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Quantitative imaging of neurons reveals how opioid agonists produce long-term functional tolerance at presynaptic terminals through rapid internalization of receptors from the axonal surface.

A novel machine learning approach improves quantitative comparisons of mouse and human brains using spatial transcriptomics data sets.

Tracking of all cells in intestinal organoids crypts to fully reconstruct cell lineages reveals that proliferative behavior is highly symmetric between sisters cells, while simulations show that this observed symmetry minimizes random fluctuations in cell proliferation, thereby ensuring homeostasis.

A novel species-sorting experiment finds that phylogenetically and functionally distinct microbial communities emerge under different temperature conditions due to the resuscitation of latent diversity.

When non-glycosylated, Seipin, which spans the endoplasmic reticulum (ER) membrane twice, forms aggregates in an oligomerization-dependent manner, distorts the shape of the ER, and incorporates SERCA2b via direct interaction, inactivation of which results in induction of ER stress and apoptosis.

Self-organization based on a feedback loop between cell geometry and division plane positioning plays a central role in the building of tissue architectures in Arabidopsis thaliana embryo through both stereotyped and variable division patterns.

GLMsingle is a publicly available toolbox for analyzing fMRI time-series data that leverages data-driven optimization techniques to improve the accuracy of single-trial BOLD response estimates.

Cells of the mammalian cochlea can be reprogrammed to produce mechanosensory hair cells, but epigenetic changes in the cochlea make this process less efficient with age.

Unsupervised clustering of the heterogeneous functional brain organization in autism reveals generalizable patterns of connectivity alterations that extend to the general population.

Two distinct objects evoke fluctuating activity in visual cortex in a manner that could preserve information about both items.