Browse our Research Advances

Quantitative analysis of cell dynamics over a range of timescales reveals that core PCP is not required to organize large-scale tissue flows but does affect short timescale mechanics.

Improved cell-type-specific genetic drivers for the study of learning and memory and other complex behaviors in Drosophila are provided and validated.

An enhanced bioinformatic pipeline to quantify Plasmodium falciparum core gene and polymorphic var gene expression revealed changes occurring during early culture adaptation of parasites from naturally infected individuals.

Numerous pathways/function predictions were identified via gene sets, phosphopeptides, and phosphoproteins, which may point to potential novel therapeutic targets to enhance heart adaptivity, maintaining heart performance while avoiding cardiac dysfunction.

Microbial macroecological patterns under coarse-graining are captured by a null model of ecology, a result which was leveraged to successfully predict the relationship between fine and coarse-grained diversity.

Silencing long-descending propriospinal neurons that connect C6 to L2 disrupts right-left alternation of both the forelimbs and hindlimbs in the intact animal, but leads to improved stepping after a mild-moderate thoracic contusion spinal cord injury.

In vitro and in vivo studies uncovered a molecular link between elevated mitochondrial ceramide levels, coenzyme Q depletion, and insulin resistance.

Activating mutations in the leucine-rich repeat kinase 2 cause Parkinson’s disease, and an unbiased genome-wide screen revealed an unexpected, specific role for Rab12 in activating this kinase directly for Rab GTPase phosphorylation.

2D template matching enables a streamlined single-particle cryogenic electron microscopy workflow that can be used to discover new high-resolution structural features in molecules and complexes, such as bound ligands and drugs.

Open science and consensus antibody validation protocols can identify high-quality, renewable antibodies for the ~50% of the human proteome currently covered, enabling robust and reproducible biomedical research.