Browse our latest research

Page 698 of 1,840
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Repressing PTBP1 fails to convert reactive astrocytes to dopaminergic neurons in a 6-hydroxydopamine mouse model of Parkinson’s disease

    Weizhao Chen, Qiongping Zheng ... Mingtao Li
    Repressing astroglial PTBP1 by shRNA or antisense oligonucleotide fails to convert astrocyte to neuron including dopaminergic neuron in a 6-OHDA mouse model of PD.
    1. Developmental Biology

    Amoeboid-like migration ensures correct horizontal cell layer formation in the developing vertebrate retina

    Rana Amini, Archit Bhatnagar ... Caren Norden
    Horizontal cell undergoes amoeboid-like migration in the developing vertebrate retina, a not previously reported migration mode in the central nervous system, that allows them to move within a densely packed tissue without predetermined paths.
    1. Microbiology and Infectious Disease

    NAD kinase promotes Staphylococcus aureus pathogenesis by supporting production of virulence factors and protective enzymes

    Clarisse Leseigneur, Laurent Boucontet ... Olivier Dussurget
    Staphylococcus aureus NAD kinase promotes infection by protecting bacteria from host antimicrobial defenses and by supporting production of major virulence factors.
    1. Physics of Living Systems

    The role of surface adhesion on the macroscopic wrinkling of biofilms

    Steffen Geisel, Eleonora Secchi, Jan Vermant
    The three-dimensional structure of bacterial biofilms is governed by a buckling-delamination process that is determined by basic physical parameter that allow us to predict and control the biofilm morphology.
    1. Biochemistry and Chemical Biology
    2. Plant Biology

    A dual-target herbicidal inhibitor of lysine biosynthesis

    Emily RR Mackie, Andrew S Barrow ... Tatiana P Soares da Costa
    The first recently discovered inhibitors of lysine biosynthesis with in planta activity have a dual-target mode of action, which provides proof-of-concept for the development of multi-target ‘resistance-resistant’ herbicides with a novel mode of action.
    1. Neuroscience

    Minian, an open-source miniscope analysis pipeline

    Zhe Dong, William Mau ... Denise J Cai
    Minian is an open-source analysis pipeline for calcium imaging data that enhances usability with low memory demands and transparency with user-friendly interactive visualizations.
    1. Epidemiology and Global Health
    2. Evolutionary Biology

    Selection for infectivity profiles in slow and fast epidemics, and the rise of SARS-CoV-2 variants

    François Blanquart, Nathanaël Hozé ... Simon Cauchemez
    Selection acting on SARS-CoV-2 variants altering the infectivity profile depends on levels of transmission in the community, and this dependence is used to infer Alpha and Delta variants infectivity profiles.
    1. Genetics and Genomics
    2. Medicine

    A genome-wide functional genomics approach uncovers genetic determinants of immune phenotypes in type 1 diabetes

    Xiaojing Chu, Anna WM Janssen ... Yang Li
    Deep immunophenotyping characterizes the genetic factors influencing immune functionality in patients with type 1 diabetes.
    1. Neuroscience

    Partial response electromyography as a marker of action stopping

    Liisa Raud, Christina Thunberg, René J Huster
    Partial response electromyography is a useful and reliable measure of action stopping in a stop signal task, supported by psychometric and meta-analytic evidence.
    1. Genetics and Genomics
    2. Neuroscience

    Elevated brain-derived cell-free DNA among patients with first psychotic episode – a proof-of-concept study

    Asael Lubotzky, Ilana Pelov ... Yoav Kohn
    Liquid biopsy methods utilizing brain-specific cell-free DNA methylation markers can detect brain cell death and potentially assist early detection and monitoring of schizophrenia.