The shared capacity of stem cells to recapitulate initial body plan formation in vitro without species-specific cues, suggests the existence of alternative, evolutionarily conserved developmental trajectories.
EphA2 receptor clustering enhances signaling transductions by increasing receptor phosphorylation and binding dwell time of downstream molecules in living cells.
Kai Weißenbruch, Justin Grewe ... Martin Bastmeyer
The mechanical response of adherent cells in structured environments is shown to be shaped by the intricate interplay between the three different isoforms of an essential molecular motor.
A polarized Moody/protein kinase A pathway plays an unrecognized central role in controlling the enormous cell growth and blood–brain barrier integrity in a highly coordinated spatiotemporal manner in brain homeostasis.
Disintegration, regarded as an abortive side reaction antithetical to DNA transposition, can promote protospacer integration at the CRISPR locus via DNA repair pathways.
DNA replication fork rate in budding yeast is regulated in response to DNA damage by phosphorylation of two proteins, Mrc1 and Mcm10, by the Rad53 protein kinase.