A head concussion model in fruit flies reveals that early-life exposure to mild concussions significantly increases the risk of late-life neurodegeneration, with females especially vulnerable due to reproductive factors.
Dermal preadipocytes produce T cell chemokines in response to IFNγ, driving the recruitment and activation of type 1 effector T cells in allergic contact dermatitis.
Phaedra C Ghazi, Kayla T O'Toole ... Martin McMahon
Inhibiting KRASG12C and ULK-mediated autophagy is a novel treatment strategy to control the growth of KRASG12C-driven lung cancer in preclinical models of lung cancer.
Ikhwan Bin Khalid, Eric T Reifenstein ... Richard Kempter
A computational study quantifies how macroscopic grid-like representations may emerge in the human brain using different hypotheses and navigation patterns, indicating the need to further characterize properties of grid cells.
Alexandra M Fister, Adam Horn ... Anna Huttenlocher
Isotonic treatment limits keratinocyte movement, spatially restricts reactive oxygen species production, and rescues sensory neuron function after thermal injury.
Chronic bacteriophages are induced by the supplement of polysaccharide in the deep-sea Lentisphaerae strains, and these bacteriophages potentially reprogram host polysaccharide metabolism through the auxiliary metabolic genes.
Teruhiko Yoshida, Khun Zaw Latt ... Jeffrey B Kopp
Single-nuclear transcriptomic profiling and functional assays identified PKR activation and mitochondrial dysfunction in HIV-associated nephropathy mice kidneys.