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Lactate-Ndrg1a signaling protects the kidney from hypoxic injury and functions partly by inducing reversible degradation of the ATP-demanding sodium-potassium ATPase pump.

Biased growth of microtubules in the advancing axon tip contributes to the uniform orientation of microtubules in mature axons, which is essential for proper neuronal functioning.

In Drosophila, genomic CRISPR/Cas9 expression necessary for CRISPR-based gene drives harbors fitness costs presumably caused by off-target effects, which can be minimized by using a high-fidelity version of Cas9.

A horizontally shared type VI secretion system affects the interaction between vibrios and eukaryotic hosts.

Blood donor serosurveillance in eight of Brazil’s most populous cities reveals extensive variation of SARS-CoV-2 attack rate across cities, age, and sex groups in December 2020 and increased intrinsic severity of the Gamma variant of concern.

The motility of three different kinesin-dynein pairs were analyzed and found to be strikingly similar, suggesting that bidirectional transport is not regulated by motor type, but rather by scaffold, adapter, and regulatory proteins.

Drosophila enteroblasts form septate junctions, an apical domain and an internal lumen inside the midgut epithelium before they reach the gut surface, thereby maintaining the intestinal barrier as they integrate.

Novel variants in the BRC repeat region of BRCA2 were identified and comprehensively characterized as either deleterious or benign.

Phylogenetic evidence suggests that the majority of HIV infections occurring in the UNAIDS Fast-track city Amsterdam continue to have an Amsterdam resident as source, indicating that the majority of HIV infections in Amsterdam could be prevented through city-level interventions.

A survey of the transcriptomic landscape of the mouse ovary at the single-cell level reveals both the cellular complexity of this organs and the dynamic nature of the cellular states that accompany estrous cycling.