Browse our latest research

Page 549 of 1,737
    1. Physics of Living Systems

    Alternation emerges as a multi-modal strategy for turbulent odor navigation

    Nicola Rigolli, Gautam Reddy ... Massimo Vergassola
    A tracking animal's decision to intermittently pause and sniff the air reflects its belief that it is far downwind of the odor source, where benefits of sensing rare airborne cues outweigh the cost of pausing.
    1. Neuroscience

    Neuroscout, a unified platform for generalizable and reproducible fMRI research

    Alejandro de la Vega, Roberta Rocca ... Tal Yarkoni
    A web-based analysis platform for public fMRI data using naturalistic stimuli, leveraging state-of-the-art feature extraction models to enable more generalizable and reproducible findings.
    1. Structural Biology and Molecular Biophysics

    Structures of topoisomerase V in complex with DNA reveal unusual DNA-binding mode and novel relaxation mechanism

    Amy Osterman, Alfonso Mondragón
    Structural and biochemical studies explain the topoisomerase V DNA relaxation mechanism by showing that it adopts an unusual conformation when bound to DNA that exposes the active site.
    1. Neuroscience

    Experience-driven rate modulation is reinstated during hippocampal replay

    Margot Tirole, Marta Huelin Gorriz ... Daniel Bendor
    Hippocampal place cells modulate their firing rate during replay events to reflect the increases, or decreases, in firing rate experienced between contexts during behavior.
    1. Evolutionary Biology

    Transition to siblinghood causes a substantial and long-lasting increase in urinary cortisol levels in wild bonobos

    Verena Behringer, Andreas Berghänel ... Gottfried Hohmann
    In wild bonobos, sibling birth induced a sudden increase in urinary cortisol levels in the older offspring, a physiological response that occurred in all subjects and was independent of their age.
    1. Cancer Biology
    2. Immunology and Inflammation

    Transient cell-in-cell formation underlies tumor relapse and resistance to immunotherapy

    Amit Gutwillig, Nadine Santana-Magal ... Yaron Carmi
    Tumors escape killing by the immune system through generating transient spatial cell-in-cell structures that are impenetrable to cytotoxic compounds including lytic granules and chemotherapy.
    1. Computational and Systems Biology

    Network design principle for robust oscillatory behaviors with respect to biological noise

    Lingxia Qiao, Zhi-Bo Zhang ... Lei Zhang
    Searching all two- and three-node gene regulatory network topologies identifies the repressilator with positive autoregulation as the motif capable of accurate oscillation and reveals the long period and high amplitude as two distinct mechanisms for buffering different noise.
    1. Neuroscience

    Distance estimation from monocular cues in an ethological visuomotor task

    Philip RL Parker, Elliott TT Abe ... Cristopher M Niell
    Mice accurately perform an ethological distance estimation task based on gap jumping and can use monocular cues to estimate distance in addition to binocular cues such as stereopsis.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Global chromatin mobility induced by a DSB is dictated by chromosomal conformation and defines the HR outcome

    Fabiola García Fernández, Etienne Almayrac ... Emmanuelle Fabre
    A designed system to track homologous recombination (HR) in vivo demonstrates the importance of chromosome organization in the induction of global mobility in response to double-strand breaks and characterizes the role of two types of global motility in HR.
    1. Neuroscience

    Seizures, behavioral deficits, and adverse drug responses in two new genetic mouse models of HCN1 epileptic encephalopathy

    Andrea Merseburg, Jacquelin Kasemir ... Bina Santoro
    Two genetic mouse models for HCN1-linked developmental epileptic encephalopathy display distinct biophysical changes in HCN1 ion channel properties but similar worsening of seizures in response to antiepileptic drugs, thereby recapitulating key features of the human disease.