Single-cell time-lapse imaging and optogenetical gene recombination system uncovered that bacteria cells can overcome a deleterious genetic change of antibiotic resistance gene deletion depending on their environmental histories.
Deciphering the mechanism of action of a large family of natural and synthetic cytotoxic lipids bioactivated by enantiospecific oxidation into protein-reactive species inspires the development of enzyme-specific prodrugs.
Fungi that produce mushrooms have a unique life cycle with two haploid nuclei, instead of a diploid nucleus, this allows additional matings and selection at the level of the nucleus, even with a fitness trade-off.
A streamlined form of the bacterial System I cytochrome c biogenesis machinery in archaea was characterized using Methanosarcina acetivorans as a model system.
Chi-Hong Wu, Vedakumar Tatavarty ... Gina G Turrigiano
Activity-dependent bidirectional changes in phosphorylation of the autism-associated scaffold protein Shank3 are essential for the expression of homeostatic synaptic plasticity.
Robert Warneford-Thomson, Parisha P Shah ... Roberto Bonasio
COV-ID is a highly scalable technology that utilizes a two-step barcoding strategy to detect viral RNAs in saliva samples combining RT-LAMP, PCR, and next generation sequencing.
Andrea Toledo, Mathieu Letellier ... Olivier Thoumine
MDGAs are highly diffusive molecules that alter both neuroligin-1 and AMPA receptor dynamics and function, thereby significantly delaying the differentiation of excitatory post-synapses.
A novel mouse model which permits tracking of papillomavirus infected cells in mouse stratified epithelia during early infection by means of genetic reporter activation.
Klaus Bonazza, Roxana E Iacob ... Timothy A Springer
Both the polypeptide and attached O-glycans N-terminal to the A1 domain in von Willebrand factor lower its affinity for its ligand GPIbα on platelets, its stability, and structural dynamics and decrease population of a high-affinity, intermediate state in unfolding.
