuclear translocation to promote erythropoiesis and megakaryopoiesis

    Gang Liu, Yunxuan Hou ... Xiumei Jiang
    HSCB could be activated by PI3K signaling to facilitate FOG1 nuclear translocation to promote human erythropoiesis and megakaryopoiesis, highlighting an important, previously unrecognized iron–sulfur cluster delivery independent function of HSCB.
    1. Stem Cells and Regenerative Medicine

    Long-term hematopoietic transfer of the anti-cancer and lifespan-extending capabilities of a genetically engineered blood system by transplantation of bone marrow mononuclear cells

    Jing-Ping Wang, Chun-Hao Hung ... C-K James Shen
    The anti-cancer or lifespan extension properties of a novel genetically engineered hematopoietic blood system could be transferred horizontally in mice, which suggests a new direction of biomedical research for anti-aging/antidisease.
    1. Ecology
    2. Epidemiology and Global Health

    Landscape drives zoonotic malaria prevalence in non-human primates

    Emilia Johnson, Reuben Sunil Kumar Sharma ... Kimberly Fornace
    Regional meta-analysis enriches our understanding of zoonotic malaria in primate reservoirs in areas of Southeast Asia experiencing deforestation, with wider ecological implications for human disease risk in fragmented landscapes.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Remodeling of skeletal muscle myosin metabolic states in hibernating mammals

    Christopher TA Lewis, Elise G Melhedegaard ... Julien Ochala
    During hibernation, animals remodel the structure of their relaxed muscle via a protein called myosin and this enables vast temperature changes.
    1. Epidemiology and Global Health

    Misstatements, misperceptions, and mistakes in controlling for covariates in observational research

    Xiaoxin Yu, Roger S Zoh ... David B Allison
    This quick reference guide for researchers addresses common misconceptions in the use of covariates in observational research and offers tips for preventing misstatements and mistakes.