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    1. Structural Biology and Molecular Biophysics

    Dissecting mechanisms of ligand binding and conformational changes in the glutamine-binding protein

    Zhongying Han, Sabrina Panhans ... Thorben Cordes
    A range of biophysical techniques is used in combination with computational analysis to understand whether glutamine-binding protein binds its ligand via the induced-fit or conformational selection mechanism.
    1. Chromosomes and Gene Expression

    Interplay between cohesin and TORC1 links chromosome segregation and gene expression to environmental changes

    Dorian Besson, Sabine Vaur ... Jean-Paul Javerzat
    A conserved kinase network links nutrient sensing to chromosome segregation and gene regulation by modulating cohesin dynamics through phosphorylation.
    Version of Record
    Research Article
    • Important
    • Compelling
    • Convincing
    1. Evolutionary Biology
    2. Neuroscience

    Distinct evolutionary trajectories of two integration centres, the central complex and mushroom bodies, across Heliconiini butterflies

    Max S Farnworth, Yi Peng Toh ... Stephen H Montgomery
    A cognitive adaptation in Heliconius butterflies, accompanied by strikingly divergent changes in two principal insect integration centres, reveals that neural circuits can differ strongly in their propensity for evolutionary change.
    1. Immunology and Inflammation

    Beta-Glucan modulates monocyte plasticity and differentiation capacity to mitigate DSS-induced colitis

    Yinyin Lv, Yanyun Fan ... Hongzhi Xu
    Trained monocytes alleviate DSS-induced colitis via bacterial clearance and monocyte differentiation reprogramming.
    1. Developmental Biology

    Mural cells protect the adult brain from hemorrhage but do not control the blood–brain barrier in developing zebrafish

    Oguzhan F Baltaci, Andrea Usseglio Gaudi ... Benjamin M Hogan
    Pericytes regulate cerebrovascular development, while vascular smooth muscle cells prevent hemorrhage and blood–brain barrier breakdown at vascular hotspots in juvenile and adult zebrafish.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A miniaturized MR1 metabolite display system with native-like protein features

    Photis Rotsides, Omkar Shinde ... Nikolaos G Sgourakis
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Evolutionary Biology

    Bacterial ancestry of the mitochondrial ATP exporter

    Jotin Gogoi, Rajan Sankaranarayanan
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Neuroscience

    Examining Alzheimer’s Disease modifiable risk factors: Impact of physical activity and diet on neuroanatomy and behaviour in mouse models

    Cindy L García, Chloe Anastassiadis ... M Mallar Chakravarty
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Neuroscience

    Decentralized Clocks and Direct Photoreception: The Zebrafish as an Integrative Model for Circadian Biology

    Wang Liao, Chun-jiao Wei ... Da-long Ren
    Not revised
    Reviewed Preprint v1
    1. Genetics and Genomics
    2. Plant Biology

    Uncovering genetic mechanisms underlying trait variation in switchgrass using explainable artificial intelligence

    Paulo Izquierdo, Xiaoyu Weng ... Shin-Han Shiu
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
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