The non-selective Na+ leak channel (NALCN) and the transient receptor potential 3 channel (TRPC3) cooperate in driving pacemaking in substantia nigra dopaminergic neurons.
Precise hydrogen-bond stabilization of the neck linker docking onto the catalytic motor domain, is crucial for motor activity and intracellular functions of the bi-directional mitotic kinesin-5 Cin8.
Richard Gao, Ruud L van den Brink ... Bradley Voytek
Invasive electrophysiological recording measures neuronal transmembrane current timescales across human cortex, which lengthens from sensory to association regions, follows variations in ion channel expressions, and alters with behavior and aging.
Analyses of cell type-specific data show that the maternal alleles of genes related to establishing and breaking seed dormancy are suppressed by different combinations of epigenetic marks in the endosperm of Arabidopsis.
Sequential therapy with only β-lactam antibiotics achieves surprisingly high potency by exploiting both low rates of spontaneous resistance emergence and low rates of spontaneous cross-resistance among the drugs in sequence.
Anna Osnato, Stephanie Brown ... Peter J Rugg-Gunn
Identifying the pathways that support human naive-state pluripotent stem cells provides insights into the signalling-based regulation of human pluripotency and enables informed decisions to improve conditions for pluripotent cell culture.
Fabien Duveau, Petra Vande Zande ... Patricia J Wittkopp
Mapping mutations affecting gene expression within the yeast genome and within a gene regulatory network reveals properties of the raw material for regulatory variation.
Visual impairment caused by monocular deprivation early in life can be reversed rapidly at older ages by temporarily blocking all activity in the non-deprived eye.
