Browse our latest research

Changing substituents on the aromatic rings of polyunsaturated fatty acid analogues tailors their activation effect on the I_Ks channel and thus their therapeutic potential for long QT syndrome.

A road to modulators of the kinase activity and the non-enzymatic functions of Src and IDO1 at once.

Two flying squirrel species chewed grooves into Cyclobalanopsis nuts, and used them to pressure-fit nuts tightly in crotches formed by small twigs on understory plants, in a way similar to a mortise-tenon joint used in architecture and carpentry.

Regulation of phosphoinositide 3 kinase (PI3Kγ) is essential in immune function, and stimuli that modulate the dynamics of the PI3Kγ helical domain can activate or inhibit kinase activity.

Linguistic features are encoded more strongly during language comprehension than when comprehension is absent, and high word entropy (less constraining context) enhances the encoding of lower-level acoustic and linguistic features while low word entropy suppresses it.

The dietary vitamin riboflavin provides the chemical backbone to generate essential substrates that support liver glucose metabolism during low-nutrient conditions.

Manipulating cell death in situ with the temporal and spatial precision of optogenetic tools opens up new avenues for studying inflammation, death and related phenomena, revealing, for example, that epithelial cell death cannot be classified into strictly distinct categories.

Two-photon microscopy, combined with chemotaxis assays, synchronized thymocyte selection studies, and flow cytometry analyses, reveal that CCR4 and CCR7 promote medullary entry and central tolerance of immature and mature post-positive selection thymocyte subsets, respectively, with distinct outcomes for central tolerance.

MS-Hu6 biotherapeutic formulation for the treatment of osteoporosis, obesity, and Alzheimer's disease.

The endoplasmic reticulum (ER) folding sensor UGGT1 essentially cooperates with the peptide editor TAPBPR to provide quality control of MHC I molecules in the antigen presentation pathway.