Browse our Research Articles

Page 124 of 1,404
    1. Developmental Biology
    2. Neuroscience

    Adverse impact of female reproductive signaling on age-dependent neurodegeneration after mild head trauma in Drosophila

    Changtian Ye, Ryan Ho ... James Q Zheng
    A head concussion model in fruit flies reveals that early-life exposure to mild concussions significantly increases the risk of late-life neurodegeneration, with females especially vulnerable due to reproductive factors.
    1. Immunology and Inflammation

    Defining cell type-specific immune responses in a mouse model of allergic contact dermatitis by single-cell transcriptomics

    Youxi Liu, Meimei Yin ... Ling-juan Zhang
    Dermal preadipocytes produce T cell chemokines in response to IFNγ, driving the recruitment and activation of type 1 effector T cells in allergic contact dermatitis.
    1. Cancer Biology

    Inhibition of ULK1/2 and KRASG12C controls tumor growth in preclinical models of lung cancer

    Phaedra C Ghazi, Kayla T O'Toole ... Martin McMahon
    Inhibiting KRASG12C and ULK-mediated autophagy is a novel treatment strategy to control the growth of KRASG12C-driven lung cancer in preclinical models of lung cancer.
    1. Neuroscience

    Quantitative modeling of the emergence of macroscopic grid-like representations

    Ikhwan Bin Khalid, Eric T Reifenstein ... Richard Kempter
    A computational study quantifies how macroscopic grid-like representations may emerge in the human brain using different hypotheses and navigation patterns, indicating the need to further characterize properties of grid cells.
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    MDverse, shedding light on the dark matter of molecular dynamics simulations

    Johanna KS Tiemann, Magdalena Szczuka ... Pierre Poulain
    Identifying, indexing, and annotating molecular dynamics simulations open data is essential to ensure their proper reuse.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Long-distance electron transport in multicellular freshwater cable bacteria

    Tingting Yang, Marko S Chavez ... Mohamed Y El-Naggar
    A biophysical approach sheds light on the electron transport physics and electric metabolism of centimeter-long filamentous freshwater cable bacteria.
    1. Cell Biology

    Damage-induced basal epithelial cell migration modulates the spatial organization of redox signaling and sensory neuron regeneration

    Alexandra M Fister, Adam Horn ... Anna Huttenlocher
    Isotonic treatment limits keratinocyte movement, spatially restricts reactive oxygen species production, and rescues sensory neuron function after thermal injury.
    1. Microbiology and Infectious Disease

    Polysaccharides induce deep-sea Lentisphaerae strains to release chronic bacteriophages

    Chong Wang, Rikuan Zheng ... Chaomin Sun
    Chronic bacteriophages are induced by the supplement of polysaccharide in the deep-sea Lentisphaerae strains, and these bacteriophages potentially reprogram host polysaccharide metabolism through the auxiliary metabolic genes.
    1. Microbiology and Infectious Disease

    Divergent downstream biosynthetic pathways are supported by L-cysteine synthases of Mycobacterium tuberculosis

    Mehak Zahoor Khan, Debbie M Hunt ... Vinay Kumar Nandicoori
    CysM and CysK2 play complementary and overlapping roles in Mtb's adaptation to environmental stress that are crucial for survival.
    1. Medicine

    PKR activation-induced mitochondrial dysfunction in HIV-transgenic mice with nephropathy

    Teruhiko Yoshida, Khun Zaw Latt ... Jeffrey B Kopp
    Single-nuclear transcriptomic profiling and functional assays identified PKR activation and mitochondrial dysfunction in HIV-associated nephropathy mice kidneys.