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A novel bacterial protease activated by a eukaryote-specific factor attacks a host protein involved in cytoskeleton organization to inhibit cell migration during Legionella pneumophila infection.

Persistent Coxiella burnetii infected abdominal aorta aneurysms are associated with an immune-suppressed microenvironment.

Genetic, biochemical, and physiologic analyses reveal differential responses of polyQ SCAs to exercise, and identify Sestrin as a mechanistic target that can be leveraged towards therapeutics for patients unable to exercise, or to supplement the benefits of those who can.

A peptide toxin with therapeutic potential in stroke and pain induces multiple long-lasting conformational changes in acid-sensing ion channels and affects how the channels respond to endogenous ligands.

Analysis of adenylosuccinate lyase (ADSL) deficiency in multiple experimental systems reveals cell and organismal phenotypes and impaired neurodevelopment due to the attenuation of ADSL's roles in distinct pathways.

Genetically modified mouse model and comprehensive analysis reveal the molecular mechanisms regulating early T-cell development through intracellular TCRβ expression-mediated β-selection and independent cell survival signaling.

A computational framework enables the inference of hydrodynamic continuum models for collective cell migration from live-cell imaging data recorded in zebrafish embryos.

Effective navigation of odor plumes in the wild requires that animals sense multiple temporal aspects of odor signals, which are encoded naturally by neurons in the fly olfactory circuit.

Ano1 deletion disrupts Ca²⁺ waves within Kölliker’s organ, reduces burst-firing activity and frequency selectivity of auditory brainstem neurons in the medial nucleus of the trapezoid body, and impairs the functional refinement of its projections to the lateral superior olive.

Lifetime imaging of endogenous metabolic coenzymes is sensitive to dynamic changes in macrophage activation in a live animal, providing a label-free imaging approach to study immunometabolism in vivo with single-cell, spatial, and temporal resolution.