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A combination of mathematical modeling and live-cell imaging reveals a strategy for the rational control over cell electrophysiology though modulation of ion channel expression.

Mice made obese by feeding a high starch diet do not develop insulin resistance like mice made similarly obese by a high fat diet and this is associated with differences in specific bioactive ceramide species in liver and muscle tissue.

Zeno SWATH MS, a novel data-independent acquisition technique in proteomics, which by facilitating sensitive detection in high-throughput experiments with low sample amounts, mitigates current bottlenecks of high-throughput proteomics.

A digital flesh model of the sail-backed dinosaur Spinosaurus was tested and performed very poorly in water, favoring the view of this dinosaur as a two-legged, wading ambush predator of large fish in shallow waterways and not an aquatic dinosaur.

Proteomics uncovers thus far unknown age and sex differences in sciatic nerve and skin of naïve mice, highlighting the importance of adequate age matching and parallel investigation of male and female mice in biomedical studies.

In the fungal pathogen Cryptococcus neoformans, the RAM pathway, potentially through post-transcriptional regulation, plays an essential role in adaptation to host temperature and CO₂.

Comprehensive transcriptomic analyses describe the underlying tumorigenic gene expression state in the invasive Drosophila follicle cells following the loss of epithelial cell polarity and identify a non-canonical role of Keap1-Nrf2 signaling in regulating collective cell invasion.

SIMC1 and SLF1 bind exclusively to SLF2 to form two separate complexes that direct the human SMC5/6 complex to its antiviral defense or DNA lesion repair activities.

Approximately half of the associations identified between attention-deficit/hyperactivity disorder and brain morphology in two large independent studies of adolescents are likely due to confounding bias by socioeconomic and parental behavioral factors.

Strains of the bacterium Pseudomonas aeruginosa that use secondary metabolism to make surfactants and change the surface tension of the liquid that surrounds them do so only if they can first meet their primary metabolic needs.