Browse our latest research

Page 712 of 1,744
    1. Cell Biology
    2. Medicine

    An experimental test of the effects of redacting grant applicant identifiers on peer review outcomes

    Richard K Nakamura, Lee S Mann ... Bruce Reed
    Redaction, intended to obscure personal and institutional identity, reduced the gap between Black vs. White applicants in simulated review of real NIH scientific grant applications, thus providing qualified support for double-blinded models of peer review.
    1. Neuroscience

    Distinct dendritic Ca2+ spike forms produce opposing input-output transformations in rat CA3 pyramidal cells

    Ádám Magó, Noémi Kis ... Judit K Makara
    Dendritic patch-clamp recordings combined with two-photon imaging and glutamate uncaging reveal two types of regenerative calcium spikes in the dendrites of CA3 pyramidal neurons from rat hippocampus.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Mycobacterium tuberculosis canonical virulence factors interfere with a late component of the TLR2 response

    Amelia E Hinman, Charul Jani ... Amy K Barczak
    The pathogenic success of Mycobacterium tuberculosis relies in part on its ability to blunt a component of the TLR2-dependent immune response.
    1. Developmental Biology
    2. Genetics and Genomics

    Paths and pathways that generate cell-type heterogeneity and developmental progression in hematopoiesis

    Juliet R Girard, Lauren M Goins ... Utpal Banerjee
    A combination of mRNA sequencing and genetic analysis reveals mechanisms that govern the development of distinct differentiated blood cell types from hematopoietic progenitors.
    1. Immunology and Inflammation

    Protein kinase Cδ is essential for the IgG response against T-cell-independent type 2 antigens and commensal bacteria

    Saori Fukao, Kei Haniuda ... Daisuke Kitamura
    Protein kinase Cδ, a kinase downstream of B-cell antigen receptor, is found to be essential for class switching to and production of IgG in the T-cell-independent type 2 immune response and for regulation of gut-residing bacteria.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The Shu complex prevents mutagenesis and cytotoxicity of single-strand specific alkylation lesions

    Braulio Bonilla, Alexander J Brown ... Kara A Bernstein
    The Shu complex enables lesion bypass of specific alkylation-induced DNA damage including abasic sites and 3-methyl-cytosine.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Cross-reactive antibodies after SARS-CoV-2 infection and vaccination

    Marloes Grobben, Karlijn van der Straten ... Marit J van Gils
    SARS-CoV-2 infection and vaccination elicit antibodies that cross-react with other human coronavirus spike proteins, indicating the spike S2 subdomain as a potential target strategy to develop a pan-coronavirus vaccine.
    1. Evolutionary Biology

    New fossils of Australopithecus sediba reveal a nearly complete lower back

    Scott A Williams, Thomas Cody Prang ... Lee R Berger
    Newly recovered lumbar vertebrae belonging to Malapa Hominin 2, an adult female of the fossil hominin species Australopithecus sediba, demonstrate that this individual was adapted to upright posture and bipedal locomotion but also had adaptations for climbing in trees.
    1. Cancer Biology
    2. Genetics and Genomics

    BRAFV600E induces reversible mitotic arrest in human melanocytes via microRNA-mediated suppression of AURKB

    Andrew S McNeal, Rachel L Belote ... Robert L Judson-Torres
    Oncogenic BRAF causes genome duplication and reversible growth arrest in human melanocytes that is conditional on microRNA expression and differentiation state.
    1. Cell Biology
    2. Neuroscience

    Giant ankyrin-B mediates transduction of axon guidance and collateral branch pruning factor sema 3A

    Blake A Creighton, Simone Afriyie ... Damaris N Lorenzo
    Giant ankyrin-B enables the transduction of Sema 3A repelling cues and is important for normal axonal connectivity.