March 2013

Research articles

    1. Plant Biology
    2. Developmental Biology and Stem Cells

    Sugar is an endogenous cue for juvenile-to-adult phase transition in plants

    Sha Yu et al.
    Sugar levels in leaves act as a signal for plants to switch from their juvenile to their adult form by regulating the expression of two genes.
    1. Developmental Biology and Stem Cells
    2. Plant Biology

    Sugar promotes vegetative phase change in Arabidopsis thaliana by repressing the expression of MIR156A and MIR156C

    Li Yang et al.
    Sugar levels in leaves act as a signal for plants to switch from their juvenile to their adult form by regulating the expression of two genes.
    1. Neuroscience

    Selection of distinct populations of dentate granule cells in response to inputs as a mechanism for pattern separation in mice

    Wei Deng et al.
    By using different groups of cells to represent distinct environments and events, the dentate gyrus of the hippocampus helps to keep memories of similar events separate.
    1. Developmental Biology and Stem Cells
    2. Neuroscience

    LIN-12/Notch signaling instructs postsynaptic muscle arm development by regulating UNC-40/DCC and MADD-2 in Caenorhabditis elegans

    Pengpeng Li et al.
    The Notch signaling pathway has a central role in the formation of the circuit that controls egg-laying in the nematode worm C. elegans.
    1. Developmental Biology and Stem Cells
    2. Neuroscience

    Sox10-dependent neural crest origin of olfactory microvillous neurons in zebrafish

    Ankur Saxena et al.
    Sensory neurons in the olfactory system develop from two different regions of the ectoderm, the olfactory placode and the cranial neural crest, whereas sensory neurons within the eye and ear develop from just one region.
    1. Genes and Chromosomes
    2. Plant Biology

    Plants regenerated from tissue culture contain stable epigenome changes in rice

    Hume Stroud et al.
    The use of tissue culture reduces the chemical modification of plant DNA, and this has lasting effects on gene expression in the plants and their descendants.
    1. Neuroscience

    Kinesin-1 regulates dendrite microtubule polarity in Caenorhabditis elegans

    Jing Yan et al.
    A cellular motor protein helps to ensure that microtubules are oriented correctly within neuronal dendrites
    1. Developmental Biology and Stem Cells
    2. Neuroscience

    Mutual inhibition among postmitotic neurons regulates robustness of brain wiring in Drosophila

    Marion Langen et al.
    The Notch signaling pathway has a central role in the development of the nervous system, and also in the establishment of networks of connections in the adult brain
    1. Biophysics and Structural Biology

    De novo modeling of the F420-reducing [NiFe]-hydrogenase from a methanogenic archaeon by cryo-electron microscopy

    Deryck J Mills et al.
    The structure of a large hydrogenase complex involved in the production of methane by microbes has been determined with cryo-electron microscopy.
    1. Cell Biology
    2. Neuroscience

    AP2 hemicomplexes contribute independently to synaptic vesicle endocytosis

    Mingyu Gu et al.
    A protein complex that enables cells to transport substances across their membranes, and that typically consists of four subunits, can also function as two hemicomplexes, each with two subunits.
    1. Biophysics and Structural Biology
    2. Genes and Chromosomes

    The AFF4 scaffold binds human P-TEFb adjacent to HIV Tat

    Ursula Schulze-Gahmen et al.
    Structure-function analysis of the super elongation complex formed when HIV replicates inside cells reveals that the HIV-1 Tat protein binds to a cleft between P-TEFb, an enzyme that is involved in normal transcription, and AFF4, a protein that is used to build the super elongation complex