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The lymphatic and blood network of the mouse epididymis in adulthood and during postnatal ontogeny has been analyzed in detail.

Descending inhibition of nociception from the brain has been identified in Drosophila larvae, for the first time in non-mammalian organisms.

Consistent bimodal variations in the femoral morphology of various modern amniotes and a remarkably large herd of coeval fossil non-avian theropods evidences sexual dimorphism in dinosaurs.

In awake behaving rats, cholinergic interneurons in the nucleus accumbens drive dopamine release via nicotinic receptors, boosting motivation to work.

Experimentation on patient biopsies, cell culture, and xenograft models demonstrates involvement of ErbB signaling and fibroblasts in lesion growth, implying that targeting of both stromal and endothelial cells could be a beneficial treatment strategy for patients with venous lesions.

Analysis of the tumor microenvironment reveals that pancreatic tumors experience metabolic stress caused by immune cell degradation of the amino acid arginine, and that pancreatic cancers cope by synthesizing arginine to provide access this amino acid despite low tumor availability.

Deletion of Arginase 1 in myeloid cells delays tumor formation in pancreatic cancer.

A combination of in vivo and in vitro approaches using Xenopus eggs and embryos reveals how dimensions of mitotic chromosomes scale with decreasing cell size and increasing nuclear-cytoplasmic ratio during early embryogenesis.

Transcriptional activation of the orphan nuclear receptor Nurr1 by ligands targeting its heterodimer partner retinoid X receptor alpha (RXRα) occurs through a nonclassical pharmacological mechanism involving ligand-binding domain protein-protein interaction inhibition.