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Replication origins in Trypanosoma brucei integrate multiple features previously described individually in opisthokonts, revealing a unified structural topology built from strand-specific nucleotide composition, G‑quadruplex enrichment, and distinctive nucleosome patterns.

Exposure of human cortical interneurons to hypoxia leads to decreased migration, a process that is likely altered in preterm infants and contributes to the increased risk for neurodevelopmental problems.

A novel bilateral compensatory mechanism important for the activity of olfactory glomeruli in Xenopus tropicalis tadpoles was uncovered.

Biochemical and genetic evidence identifies ATP5I as a biguanide target, redefining biguanide action through ATP synthase regulation and assembly, mitochondrial architecture, and mitochondrial protein turnover.

Selective engagement of suprapyramidal dentate gyrus neurons during a high-demand pattern separation task reveals blade-specific circuit engagement for enhancing mnemonic discrimination.

Meta-analysis indicates that network-targeted non-invasive brain stimulation consistently enhances memory function supported by the hippocampal network, thus providing robust evidence that specific memory abilities rely on specific modifiable brain networks.

A newly developed chemo-immunological strategy enabled detection of acetoacetate-mediated lysine acetoacetylation, identified the associated regulatory enzymes, and revealed its distinct biological functions and physiological significance.