The targeted removal of legacy bisphosphonate from the jawbone by competitive equilibrium therapy not only elucidated the pathological mechanism of bisphosphonate-related osteonecrosis of the jaw (BRONJ) but also established a highly translatable therapeutic option for BRONJ.
A tracking animal's decision to intermittently pause and sniff the air reflects its belief that it is far downwind of the odor source, where benefits of sensing rare airborne cues outweigh the cost of pausing.
Alejandro de la Vega, Roberta Rocca ... Tal Yarkoni
A web-based analysis platform for public fMRI data using naturalistic stimuli, leveraging state-of-the-art feature extraction models to enable more generalizable and reproducible findings.
Structural and biochemical studies explain the topoisomerase V DNA relaxation mechanism by showing that it adopts an unusual conformation when bound to DNA that exposes the active site.
Margot Tirole, Marta Huelin Gorriz ... Daniel Bendor
Hippocampal place cells modulate their firing rate during replay events to reflect the increases, or decreases, in firing rate experienced between contexts during behavior.
Verena Behringer, Andreas Berghänel ... Gottfried Hohmann
In wild bonobos, sibling birth induced a sudden increase in urinary cortisol levels in the older offspring, a physiological response that occurred in all subjects and was independent of their age.
Amit Gutwillig, Nadine Santana-Magal ... Yaron Carmi
Tumors escape killing by the immune system through generating transient spatial cell-in-cell structures that are impenetrable to cytotoxic compounds including lytic granules and chemotherapy.
Searching all two- and three-node gene regulatory network topologies identifies the repressilator with positive autoregulation as the motif capable of accurate oscillation and reveals the long period and high amplitude as two distinct mechanisms for buffering different noise.
Philip RL Parker, Elliott TT Abe ... Cristopher M Niell
Mice accurately perform an ethological distance estimation task based on gap jumping and can use monocular cues to estimate distance in addition to binocular cues such as stereopsis.
Fabiola García Fernández, Etienne Almayrac ... Emmanuelle Fabre
A designed system to track homologous recombination (HR) in vivo demonstrates the importance of chromosome organization in the induction of global mobility in response to double-strand breaks and characterizes the role of two types of global motility in HR.
