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Page 516 of 1,838
    1. Structural Biology and Molecular Biophysics

    The prolactin receptor scaffolds Janus kinase 2 via co-structure formation with phosphoinositide-4,5-bisphosphate

    Raul Araya-Secchi, Katrine Bugge ... Birthe B Kragelund
    The prolactin receptor, Janus kinase 2, and PI(4,5)P2 form a co-structure with the membrane resulting in orientations with different accessibility fixing the disordered juxtamembrane domain of the receptor in an extended structure.
    1. Neuroscience

    Prolonged nicotine exposure reduces aversion to the drug in mice by altering nicotinic transmission in the interpeduncular nucleus

    Sarah Mondoloni, Claire Nguyen ... Alexandre Mourot
    Inter-individual variabilities in nicotine aversion are linked with responses of the interpeduncular nucleus to the drug.
    1. Neuroscience

    Are single-peaked tuning curves tuned for speed rather than accuracy?

    Movitz Lenninger, Mikael Skoglund ... Arvind Kumar
    Single-peaked tuning curves found in early sensory areas are more optimized for quick decoding than accuracy, while multi-peaked tuning curves (e.g. grid cells) give higher accuracy but only at longer time scales.
    1. Genetics and Genomics
    2. Neuroscience

    Tau polarizes an aging transcriptional signature to excitatory neurons and glia

    Timothy Wu, Jennifer M Deger ... Joshua M Shulman
    While tau and aging have highly overlapping differential gene expression signatures, they diverge in the affected cell types, with aging having a wide-ranging impact and tau-triggered changes instead polarized to excitatory neurons and glia.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Substrate stiffness impacts early biofilm formation by modulating Pseudomonas aeruginosa twitching motility

    Sofia Gomez, Lionel Bureau ... Sigolene Lecuyer
    The spatial organization of pathogenic bacteria into microcolonies can be shaped by the stiffness of the substrate that they colonize, via modifications of the bacterial motility.
    1. Cell Biology

    Global analysis of contact-dependent human-to-mouse intercellular mRNA and lncRNA transfer in cell culture

    Sandipan Dasgupta, Daniella Y Dayagi ... Jeffrey E Gerst
    The RNA transferome comprises full-length mRNAs and lncRNAs that undergo non-selective and expression-dependent transfer between mammalian cells in culture via actin-based tunneling nanotubes.
    1. Cell Biology
    2. Neuroscience

    Repair of noise-induced damage to stereocilia F-actin cores is facilitated by XIRP2 and its novel mechanosensor domain

    Elizabeth L Wagner, Jun-Sub Im ... Jung-Bum Shin
    A novel mechanism for F-actin repair is involved in the maintenance of sensory hair cells and hearing function.
    1. Epidemiology and Global Health

    Changes in transmission of Enterovirus D68 (EV-D68) in England inferred from seroprevalence data

    Margarita Pons-Salort, Ben Lambert ... Nicholas C Grassly
    Serocatalytic models applied to seroprevalence data from England reveal an increase in Enterovirus D68 transmission that occurred before 2011.
    1. Microbiology and Infectious Disease

    Homeostatic control of an iron repressor in a GI tract resident

    Yuanyuan Wang, Yinhe Mao ... Changbin Chen
    Post-translational modifications of an iron-responsive regulator drive Candida albicans commensalism in gastrointestinal tract.
    1. Structural Biology and Molecular Biophysics

    Robust membrane protein tweezers reveal the folding speed limit of helical membrane proteins

    Seoyoon Kim, Daehyo Lee ... Duyoung Min
    An exceedingly low speed limit was estimated for a helical hairpin formation by analyzing hours-long, incessant structural transitions.