Browse our Research Advances

Page 36 of 51
    1. Neuroscience

    The relationship between spatial configuration and functional connectivity of brain regions revisited

    Janine Diane Bijsterbosch, Christian F Beckmann ... Samuel J Harrison
    The estimation of functional connectivity network matrices from resting state fMRI is driven by a combination of spatial and temporal factors in the presence of spatially overlapping network structure.
    1. Cell Biology

    Generation of endogenous pH-sensitive EGF receptor and its application in high-throughput screening for proteins involved in clathrin-mediated endocytosis

    Mads Breum Larsen, Mireia Perez Verdaguer ... Alexander Sorkin
    CRISPR/Cas9 gene-editing was used to generate a novel endogenous pH-sensitive EGF receptor chimera with the unique utility to study receptor endocytosis in a single-cell and high-throughput experimental formats.
    1. Epidemiology and Global Health

    Impact of seasonal variations in Plasmodium falciparum malaria transmission on the surveillance of pfhrp2 gene deletions

    Oliver John Watson, Robert Verity ... Hannah C Slater
    The timing of surveillance for pfhrp2/3-deletions within a transmission season impacts estimates of the proportion of false-negative RDTs due to deletions, which may cause premature decisions to change RDT.
    1. Neuroscience

    Sustained NPY signaling enables AgRP neurons to drive feeding

    Yiming Chen, Rachel A Essner ... Zachary A Knight
    A specific neuropeptide is responsible for the ability of AgRP neurons to generate long-lasting hunger.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Mechanics and dynamics of translocating MreB filaments on curved membranes

    Felix Wong, Ethan C Garner, Ariel Amir
    Principal curvature-dependent motion of bacterial actin MreB results in localization consistent with all known literature.
    1. Microbiology and Infectious Disease

    Francisella tularensis enters a double membraned compartment following cell-cell transfer

    Shaun P Steele, Zach Chamberlain ... Thomas H Kawula
    Francisella tularensis spreads from cell to cell when macrophages engulf small portions of infected cells upon cell contact, forming distinctive a double membraned endosome containing multiple bacteria per individual vacuole.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Myonuclear accretion is a determinant of exercise-induced remodeling in skeletal muscle

    Qingnian Goh, Taejeong Song ... Douglas P Millay
    Fusion of muscle progenitors drives continuous myonuclear accretion during exercise and impacts various adaptations in skeletal muscle including response to injury and hypertrophy.
    1. Neuroscience

    A thalamocortical circuit for updating action-outcome associations

    Virginie Fresno, Shauna L Parkes ... Mathieu Wolff
    Disconnection of the orbitofrontal cortex from the submedius nucleus but not the mediodorsal thalamus prevented rats to respond adaptively following action-outcome reversal, showing differential involvement of these thalamocortical circuits.
    1. Cell Biology
    2. Computational and Systems Biology

    Saccharomyces cerevisiae goes through distinct metabolic phases during its replicative lifespan

    Simeon Leupold, Georg Hubmann ... Matthias Heinemann
    With replicative age, S. cerevisiae shifts from a fermentative towards an unusual respiratory metabolism, accompanied by a decrease in growth and glucose uptake rate.
    1. Cell Biology
    2. Genetics and Genomics

    Endoplasmic reticulum-associated SKN-1A/Nrf1 mediates a cytoplasmic unfolded protein response and promotes longevity

    Nicolas J Lehrbach, Gary Ruvkun
    SKN-1A/Nrf1 promotes healthy aging by activating protein degradation in response to accumulation of misfolded proteins.