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A multiomics, systems biology approach was used to define the metabolic and signaling programs that drive the fate and function of pancreatic tumor-associated macrophages.

Long-term chemogenetic manipulation of specific cerebellar pathway involving ventral tegmental area revealed a critical role of the pathway as a proactive mediator of the stress-dependent development of depression-like behaviors.

A one-photon three-dimensional light sculpture technique has been developed and demonstrated for high spatio-temporal resolution photostimulation and imaging of dozens of neurons in the intact mouse brain in vivo.

Attention-grabbing tasks produce rapid opioid-mediated analgesia via the descending pain modulation network to alter spinal neuronal activity.

Topoisomerase VI selectively catalyzes strand passage of DNA molecules juxtaposed at close to a right angle, which explains the observed chiral-dependent activity and preferential DNA decatenation versus supercoil relaxation.

Exceptionally preserved small shelly fossils (SSFs) from the early Cambrian Kuanchuanpu Formation (535 million years ago) reveal the muscular system of ancient cnidarians.

Deep convolutional neural networks can generate virtual histology from magnetic resonance imaging (MRI) data to map cellular structures in the mouse brain with high specificity, which enables neurobiologists to use MRI to characterize neuropathology effectively.

Lactic acid bacteria engage a hybrid metabolism which blends features of fermentation and respiration when they perform extracellular electron transfer.

Behavioural and physiological stress response components are integrated on the major axis of genetic covariation, with implications for health and the understanding of the evolutionary response to stressors.

The MIDAS domain of Mdn1, an ATP-driven mechanoenzyme involved in ribosome biogenesis, forms catch bonds with two different ubiquitin-like domain-containing ribosomal assembly factors.