Browse our latest research

Page 852 of 1,838
    1. Structural Biology and Molecular Biophysics

    Sterically confined rearrangements of SARS-CoV-2 Spike protein control cell invasion

    Esteban Dodero-Rojas, Jose N Onuchic, Paul Charles Whitford
    SARS-CoV-2 entry mechanism through membrane fusion is regulated by the spike protein glycosylation state.
    1. Developmental Biology
    2. Evolutionary Biology

    Studying evolution of the primary body axis in vivo and in vitro

    Kerim Anlas, Vikas Trivedi
    The shared capacity of stem cells to recapitulate initial body plan formation in vitro without species-specific cues, suggests the existence of alternative, evolutionarily conserved developmental trajectories.
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Probing the effect of clustering on EphA2 receptor signaling efficiency by subcellular control of ligand-receptor mobility

    Zhongwen Chen, Dongmyung Oh ... Jay T Groves
    EphA2 receptor clustering enhances signaling transductions by increasing receptor phosphorylation and binding dwell time of downstream molecules in living cells.
    1. Microbiology and Infectious Disease

    Co-circulation of multiple influenza A reassortants in swine harboring genes from seasonal human and swine influenza viruses

    Pia Ryt-Hansen, Jesper Schak Krog ... Lars Erik Larsen
    The abundance and complex genetic diversity of swIAV were documented and the zoonotic potential evaluated.
    1. Cell Biology
    2. Physics of Living Systems

    Distinct roles of nonmuscle myosin II isoforms for establishing tension and elasticity during cell morphodynamics

    Kai Weißenbruch, Justin Grewe ... Martin Bastmeyer
    The mechanical response of adherent cells in structured environments is shown to be shaped by the intricate interplay between the three different isoforms of an essential molecular motor.
    1. Neuroscience

    Dual mechanisms of opioid-induced respiratory depression in the inspiratory rhythm-generating network

    Nathan A Baertsch, Nicholas E Bush ... Jan-Marino Ramirez
    Opioids cause hyperpolarization and pre-synaptic suppression among a subset of preBötzinger Complex neurons to impair respiratory rhythmogenesis.
    1. Cell Biology
    2. Developmental Biology

    The cAMP effector PKA mediates Moody GPCR signaling in Drosophila blood–brain barrier formation and maturation

    Xiaoling Li, Richard Fetter ... Ulrike Gaul
    A polarized Moody/protein kinase A pathway plays an unrecognized central role in controlling the enormous cell growth and blood–brain barrier integrity in a highly coordinated spatiotemporal manner in brain homeostasis.
    1. Biochemistry and Chemical Biology

    Disintegration promotes protospacer integration by the Cas1-Cas2 complex

    Chien-Hui Ma, Kamyab Javanmardi ... Makkuni Jayaram
    Disintegration, regarded as an abortive side reaction antithetical to DNA transposition, can promote protospacer integration at the CRISPR locus via DNA repair pathways.
    1. Physics of Living Systems

    Ciliary chemosensitivity is enhanced by cilium geometry and motility

    David Hickey, Andrej Vilfan, Ramin Golestanian
    Chemical receptors located on cilia can achieve particle capture rates that are many times higher than receptors located on a flat epithelial surface.
    1. Chromosomes and Gene Expression

    Rad53 checkpoint kinase regulation of DNA replication fork rate via Mrc1 phosphorylation

    Allison W McClure, John FX Diffley
    DNA replication fork rate in budding yeast is regulated in response to DNA damage by phosphorylation of two proteins, Mrc1 and Mcm10, by the Rad53 protein kinase.