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    1. Cell Biology
    2. Developmental Biology

    Differential modification of the C-terminal tails of different α-tubulins and their importance for microtubule function in vivo

    Mengjing Bao, Ruth E Dörig ... Beat Suter
    Specific glutamylation of some α-tubulin isotypes affects kinesin-1 localization and transport processes that depend on it, but their absence can speed up transport, possibly explaining why some large cells express α-tubulin isotypes that are not glutamylated.
    1. Epidemiology and Global Health

    Perceived barriers to cervical cancer screening and motivators for at-home human papillomavirus self-sampling during the COVID-19 pandemic: Results from a telephone survey

    Susan Parker, Ashish A Deshmukh ... Jane R Montealegre
    Mailed at-home HPV self-sampling kits present an opportunity to reduce important barriers to cervical cancer screening among women in a safety net healthcare system.
    1. Ecology

    Temperature sensitivity of the interspecific interaction strength of coastal marine fish communities

    Masayuki Ushio, Testuya Sado ... Masaki Miya
    Fish environmental DNA remaining in a cup of seawater provides information about interaction strengths among marine fish species in nature, highlighting the potential impact of global climate change on community dynamics and stability.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    A novel single alpha-helix DNA-binding domain in CAF-1 promotes gene silencing and DNA damage survival through tetrasome-length DNA selectivity and spacer function

    Ruben Rosas, Rhiannon R Aguilar ... Mair EA Churchill
    The lysine/glutamic acid/arginine region in chromatin assembly factor (CAF-1) forms a long single alpha-helix DNA-binding domain, facilitating the recognition of tetrasome-length DNA and linking functional domains within the CAF-1 architecture for efficient tetrasome assembly after DNA synthesis.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    SNORD90 induces glutamatergic signaling following treatment with monoaminergic antidepressants

    Rixing Lin, Aron Kos ... Gustavo Turecki
    A small non-coding RNA, SNORD90, links monoaminergic directed antidepressant treatment with glutamatergic activation.
    1. Neuroscience

    Dopamine signaling regulates predator-driven changes in Caenorhabditis elegans’ egg laying behavior

    Amy Pribadi, Michael A Rieger ... Sreekanth H Chalasani
    Caenorhabditis elegans responds to predator threat by using dopamine signaling to alter the distribution of their eggs.
    1. Neuroscience

    Sharing neurophysiology data from the Allen Brain Observatory

    Saskia EJ de Vries, Joshua H Siegle, Christof Koch
    A growing community demand for open neurophysiology data calls for new standards and tools to help scientists share data from their experiments, find relevant datasets that others have collected, and track data reuse across the literature.
    1. Neuroscience

    Target cell-specific synaptic dynamics of excitatory to inhibitory neuron connections in supragranular layers of human neocortex

    Mean-Hwan Kim, Cristina Radaelli ... Ed Lein
    Electrophysiological study in human brain slices reveals that short-term synaptic plasticity from presynaptic pyramidal neuron to postsynaptic interneuron connections are target-cell specific based on their subclass interneuron identity.
    1. Neuroscience

    Flexible specificity of memory in Drosophila depends on a comparison between choices

    Mehrab N Modi, Adithya E Rajagopalan ... Glenn C Turner
    Flies can optimally recall a memory with high specificity by comparing options close in time, or default to generalization when they cannot.
    1. Cell Biology
    2. Computational and Systems Biology

    From actin waves to mechanism and back: How theory aids biological understanding

    Carsten Beta, Leah Edelstein-Keshet ... Arik Yochelis
    Mathematical methods reveal common underlying principles in diverse models of intracellular actin waves.