HOTAIR is required in an ongoing manner when it regulates epigenetic status and reprograms cancer cell gene expression in promoting breast cancer metastasis.
Luca Costantino, Stefania Ferrari ... Maria Paola Costi
The dimer destabilizers cause a dimer-to-monomer equilibrium shift favoring the human thymidylate synthase monomer more degradable by the proteasome, thus breaking the long-standing link between inhibition and enhanced expression of the protein to fight cancer drug resistance.
Molecular timekeeping in Neurospora crassa is robust even under severe limitation of carbon sources and the efficient adaptation to changing nutrient availability is dependent on the positive component of the circadian clock.
Immunization with NY-ESO-1 S-FLU virus elicits a robust NY-ESO-1-specific CTL response and suppresses the NY-ESO-1-expressing tumour development and spontaneous metastasis.
Joseph M Replogle, Jessica L Bonnar ... Marco Jost
Newly developed, highly active CRISPR interference single guide RNA libraries and effectors together enable high-quality genetic screens across cell models.
scatterHatch helps users generate colorblind-friendly scatter plot visualizations by using a combination of patterns and high-contrast colors to represent distinct point groups.
Single-cell analysis of injured mouse sciatic nerves reveals rapid reprogramming of macrophages toward a glycolytic, proinflammatory phenotype during the early repair process.
Éléonore Duvelle, Roddy M Grieves, Matthijs AA van der Meer
A synthesis of 20+ years of experimental studies on 'splitter cells' in the hippocampus reveals that signature properties of (1) temporal context models and (2) latent state inference are both needed to account for the data.
