Raul Araya-Secchi, Katrine Bugge ... Birthe B Kragelund
The prolactin receptor, Janus kinase 2, and PI(4,5)P2 form a co-structure with the membrane resulting in orientations with different accessibility fixing the disordered juxtamembrane domain of the receptor in an extended structure.
Movitz Lenninger, Mikael Skoglund ... Arvind Kumar
Single-peaked tuning curves found in early sensory areas are more optimized for quick decoding than accuracy, while multi-peaked tuning curves (e.g. grid cells) give higher accuracy but only at longer time scales.
While tau and aging have highly overlapping differential gene expression signatures, they diverge in the affected cell types, with aging having a wide-ranging impact and tau-triggered changes instead polarized to excitatory neurons and glia.
The spatial organization of pathogenic bacteria into microcolonies can be shaped by the stiffness of the substrate that they colonize, via modifications of the bacterial motility.
Sandipan Dasgupta, Daniella Y Dayagi ... Jeffrey E Gerst
The RNA transferome comprises full-length mRNAs and lncRNAs that undergo non-selective and expression-dependent transfer between mammalian cells in culture via actin-based tunneling nanotubes.