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A mutation in the lineage-determining regulator C/EBPα that increases the factor’s affinity for its partner PU.1 dramatically accelerates the velocity of B cell to macrophage transdifferentiation.

Loss of the extracellular matrix protein Perlecan leads to disruption of the neural lamella surrounding nerve bundles in Drosophila, resulting in axonal breakage and synaptic retraction of neuromuscular junctions.

Insight into the activity of β-heavy spectrin is provided by the discovery that it can compete with myosin for association with F-actin, which provides explanations for its influences on Hippo signaling and morphogenesis.

Using unique data from five longitudinal UK birth cohorts, four distinct subsets of genetic variants were identified as differentially associated across wheezing phenotypes from infancy to adolescence with little evidence of genetic associations spanning across different phenotypes.

The synergy between aging and injury impairs alveolar progenitor functions leading to progressive lung fibrosis.

In baboon gut microbiota, most pairwise correlations in bacterial abundances are weak and negative, and bacterial correlation patterns are largely shared across hosts, rather than personalized to each hosts.

Optogenetics was used to reveal a novel role for the perirhinal cortex in regulating approach-avoidance behaviors under object-based motivational conflict.

Activating deeper layers of the cortex using cortical electrical stimulation triggers the activation of thalamic nuclei through trans-synaptic signaling, which can result in a range of complex responses that can be detected using EEG signals.

Phylogenetic analyses of the four core virion proteins support a new evolutionary model for the origin of the main groups of eukaryotic viruses in the kingdom Bamfordvirae.