Efficiency measures the fundamental link between agonist binding and protein conformational change, and in nicotinic receptors has 5 values that calibrate energy changes in the induced fit that triggers activation.
Close friend quantity is nonlinearly associated with various mental health and cognitive outcomes in children and could be partly explained by the structure of the social brain and the endogenous opioid system.
Local disinhibition provides a biologically plausible mechanism for flexible top-down control of network states that integrates normalized value coding, winner-take-all choice, and persistent activity in a single circuit of decision-making.
Ribosomal proteins Rps27 (eS27) and Rps27l (eS27L) are an ancient pair of duplicated genes that encode functionally interchangeable proteins, yet have been evolutionarily retained because both copies are necessary to achieve protein expression across cell types.
David J Ottenheimer, Madelyn M Hjort ... Garret D Stuber
Individual neurons in a surprising number of frontal cortical regions encode the value of reward-predicting olfactory cues across distinct stimulus sets and experimental sessions.
Ellen M Acosta, Katherine A Little ... Zemer Gitai
The bacterial DNA on the surface of human and mouse skin is primarily from dead bacteria while viable skin microbiome bacteria mostly colonize subsurface skin structures like hair follicles.
A 'stimulus-computable' modeling approach resolves apparent inconsistencies between human and monkey lesion data, implicating perirhinal cortex in visual object perception.
Many published findings about population history that rely on inference of admixture graph models fitted to f-statistics are not robust since the method is generally inappropriate for extracting new information about population history.
Jamie D Costabile, Kaarthik A Balakrishnan ... Martin Haesemeyer
Model identification of neural encoding is an accessible system for the analysis of neural data that allows identifying and characterizing arbitrary relationships between neural activity and task-related variables such as behavior, stimuli, or internal states.
