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Protein, but not mRNA, levels of neurodegenerative disease-associated protein TDP-43 are decreased upon knockdown of BORC, a complex that is required for the anterograde transport of lysosomes.

Firing rate analyses revealed neurons throughout the hippocampus, amygdala, orbitofrontal cortex, and anterior cingulate cortex in humans that exhibited heterogeneous responses to intracranial theta burst stimulation of the human brain.

A combination of cell biological, biochemical, and computational approaches characterizes the conserved membrane-targeting sequence of bactofilins and reveals a mutual influence of membrane binding and bactofilin polymerization.

Ancyromonad channelrhodopsins advance understanding of ionic selectivity and wavelength regulation in light-gated ion channels, and expand the toolkit for multiplexing with red-shifted fluorescent sensors.

Analysis of phenotype and molecular pathogenesis in a new LAMA2-related muscular dystrophy mouse model.

A neutrality index identifies mox-YG as a minimally cytotoxic protein, enabling ultra-high expression and uncovering key physiological consequences of protein burden.

Sex-biased gene expression in the body organs evolves rapidly, supporting a mosaic model of maleness and femaleness across tissues and thus challenging binary views of sex characteristics in mammals.

Lipid binding stabilizes the SARS-CoV-2 Orf9b homodimer, slowing its conversion to the Tom70-binding monomeric form and modulating interferon suppression.

HPV cfDNA is a highly effective tumor marker for monitoring disease progression and treatment response in HPV-positive cervical cancer, offering valuable insights for guiding clinical decisions in precision medicine.

KIF7 loss of function affects several developmental stages of the cerebral cortex and likely causes neurodevelopmental delay, intellectual disability, and epilepsia observed in ciliopathic patients with KIF7 mutations.