Christopher J Gill, Christian E Gunning ... Pejman Rohani
Longitudinal qPCR-based pertussis surveillance of a low-resource African cohort reveals frequent asymptomatic pertussis infections in both young infants and mothers and suggests possible early warning signals for epidemic outbreaks.
Mihály Vöröslakos, Peter C Petersen ... György Buzsáki
A reusable system of 3D printed stainless steel microdrive and plastic head cap allows stable recording of electrophysiological data in mice and rats and easy recovery of silicon probes.
Persistent, non-random sensorimotor connectivity reveals the capacity of intrinsic spinal networks to purposefully replay and modify learned patterns of neural transmission during unconsciousness.
A new soma-targeted variant of the large-conductance blue-light-sensitive opsin CoChR combined with advanced optical stimulation methods allows high-efficiency all-optical neuronal imaging and stimulation in mouse brain in vivo.
Receptors for two distinct pathways are linked to choreograph the dynamic interaction of Wnt on the stem cell membrane, which leads to the control of asymmetric cell division.
Adam Filipowicz, Jonathan Lalsiamthara, Alejandro Aballay
Behavioral assays using Caenorhabditis elegans show that a learned pathogen avoidance following intestinal distention requires specific chemosensory neurons and TRPM channels in the intestine and excretory cell.
Sebastian Hückesfeld, Philipp Schlegel ... Michael J Pankratz
Core of a neuroendocrine synaptic network consists of a parallel set of interneurons that target distinct combinations of neuroendocrine outputs, thus enabling variability and flexibility in selection of physiological activity.
Dopaminergic medication has differential effects on the discovered electrophysiological networks, which could be used to develop new electrical and pharmacological interventions in Parkinson’s disease.
Timurs Maculins, Erik Verschueren ... Aditya Murthy
Multiplexed mass spectrometry shows how the autophagy gene Atg16l1 regulates macrophage innate immunity against intracellular bacterial pathogens by modulating basal oxidative stress responses.