Abdulkadir Ozkan, Hari K Padmanabhan ... Jeffrey D Macklis
Developmentally-based directed differentiation from cortical progenitors sets a foundation for in vitro mechanistic and therapeutic disease modeling, and toward regenerative neuronal repopulation and circuit repair.
A microglia replacement approach demonstrates that brain macrophages with patient mutations from Aicardi–Goutières syndrome, a genetic, brain predominant interferonopathy, are sufficient to drive interferon responses.
Durafshan Sakeena Syed, Primoz Ravbar, Julie H Simpson
Anatomical and behavioral characterization of inhibitory neurons in the Drosophila ventral nerve cord shows their critical, diverse roles in limb coordination.
Bidirectional modulation of the activity of the synaptic protein mGluR5 alters spontaneous mouse motor behavior and produces correlated changes in co-activity patterns among direct pathway neurons in the dorsal striatum.
Developmental electrophysiological adaptations and heat-sensitive proteins, such as TRPV3, in cortical excitatory neurons help maintain stable activity levels when brain temperature rises by 2–3°C during fever.
Upregulation of the β subunit of translation initiation factor eIF2 underlies autophagy suppression and premature aging caused by disruption of axonal transport of mitochondria.
Deep behavioral phenotyping reveals that performance readouts from single-valence conditioning are biased by baseline sex differences in exploration, and mixed-valence conditioning provides a clearer assessment of learning in both sexes.
A computational model of the striatal dopamine system predicts transporter expression and organisation as key determinants of regional striatal dopamine dynamics and distinct signal decoding by D1 and D2 receptors.
Pien Margien van Paassen, Alexander O Pasternak ... Godelieve J de Bree
In individuals who started antiretroviral therapy during acute HIV infection, the proliferative capacity of HIV-specific CD8+ T-cells at 24 weeks of therapy predicted the subsequent reduction in the viral reservoir.
In a randomized trial, ART intensification by doubling the dolutegravir dosage in people with HIV stably suppressed on dolutegravir-based ART reduced levels of four HIV reservoir markers in peripheral blood.
