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    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    The Shigella flexneri effector IpaH1.4 facilitates RNF213 degradation and protects cytosolic bacteria against interferon-induced ubiquitylation

    Luz Saavedra-Sanchez, Mary S Dickinson ... Jorn Coers
    The enteric bacterial Shigella secretes a virulence factor that degrades the pivotal human defense protein RNF213, thereby protecting cytosolic bacteria from interferon-driven ubiquitylation and associated innate immunity.
    1. Neuroscience

    Center-surround inhibition in expectation and its underlying computational and artificial neural network models

    Ling Huang, Shiqi Shen ... Xilin Zhang
    Expectation optimizes perception through center-surround inhibition, enhancing expected representations while suppressing similar, irrelevant ones.
    1. Neuroscience

    Functional and molecular insights into muscle proprioceptors

    Francois Lallemend, Prach Techameena, Saida Hadjab
    The emerging taxonomy of proprioceptive neuron subtypes provides a framework for dissecting the cellular logic of sensorimotor control.
    1. Cancer Biology
    2. Cell Biology

    Human RAP2A homolog of the Drosophila asymmetric cell division regulator Rap2l targets the stemness of glioblastoma stem cells

    Maribel Franco, Ricardo Gargini ... Ana Carmena
    Restitution of RAP2A, human homolog of Drosophila asymmetric cell division regulator Rap2l, in glioblastoma neurosphere cultures targets the stemness of glioblastoma stem cells and could contribute to reduce glioblastoma expansion.
    1. Physics of Living Systems

    Revealing global stoichiometry conservation architecture in cells from Raman spectral patterns

    Ken-ichiro F Kamei, Koseki J Kobayashi-Kirschvink ... Yuichi Wakamoto
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Neuroscience

    Statistical learning of uniform- and mixed-length artificial languages: Different computational mechanisms support different task demands

    Meili Luo, Ran Cao, Felix Hao Wang
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Medicine
    2. Immunology and Inflammation

    Hyperactivated Glycolysis Drives Spatially-Patterned Kupffer Cell Depletion in MASLD

    Jia He, Ran Li ... Zhao Shan
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Cancer Biology

    Candida albicans drives colorectal cancer progression by inducing hypoxia signaling

    Wanqiu Wang, Mengqi Yang ... Kun Sun
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Neuroscience

    An interneuronal CRH and CRHBP circuit stabilizes birdsong performance

    Bradley M Colquitt, Michael S Brainard
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Neuroscience

    Prosapip1 (encoded by the Lzts3 gene) in the dorsal hippocampus mediates synaptic protein composition, long-term potentiation, and spatial memory

    Zachary W Hoisington, Himanshu Gangal ... Dorit Ron
    Novel function of Prosapip1, a scaffolding protein highly expressed in the hippocampus, in maintaining postsynaptic density integrity and plays a vital role in synaptic plasticity, learning, and memory.
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