Browse our latest research

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    1. Epidemiology and Global Health

    Asymptomatic Bordetella pertussis infections in a longitudinal cohort of young African infants and their mothers

    Christopher J Gill, Christian E Gunning ... Pejman Rohani
    Longitudinal qPCR-based pertussis surveillance of a low-resource African cohort reveals frequent asymptomatic pertussis infections in both young infants and mothers and suggests possible early warning signals for epidemic outbreaks.
    1. Neuroscience

    Metal microdrive and head cap system for silicon probe recovery in freely moving rodent

    Mihály Vöröslakos, Peter C Petersen ... György Buzsáki
    A reusable system of 3D printed stainless steel microdrive and plastic head cap allows stable recording of electrophysiological data in mice and rats and easy recovery of silicon probes.
    1. Neuroscience

    Spontaneous neural synchrony links intrinsic spinal sensory and motor networks during unconsciousness

    Jacob Graves McPherson, Maria F Bandres
    Persistent, non-random sensorimotor connectivity reveals the capacity of intrinsic spinal networks to purposefully replay and modify learned patterns of neural transmission during unconsciousness.
    1. Neuroscience

    Optogenetic strategies for high-efficiency all-optical interrogation using blue-light-sensitive opsins

    Angelo Forli, Matteo Pisoni ... Tommaso Fellin
    A new soma-targeted variant of the large-conductance blue-light-sensitive opsin CoChR combined with advanced optical stimulation methods allows high-efficiency all-optical neuronal imaging and stimulation in mouse brain in vivo.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Wnt- and glutamate-receptors orchestrate stem cell dynamics and asymmetric cell division

    Sergi Junyent, Joshua C Reeves ... Shukry J Habib
    Receptors for two distinct pathways are linked to choreograph the dynamic interaction of Wnt on the stem cell membrane, which leads to the control of asymmetric cell division.
    1. Microbiology and Infectious Disease
    2. Neuroscience

    TRPM channels mediate learned pathogen avoidance following intestinal distention

    Adam Filipowicz, Jonathan Lalsiamthara, Alejandro Aballay
    Behavioral assays using Caenorhabditis elegans show that a learned pathogen avoidance following intestinal distention requires specific chemosensory neurons and TRPM channels in the intestine and excretory cell.
    1. Neuroscience

    Unveiling the sensory and interneuronal pathways of the neuroendocrine connectome in Drosophila

    Sebastian Hückesfeld, Philipp Schlegel ... Michael J Pankratz
    Core of a neuroendocrine synaptic network consists of a parallel set of interneurons that target distinct combinations of neuroendocrine outputs, thus enabling variability and flexibility in selection of physiological activity.
    1. Neuroscience

    Differential dopaminergic modulation of spontaneous cortico–subthalamic activity in Parkinson’s disease

    Abhinav Sharma, Diego Vidaurre ... Esther Florin
    Dopaminergic medication has differential effects on the discovered electrophysiological networks, which could be used to develop new electrical and pharmacological interventions in Parkinson’s disease.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    The critical role of Hedgehog-responsive mesenchymal progenitors in meniscus development and injury repair

    Yulong Wei, Hao Sun ... Ling Qin
    Meniscal Gli1+ cells are mesenchymal progenitors that contribute to the development and injury repair of meniscus.
    1. Cell Biology
    2. Immunology and Inflammation

    Multiplexed proteomics of autophagy-deficient murine macrophages reveals enhanced antimicrobial immunity via the oxidative stress response

    Timurs Maculins, Erik Verschueren ... Aditya Murthy
    Multiplexed mass spectrometry shows how the autophagy gene Atg16l1 regulates macrophage innate immunity against intracellular bacterial pathogens by modulating basal oxidative stress responses.