During ingestion of antibody-coated targets, phagocytes probe and deform the target via Arp2/3-dependent protrusions and myosin-dependent constriction during cup closure.
Michael Jonathan Lehrke, Michael Jeremy Shapiro ... Virginia Smith Shapiro
In the absence of ABCB7, B cell development is halted at the pro-B cell stage and stimulated splenic B cells have impaired proliferation and reduced class switch recombination.
Lars Hubatsch, Louise M Jawerth ... Christoph A Weber
Dynamical properties of liquid condensates can be quantitatively assessed by combining phase separation theory and photobleaching, which opens new avenues to understand their physicochemical properties and functioning.
Didac Vidal-Pineiro, Yunpeng Wang ... Anders Fjell
Longitudinal neuroimaging models reveal that cross-sectional indices of brain age do not significantly relate to ongoing brain change, that is, brain aging, but to lifelong, stable variations in brain structure emerging in early life.
Diogo Paramos-de-Carvalho, Antonio Jacinto, Leonor Saúde
A time-gated model is proposed to reconcile the transient vs. persistent biological activities of cellular senescence, in which 'time' seems to be the main orchestrator of the beneficial vs. detrimental effects of the senescent programme.
The proposed techniques enable researchers to disentangle the statistical features of neural population responses, and rigorously quantify how these features carry information about stimuli and experimental variables.
Piezo1 activity within keratinocytes slows healing of wounded skin via dynamic channel enrichment at regions of the wound edge, causing localized retraction and thus hindering keratinocyte migration during wound healing.
Comprehensive mouse genetic analyses show, by having mTORC1 constitutively active, a RPC divides and exhausts mitotic capacity faster than neighboring RPCs, and thus produces retinal cells that degenerate with aging-related changes in the mature mouse retina.
