Browse our latest research

Page 939 of 1,751
    1. Neuroscience

    Rapid purification and metabolomic profiling of synaptic vesicles from mammalian brain

    Lynne Chantranupong, Jessica L Saulnier ... Bernardo L Sabatini
    Extensive mass spectrometry-based profiling of polar metabolites within synaptic vesicles that are rapidly isolated either from cultured mouse neurons or directly from mouse brains reveals their neurotransmitter composition.
    1. Neuroscience

    Optogenetic inhibition-mediated activity-dependent modification of CA1 pyramidal-interneuron connections during behavior

    Igor Gridchyn, Philipp Schoenenberger ... Jozsef Csicsvari
    The optogenetic manipulation of hippocampal neuronal circuit activity revealed plastic changes of pyramidal-interneuron connections in behaving animals, which were primarily governed by the firing rate change of postsynaptic interneurons.
    1. Developmental Biology

    Neuronal octopamine signaling regulates mating-induced germline stem cell increase in female Drosophila melanogaster

    Yuto Yoshinari, Tomotsune Ameku ... Ryusuke Niwa
    Genetic analyses using the fruit fly illustrate how neuronal system couples germline stem cell increase to an external cue, which is mating, through stem cell niche signaling.
    1. Cell Biology
    2. Neuroscience

    A feedback loop governs the relationship between lipid metabolism and longevity

    Nicole K Littlejohn, Nicolas Seban ... Supriya Srinivasan
    The dual control of adiposity and longevity emerges from a latent intestinal feedback loop which simultaneously augments fat loss and shields lifespan from the deleterious effects of continuous fat oxidation.
    1. Neuroscience

    Cannabinoids modulate associative cerebellar learning via alterations in behavioral state

    Catarina Albergaria, N Tatiana Silva ... Megan R Carey
    Cannabinoid receptors modulate cerebellar learning, not through direct effects on synaptic plasticity, but as a secondary consequence of their modulation of behavioral state.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Intestinal microbiology shapes population health impacts of diet and lifestyle risk exposures in Torres Strait Islander communities

    Fredrick M Mobegi, Lex EX Leong ... Geraint B Rogers
    Host-microbe interactions are an important influence on changing disease burdens in vulnerable remote communities.
    1. Cancer Biology

    Replication Study: Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs

    Hongyan Wang, Hanna S Radomska ... Reproducibility Project: Cancer Biology
    Editors' Summary: This Replication Study did not reproduce those experiments in the original paper that it attempted to reproduce.
    1. Neuroscience

    Optical control of ERK and AKT signaling promotes axon regeneration and functional recovery of PNS and CNS in Drosophila

    Qin Wang, Huaxun Fan ... Kai Zhang
    Precise spatiotemporal optogenetic activation of ERK and AKT signaling pathways reveals neural repair mechanisms of the peripheral and central nervous systems in live Drosophila larvae.
    1. Microbiology and Infectious Disease

    Unbiased homeologous recombination during pneumococcal transformation allows for multiple chromosomal integration events

    Jun Kurushima, Nathalie Campo ... Jan-Willem Veening
    DNA uptake and recombination in pneumococcus are highly efficient and independent of the cell-cycle or genetic location of the transformed allele, but limited to maximally 50% of the population.
    1. Developmental Biology

    Apelin signaling drives vascular endothelial cells toward a pro-angiogenic state

    Christian SM Helker, Jean Eberlein ... Didier YR Stainier
    Apelin signaling promotes sprouting behavior of endothelial cells by modulating their metabolic state.