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    1. Neuroscience

    Task-related hemodynamic responses in human early visual cortex are modulated by task difficulty and behavioral performance

    Charlie S Burlingham, Minyoung Ryoo ... Elisha P Merriam
    The fMRI-BOLD signal in human early visual cortex reflects alertness and behavioral performance on the timescale of individual trials.
    1. Cell Biology
    2. Computational and Systems Biology

    Concerted modification of nucleotides at functional centers of the ribosome revealed by single-molecule RNA modification profiling

    Andrew D Bailey, Jason Talkish ... Manuel Ares
    A method enabling identification of more than 100 RNA modifications in single ribosomal RNA molecules uncovers new classes of modified ribosomes.
    1. Cell Biology

    Rapid adaptation of endocytosis, exocytosis, and eisosomes after an acute increase in membrane tension in yeast cells

    Joël Lemière, Yuan Ren, Julien Berro
    Within minutes after an abrupt increase in membrane tension, yeast cells reduce their membrane tension by modulating their rate of endocytosis and exocytosis, and adapt their endocytic actin machinery.
    1. Neuroscience

    Neuronal origins of reduced accuracy and biases in economic choices under sequential offers

    Weikang Shi, Sebastien Ballesta, Camillo Padoa-Schioppa
    Neuronal activity in the primate orbitofrontal cortex reveals different choice biases observed when offers are presented sequentially originate at different stages of the decision process.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Autoinhibition and regulation by phosphoinositides of ATP8B1, a human lipid flippase associated with intrahepatic cholestatic disorders

    Thibaud Dieudonné, Sara Abad Herrera ... Guillaume Lenoir
    Single particle cryo-electron microscopy associated with functional studies reveal a critical role of N- and C-terminal tails in the autoinhibition of the disease-related ATP8B1-CDC50A lipid flippase, the possible role of phosphorylation in autoinhibition relief, and strong activation by PI(3,4,5)P3.
    1. Neuroscience

    The role of V3 neurons in speed-dependent interlimb coordination during locomotion in mice

    Han Zhang, Natalia A Shevtsova ... Ilya A Rybak
    The role of genetically identified V3 interneurons with ascending propriospinal projections in the spinal locomotor circuitry and their contribution to the limb coordination and speed-dependent gait expression during locomotion were investigated using a combination of experimental studies and computational modeling.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Development and characterization of new tools for detecting poly(ADP-ribose) in vitro and in vivo

    Sridevi Challa, Keun W Ryu ... W Lee Kraus
    Poly(ADP-ribose) (PAR) Trackers (PAR-Ts) are optimized PAR sensors that allow the detection and quantification of PAR levels in extracts, living cells, and living tissues with high sensitivity, and with temporal and spatial precision, in many different experimental and biological systems.
    1. Neuroscience

    Drosulfakinin signaling modulates female sexual receptivity in Drosophila

    Tao Wang, Biyang Jing ... Chuan Zhou
    The neuropeptide Drosulfakinin (DSK) functions in a subset of DSK neurons to interact with neural nodes in the sex circuit and acts through its receptor CCKLR-17D3 to control female sexual behavior.
    1. Neuroscience

    Hippocampal-hypothalamic circuit controls context-dependent innate defensive responses

    Jee Yoon Bang, Julia Kathryn Sunstrum ... Junchul Kim
    The hippocampus controls context-dependent defensive behaviors through the anterior hypothalamus, a major component of the medial hypothalamic defense system, by retrieving contextual information essential for avoiding predatory threats and escaping to a safe shelter.
    1. Neuroscience

    The Digital Brain Bank, an open access platform for post-mortem imaging datasets

    Benjamin C Tendler, Taylor Hanayik ... Karla L Miller
    The Digital Brain Bank (open.win.ox.ac.uk/DigitalBrainBank) provides curated post-mortem imaging datasets for neuroanatomy, neuropathology, and comparative neuroanatomy investigations, with the first release containing 21 distinctive whole-brain diffusion MRI datasets, alongside microscopy and complementary MRI modalities.