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    1. Structural Biology and Molecular Biophysics

    Conformational changes, excess area, and elasticity of the Piezo protein-membrane nanodome from coarse-grained and atomistic simulations

    Sneha Dixit, Frank Noé, Thomas R Weikl
    Piezo proteins induce a curved protein-membrane nanodome with an excess area of about 40 nm2 in tensionless membranes and resist tension-induced flattening with a force constant of about 60 pN/nm.
    1. Neuroscience

    Online reinforcement learning of state representation in recurrent network supported by the power of random feedback and biological constraints

    Takayuki Tsurumi, Ayaka Kato ... Kenji Morita
    Recurrent neural network and its readout (cortex–striatum) can learn state representation and value using online random-weight feedback of temporal-difference reward-prediction-error (dopamine) through feedback alignment or biological non-negative-weight constraint-induced loose alignment.
    1. Developmental Biology

    Atoh1 is required for the formation of lateral line electroreceptors and hair cells, whereas FoxG1 represses an electrosensory fate

    Martin Minařík, Alexander S Campbell ... Clare VH Baker
    Targeting Atoh1 for CRISPR/Cas9-mediated mutagenesis in sturgeon results in missing electroreceptors as well as mechanosensory hair cells, supporting conserved developmental mechanisms, whereas ectopic electrosensory organs develop after targeting mechanosensory-restricted Foxg1, suggesting FoxG1 directly or indirectly represses electrosensory organ formation.
    1. Neuroscience

    A Priming Circuit Controls the Olfactory Response and Memory in Drosophila

    He Yang, Yang Jiang, Samuel Kunes
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Computational and Systems Biology

    Regulation of Transcriptional Bursting and Spatial Patterning in Early Drosophila Embryo Development

    César Nieto, Zahra Vahdat ... Abhyudai Singh
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Altered cognitive processes shape tactile perception in autism

    Ourania Semelidou, Mathilde Tortochot-Megne Fotso ... Andreas Frick
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    LRRK2 regulates synaptic function through modulation of actin cytoskeletal dynamics

    Giulia Tombesi, Shiva Kompella ... Elisa Greggio
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Neuroscience

    Visual Working Memory Guides Attention Rhythmically

    Jiachen Lu, Yaochun Cai, Xilin Zhang
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Incomplete
    1. Neuroscience

    The resource elasticity of control

    Levi Solomyak, Aviv Emanuel, Eran Eldar
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Solid
    • Incomplete
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Macroscopic Analyses of RNA-Seq Data to Reveal Chromatin Modifications in Aging and Disease

    Achal Mahajan, Francesca Ratti ... Vishrawas Gopalakrishnan
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
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