Browse our Research Advances

Building on previous work (Mysling et al., 2016), it is shown that angiopoietin-like protein 4 (ANGPTL4) inhibits lipoprotein lipase activity by catalyzing the unfolding of its hydrolase domain.

The iron/sphingolipid/PDK1/Mef2 pathway is activated in mammals upon loss of Frataxin.

Integrated modeling of sgRNA positioning, chromatin accessibility, and sequence features enables accurate prediction of effective target sites for CRISPR-mediated transcriptional modulation and design of highly active libraries for genome-scale genetic screens.

Building on previous work (Uervirojnangkoorn et al., 2015), we demonstrate how improved methods for processing XFEL diffraction data enable the determination of structures from poorly diffracting crystals.

Building on previous work (Pless, 2013), we argue that side-chain 'flip out' is a key event in potassium channel C-type inactivation, and propose a new method for encoding multiple noncanonical amino acids and controlling protein stoichiometry.

Building on previous work (Dye et al., 2015) showing that pluripotent stem cell derived lung organoids were immature/fetal, the current study shows that in vivo transplantation leads to mature tissue, reminiscent of adult airways.

Variability in individual neurons' temporal receptive fields of integration is found to explain the heterogeneity of neuronal responses observed in prefrontal cortex during reward-guided decision making.

Building on previous work (Guarani et al., 2015), MICOS (mitochondrial contact site) assembly and cristae junction formation are shown to have a critical role in human health.

Building on previous work (Booth et al, 2014), we show how two mitotic phosphatases are formed, how they are regulated by opposing kinases during the cell cycle and reveal a novel opportunity for the development of cancer therapeutics.

Building on previous work (Aso et al., 2014a; Aso et al., 2014b), cell-type-specific drivers and optogenetics are used to control the local release of dopamine and reveal that distinct learning rules are implemented in parallel memory units.