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Prolonged CD4⁺ and CD8⁺ T-cell activation and long COVID symptoms at 3 months post hospitlization independently associate with severe COVID-19, and ongoing T-cell activation does not affect the generation and maintenance of memory T-cell and antibody responses to SARS-CoV-2.

Cerebral subcortical microcirculation is more vulnerable to aging-induced changes and more responsive to exercise than cortical microcirculation.

TARDIS enables efficient and diverse transgenesis in Caenorhabditis elegans by integrating synthetic DNA libraries into engineered genomic sites, rivaling the scale of transformation previously only possible in microbes.

P4-ATPase BbCrpa detoxifies secondary metabolites via a unique vesicle-mediated transport pathway that targets the compounds into vacuoles.

A framework has been devised that enables global participation in the curation of publications on any topic involving two or more living organisms, ranging from microscopic to larger sizes, in their natural or artificial environments or ecosystems.

The transition of Staphylococcus aureus from commensalism to invasive disease, bacteraemia, is a complex balancing act offsetting offensive and defensive virulence strategies involving the Tca cell wall stress stimulon locus.

The HCN1 channel gates thanks to a coupling mechanism involving the reorganization of the interfaces between the voltage-sensor domains and pore helices, subtly shifting the balance between hydrophobic and hydrophilic interactions in a 'domino effect'.

Enhancing the management of Gaucher disease patients through multidimensional risk assessment serves as a roadmap towards personalized medicine in the context of a rare disease.

Opioids have distributed effects on the brainstem circuitry that controls breathing, including presynaptic and postsynaptic receptor-mediated inhibition of an excitatory circuit from the dorsolateral pons to the ventrolateral medulla.