Browse our latest research

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    1. Ecology
    2. Microbiology and Infectious Disease

    Humanization of wildlife gut microbiota in urban environments

    Brian A Dillard, Albert K Chung ... Andrew H Moeller
    Urban wildlife harbor gut bacteria found in humans but missing from rural wildlife, consistent with bacterial transmission from humans to wildlife in cities.
    1. Neuroscience

    Distinct representation of cue-outcome association by D1 and D2 neurons in the ventral striatum’s olfactory tubercle

    Nuné Martiros, Vikrant Kapoor ... Venkatesh N Murthy
    Real-time imaging of neural activity in behaving mice reveals that the two canonical types of neurons in the olfactory tubercle carry distinct information about learned odor cues, with D1 neurons representing stimulus valence and D2 neurons mainly representing stimulus identity.
    1. Neuroscience

    Multiple timescales of sensory-evidence accumulation across the dorsal cortex

    Lucas Pinto, David W Tank, Carlos D Brody
    Sensory-evidence accumulation is a distributed cortical computation, but frontal cortical areas contribute to accumulation on longer timescales than posterior cortical areas.
    1. Neuroscience

    Self-organization of in vitro neuronal assemblies drives to complex network topology

    Priscila C Antonello, Thomas F Varley ... Jean Faber
    Effectively connected neurons self-organize forming networks with a small-world architecture composed of modules, with most likely few and nearby neurons, integrated by more topologically important and high firing rate neurons.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Dynamics of allosteric regulation of the phospholipase C-γ isozymes upon recruitment to membranes

    Edhriz Siraliev-Perez, Jordan TB Stariha ... John Sondek
    PLC-γ isozymes are activated by a combination of receptor engagement and membrane proximity.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    On demand expression control of endogenous genes with DExCon, DExogron and LUXon reveals differential dynamics of Rab11 family members

    Jakub Gemperle, Thomas S Harrison ... Patrick T Caswell
    DExCon, LUXon, and DExogron approaches simultaneously block endogenous gene expression and permit tuning of re-expression levels in time and space; proof-of-principle reveals unforeseen differences in protein kinetics, cargo handling, and cell migration regulation between closely related Rab11 family members.
    1. Stem Cells and Regenerative Medicine

    GSK3 inhibition rescues growth and telomere dysfunction in dyskeratosis congenita iPSC-derived type II alveolar epithelial cells

    Rafael Jesus Fernandez, Zachary JG Gardner ... F Brad Johnson
    Telomere dysfunction in iPSC-derived type II alveolar epithelial cells causes senescence and gene expression changes including Wnt-related changes that GSK3 inhibition can rescue, providing insight into pulmonary fibrosis pathogenesis.
    1. Neuroscience

    Spontaneous neuronal oscillations in the human insula are hierarchically organized traveling waves

    Anup Das, John Myers ... Sameer A Sheth
    Human intracranial electroencephalographic recordings reveal the electrophysiological properties and hierarchical organization of spontaneous neuronal oscillations in the human insula and show that these oscillations are traveling waves, thus providing new insights into intrainsular and interinsular communication.
    1. Neuroscience

    Inhibitory control of frontal metastability sets the temporal signature of cognition

    Vincent Fontanier, Matthieu Sarazin ... Emmanuel Procyk
    Single unit recordings in monkeys and biophysical modelling demonstrate that local inhibitory-controlled metastable neural states specify the temporal organization of cognitive functions in frontal areas.
    1. Neuroscience

    Semantic relatedness retroactively boosts memory and promotes memory interdependence across episodes

    James W Antony, America Romero ... Kelly A Bennion
    The more semantically related a later experience is to an earlier one (along multiple dimensions), the more likely humans are to think back to and strengthen the memory of the earlier experience and mentally link the two experiences.