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    1. Cell Biology

    JAK-STAT pathway activation compromises nephrocyte function in a Drosophila high-fat diet model of chronic kidney disease

    Yunpo Zhao, Jianli Duan ... Zhe Han
    A conserved signaling axis linking Drosophila adipose tissue to nephrocyte function reveals how obesity can drive kidney dysfunction and points to new opportunities for therapeutic intervention.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Hybridization breaks species barriers in long-term coevolution of a cyanobacterial population

    Gabriel Birzu, Harihara Subrahmaniam Muralidharan ... Devaki Bhaya
    Analysis of hundreds of single-cell genomes from Yellowstone National Park shows bacterial species are less cohesive than previously thought.
    1. Neuroscience

    Coordinated spinal locomotor network dynamics emerge from cell-type-specific connectivity patterns

    F David Wandler, Benjamin K Lemberger ... James M Murray
    A hierarchy of models guided by experimental results from zebrafish shows that coordinated, variable-speed locomotion can emerge from network-level interactions among interneuron populations with structured spatial connectivity.
    1. Neuroscience

    Decision-making components and times revealed by the single-trial electroencephalogram

    Gabriel Weindel, Jelmer P Borst, Leendert van Maanen
    By modeling the single-trial electroencephalogram of participants performing perceptual decisions, and building on predictions from two century-old psychological laws, we estimate the times of information processing steps contained in decision-making.
    1. Neuroscience

    Prolonged oscillating kisspeptin neuron activity underlies the preovulatory luteinizing hormone surge in mice

    Ziyue Zhou, Cheng-Yu Huang, Allan E Herbison
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Neuroscience

    Retrosplenial cortex enables context-dependent goal-directed sensorimotor transformation

    Pol Bech, Robin F Dard ... Carl CH Petersen
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Immunology and Inflammation

    Epidermal resident memory T cell fitness requires antigen encounter in the skin

    Eric S Weiss, Toshiro Hirai ... Daniel H Kaplan
    Antigen-driven TCR signaling in the epidermis during CD8+ TRM differentiation results in a lower TGFβ requirement for persistence and increased proliferative capacity that together enhance epidermal TRM fitness.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Evolution of a fuzzy ribonucleoprotein complex in viral assembly

    Huaying Zhao, Tiansheng Li ... Peter Schuck
    The stability of ribonucleoprotein complexes of SARS-CoV-2 nucleocapsid proteins differs among variants of concern and the viral evolution of nucleocapsid protein can be understood in the framework of fuzzy complexes.
    1. Neuroscience

    Continuous developmental changes in word recognition support language learning across early childhood

    Michael C Frank, Virginia A Marchman ... Martin Zettersten
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience

    A differentiable model for optimizing the genetic drivers of synaptogenesis

    Tommaso Boccato, Matteo Ferrante, Nicola Toschi
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
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