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    1. Neuroscience

    Obesity causes selective and long-lasting desensitization of AgRP neurons to dietary fat

    Lisa R Beutler, Timothy V Corpuz ... Zachary A Knight
    Neurons that promote hunger become desensitized to dietary fat in obesity.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Antagonistic control of DDK binding to licensed replication origins by Mcm2 and Rad53

    Syafiq Abd Wahab, Dirk Remus
    The mechanism of Dbf4-dependent kinase (DDK) recruitment to replication origins and its regulation by the checkpoint have been identified.
    1. Microbiology and Infectious Disease

    Host sirtuin 2 as an immunotherapeutic target against tuberculosis

    Ashima Bhaskar, Santosh Kumar ... Vinay Kumar Nandicoori
    The inhibition of host Sirtuin-2 by AGK2 restricts mycobacterial growth in vivo by modulation of host transcriptome leading to activation of protective immune responses.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Chronic ethanol consumption compromises neutrophil function in acute pulmonary Aspergillus fumigatus infection

    Nathalia Luisa Sousa de Oliveira Malacco, Jessica Amanda Marques Souza ... Frederico Marianetti Soriani
    Cell biology analysis demonstrated for the first time the effect of chronic ethanol consumption in neutrophil impaired migration by CXCR2 downregulation and neutrophil function during acute Aspergillus fumigatus infection.
    1. Neuroscience

    Boosts in brain signal variability track liberal shifts in decision bias

    Niels A Kloosterman, Julian Q Kosciessa ... Douglas D Garrett
    Modulation of moment-to-moment irregularity of neural activity closely tracks our ability to flexibly adapt decision biases to the environment.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    Gene autoregulation by 3’ UTR-derived bacterial small RNAs

    Mona Hoyos, Michaela Huber ... Kai Papenfort
    Bacterial small RNAs derived from the 3' untranslated region of an mRNA can serve as autoregulatory elements.
    1. Developmental Biology
    2. Physics of Living Systems

    Cell lineage-dependent chiral actomyosin flows drive cellular rearrangements in early Caenorhabditis elegans development

    Lokesh G Pimpale, Teije C Middelkoop ... Stephan W Grill
    Developmentally controlled chiral counter-rotating actomyosin flows drive cell-lineage spindle skews and cell rearrangements during cytokinesis in early nematode development.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Electron tomography visualization of HIV-1 fusion with target cells using fusion inhibitors to trap the pre-hairpin intermediate

    Mark S Ladinsky, Priyanthi NP Gnanapragasam ... Pamela J Bjorkman
    Visualization of HIV-1 fusion by trapping the prehairpin intermediate.
    1. Cell Biology
    2. Neuroscience

    Microtubules originate asymmetrically at the somatic golgi and are guided via Kinesin2 to maintain polarity within neurons

    Amrita Mukherjee, Paul S Brooks ... Paul T Conduit
    The somatic Golgi acts as an asymmetric MTOC within Drosophila neurons, and this, together with the action Kinesin-2, helps maintain minus-end-out microtubule polarity with proximal dendrites.
    1. Cell Biology
    2. Developmental Biology

    Regulation of BMP4/Dpp retrotranslocation and signaling by deglycosylation

    Antonio Galeone, Joshua M Adams ... Hamed Jafar-Nejad
    The cytoplasmic enzyme N-glycanase 1 plays an evolutionary conserved role in promoting the ERAD-mediated retrotranslocation of misfolded Dpp/BMP4 from the ER, thereby allowing BMP signaling in specific contexts.