Browse our latest research

Page 517 of 1,760
    1. Immunology and Inflammation

    The meningeal transcriptional response to traumatic brain injury and aging

    Ashley C Bolte, Daniel A Shapiro ... John R Lukens
    Transcriptional analyses provide an atlas of how traumatic brain injury and aging shape meningeal cell composition and gene expression.
    1. Genetics and Genomics
    2. Neuroscience

    Monoallelic CRMP1 gene variants cause neurodevelopmental disorder

    Ethiraj Ravindran, Nobuto Arashiki ... Angela M Kaindl
    Genetic finding of pathogenic CRMP1 variants in three unrelated individuals with neurodevelopmental disorder, supported by structural simulation, biochemical and proof-of-principle data highlights the key role of CRMP1 in the development and functioning of the nervous system in humans.
    1. Neuroscience

    Rostral and caudal basolateral amygdala engage distinct circuits in the prelimbic and infralimbic prefrontal cortex

    Kasra Manoocheri, Adam G Carter
    The prelimbic and infralimbic prefrontal cortex (PFC) process distinct inputs from rostral and caudal basolateral amygdala (BLA), which engage different populations of projection neurons, via both direct connections and polysynaptic activity within the local network.
    1. Neuroscience

    Homeostatic regulation through strengthening of neuronal network-correlated synaptic inputs

    Samuel J Barnes, Georg B Keller, Tara Keck
    Following sensory deprivation in adult mice, homeostatic synaptic strengthening occurs in non-sensory network responsive synapses, but not in sensory responsive synapses, despite homeostatic increases to the global sensory-evoked responses.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Complementary evolution of coding and noncoding sequence underlies mammalian hairlessness

    Amanda Kowalczyk, Maria Chikina, Nathan Clark
    Studying the genomes of mammals with sparse hair covering identifies specific genes and regulatory regions responsible for the formation of hair and skin, some of which were previously unrecognized.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    m6A modification of U6 snRNA modulates usage of two major classes of pre-mRNA 5’ splice site

    Matthew T Parker, Beth K Soanes ... Gordon G Simpson
    High throughput sequencing of Arabidopsis mutants lacking the U6 snRNA methyltransferase FIONA1/METTL16 uncovers the role of U6 methylation in splicing signal preferences.
    1. Cancer Biology
    2. Immunology and Inflammation

    VLA-4 suppression by senescence signals regulates meningeal immunity and leptomeningeal metastasis

    Jiaqian Li, Di Huang ... Ying Wang
    Senescence signals in tumor-specific cytotoxic T lymphocytes inhibit their trafficking from deep cervical lymph nodes to meninges via downregulating VLA-4, leading to leptomeningeal metastasis.
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    Survival of mineral-bound peptides into the Miocene

    Beatrice Demarchi, Meaghan Mackie ... Julia Clarke
    Ostrich eggshell from the Liushu Formation in northwestern China push ancient protein preservation into the Miocene.
    1. Neuroscience

    LabNet hardware control software for the Raspberry Pi

    Alexej Schatz, York Winter
    A software distributed platform for the Raspberry Pi to simplify and unify hardware access over the Ethernet network with almost real-time latencies.
    1. Cell Biology

    Heterogeneous levels of delta-like 4 within a multinucleated niche cell maintains muscle stem cell diversity

    Susan Eliazer, Xuefeng Sun ... Andrew S Brack
    A gradient of Mib1-Dll4 within multinucleated muscle fibers maintains a continuum of metastable states within the muscle stem cell pool during tissue homeostasis.