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    1. Evolutionary Biology
    2. Genetics and Genomics

    Gene expression plasticity followed by genetic change during colonization in a high-elevation environment

    Huishang She, Yan Hao ... Yanhua Qu
    An integrative approach allows investigations of the relationship between an initial plasticity and the subsequent adaptive evolution during rapid adaptive modification of complex systems in the wild.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The catalytic mechanism of the RNA methyltransferase METTL3

    Ivan Corbeski, Pablo Andrés Vargas-Rosales ... Amedeo Caflisch
    A multidisciplinary study reveals the reaction mechanism and transition state of adenosine-N6 methyl transfer catalyzed by human METTL3-14, deepening our insight into RNA methyltransferases and paving the way for similar studies on related enzymes.
    1. Developmental Biology

    FBXO24 modulates mRNA alternative splicing and MIWI degradation and is required for normal sperm formation and male fertility

    Zhiming Li, Xingping Liu ... Shuiqiao Yuan
    Animal models and molecular data reveal how FBXO24 regulates mRNA expression and MIWI degradation in the round spermatids.
    1. Cell Biology
    2. Developmental Biology

    Perirenal adipose tissue contains a subpopulation of cold-inducible adipocytes derived from brown-to-white conversion

    Houyu Zhang, Yan Li ... Meng Xie
    A brown-to-white adipogenic transdifferentiation process in the periureter region of mouse renal adipose tissue gives rise to a population of cold-inducible adipocytes with a transcriptome distinct from subcutaneous beige adipocytes.
    1. Neuroscience

    Coordinated head direction representations in mouse anterodorsal thalamic nucleus and retrosplenial cortex

    Marie-Sophie H van der Goes, Jakob Voigts ... Mark T Harnett
    Dual site recordings of mouse anterodorsal thalamic nucleus and retrosplenial cortex reveal near 0-ms lag between the head direction representations of the two regions after cue rotations and correlated drift in darkness.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Random genetic drift sets an upper limit on mRNA splicing accuracy in metazoans

    Florian Bénitière, Anamaria Necsulea, Laurent Duret
    Variation in the rate of alternative splicing across animals are mainly driven by differences in the rate of splicing errors.
    1. Neuroscience

    Combinatorial expression of γ-protocadherins regulates synaptic connectivity in the mouse neocortex

    Yi-jun Zhu, Cai-yun Deng ... Hua-tai Xu
    For neurons to prevent undesirable synaptic connections in the brain, the combinatorial expression of γ-PCDH is essential.
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    1. Neuroscience

    Neural attentional filters and behavioural outcome follow independent individual trajectories over the adult lifespan

    Sarah Tune, Jonas Obleser
    Individual listening behaviour and neural filtering ability follow independent developmental trajectories in a large, N = 105, cohort of ageing individuals.
    1. Neuroscience
    2. Physics of Living Systems

    Neural criticality from effective latent variables

    Mia C Morrell, Ilya Nemenman, Audrey Sederberg
    Signatures of criticality that have been observed across diverse neural systems, such as power-law avalanche distributions and exponent relationships, can arise without fine-tuning in networks coupled to latent, dynamical variables.