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Tracking proteins in live cells is challenging due to technical limitations and biological complexity, but approaches based in Bayesian nonparametrics stand a decent chance at recovering a target protein's dynamic profile from noisy data.

A viral heliorhodopsin from Emiliania huxleyi virus 202 (V2HeR3) is a light-activated proton transporter, which has the potential to depolarize the host cells by light, possibly to overcome the host defense mechanisms or to prevent superinfection.

A deep learning-based image classification pipeline unleashes automated division counting and replicative lifespan analyses of single cells growing in microfluidic cellular traps.

Comparing the relative similarity of cellular molecules to alternate templates allows classification of related complexes in the cell using fewer particles than needed for 3D classification and is more practicable for low abundance complexes.

Local ATP production by the plasma membrane-associated glycolytic enzyme pyruvate kinase is essential for the nutrient-dependent closure of the ATP-sensitive potassium channels that initiate insulin release from pancreatic β-cells.

Systematic analysis of behavioral maturation in the Caenorhabditis elegans embryo reveals a stereotyped developmental progression, including rhythmic behavioral quiescence elicited by a sleep-promoting neuron (RIS) releasing somnogenic peptides (FLP-11).

Multiobjective artificial selection methods from evolutionary computing show promise for improving directed evolution outcomes when selecting for multiple traits of interest.

Homologous recombination rates tend to be highest in the most conserved parts of bacterial genomes.

Molecular, laminar, and regional characterization in combination with classical and conditional tracing techniques reveal that medial prefrontal cortical neurons innervating the nucleus accumbens and the ventral tegmental area form distinct populations.

Four conserved ciliary localization signals in the Joubert syndrome-associated INPP5E phosphoinositide phosphatase control its ciliary accumulation.