Browse our latest research

Page 675 of 1,751
    1. Immunology and Inflammation

    Overriding impaired FPR chemotaxis signaling in diabetic neutrophil stimulates infection control in murine diabetic wound

    Ruchi Roy, Janet Zayas ... Sasha H Shafikhani
    Therapeutic potential of CCL3 for the treatment of diabetic foot ulcers if it is applied topically after the surgical debridement.
    1. Cell Biology
    2. Immunology and Inflammation

    Functional visualization of NK cell-mediated killing of metastatic single tumor cells

    Hiroshi Ichise, Shoko Tsukamoto ... Michiyuki Matsuda
    Live imaging of the duel of an NK cell versus a metastatic cancer cell on pulmonary epithelial cells reveals a novel survival tactics adopted by cancer cells.
    1. Neuroscience

    Laminar microcircuitry of visual cortex producing attention-associated electric fields

    Jacob A Westerberg, Michelle S Schall ... Jeffrey D Schall
    Simultaneous sampling of electrical voltages outside the brain with neural signals in the cerebral cortex reveals how electrical currents in mosaics of cortical columns produce an electrical signal that can be measured noninvasively to assess the allocation of attention.
    1. Immunology and Inflammation
    2. Stem Cells and Regenerative Medicine

    Hematopoietic stem and progenitor cells improve survival from sepsis by boosting immunomodulatory cells

    Daniel E Morales-Mantilla, Bailee Kain ... Katherine Y King
    Infusion of hematopoietic stem and progenitor cells rescues mice from lethal Group A streptococcal sepsis.
    1. Ecology
    2. Microbiology and Infectious Disease

    Alternate patterns of temperature variation bring about very different disease outcomes at different mean temperatures

    Charlotte Kunze, Pepijn Luijckx ... Ian Donohue
    Temperature variation caused by heatwaves and diurnal fluctuations has distinct effects on host and pathogen traits at different mean temperatures, leading to large and unexpected differences in disease burden making the impact of global warming on diseases hard to predict.
    1. Neuroscience

    Assessing the effects of stress on feeding behaviors in laboratory mice

    Marie Francois, Isabella Canal Delgado ... Lori Zeltser
    Systematic testing of experimental variables in a common neurobehavioral paradigm revealed that conditions that more closely match human physiology reliably elicit stress eating in mice.
    1. Cancer Biology
    2. Cell Biology

    Intravital deep-tumor single-beam 3-photon, 4-photon, and harmonic microscopy

    Gert-Jan Bakker, Sarah Weischer ... Peter Friedl
    Infrared high-pulse-energy low-pulse-repetition-rate excitation advances deep intravital microscopy in strongly scattering tissues such as skin tumors and thick bone, thereby bringing previously inaccessible tumor areas in reach with subcellular resolution.
    1. Cell Biology
    2. Medicine

    Repression of hypoxia-inducible factor-1 contributes to increased mitochondrial reactive oxygen species production in diabetes

    Xiaowei Zheng, Sampath Narayanan ... Sergiu-Bogdan Catrina
    The repression of HIF-1 plays a central role in mitochondrial reactive oxygen species (ROS) overproduction and subsequent tissue damage in diabetes, which is mediated by increased mitochondrial respiration, making HIF-1 signaling an attractive therapeutic target for diabetes complications.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Novel mechanistic insights into the role of Mer2 as the keystone of meiotic DNA break formation

    Dorota Rousová, Vaishnavi Nivsarkar ... John R Weir
    Mer2 interacts directly with meiotic chromatin, axial proteins, and the DNA break forming machinery to facilitate the formation of meiotic double-strand breaks.
    1. Neuroscience

    Mapping dopaminergic projections in the human brain with resting-state fMRI

    Marianne Oldehinkel, Alberto Llera ... Christian F Beckmann
    A functional connectivity gradient in striatum is obtained that maps onto DaT SPECT-derived dopaminergic projections and thereby likely provides a new biomarker for investigating dopaminergic (dys)function in the human brain.