Emerson M Carmona, William N Zagotta, Sharona E Gordon
A fluorescent noncanonical amino acid enables structural measurements across full-length human voltage-gated proton channel (Hv1) and reveals zinc-dependent conformational changes.
Single-cell and bulk lineage tracing reveals that adult bone marrow endothelial cells generate functional hematopoietic progenitor and mature blood cells, expanding the cell sources of postnatal hematopoiesis.
The thermosensory neuron AFD unexpectedly modulates locomotion based on tactile experience through molecular and circuit mechanisms distinct from those underlying thermosensation.
Genetic experiments combined with cellular and biochemical analyses including lipidomics performed by imaging mass spectrometry reveal that the capacity of mature B lymphocytes and germinal center B cells to synthesize some ether phospholipids is vital for normal humoral responses.
Computer simulations reveal the structural basis for a selective mechanism of ion-channel inhibition that could guide future pharmacological developments against associated human health disorders.
